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| 1 | Viral hepatitis update: Progress and perspectives显示文摘Viral hepatitis,secondary to infection with hepatitis A,B,C,D,and E viruses,are a major public health problem and an important cause of morbidity and mortality.Despite the huge medical advances achieved in recent years,there are still points of conflict concerning the pathogenesis,immune response,development of new and more effective vaccines,therapies,and treatment.This review focuses on the most important research topics that deal with issues that are currently being solved,those that remain to be solved,and future research directions.For hepatitis A virus we will address epidemiology,molecular surveillance,new susceptible populations as well as environmental and food detections.In the case of hepatitis B virus,we will discuss host factors related to disease,diagnosis,therapy,and vaccine improvement.On hepatitis C virus,we will focus on pathogenesis,immune response,direct action antivirals treatment in the context of solid organ transplantation,issues related to hepatocellular carcinoma development,direct action antivirals resistance due to selection of resistanceassociated variants,and vaccination.Regarding hepatitis D virus,we describe diagnostic methodology,pathogenesis,and therapy.Finally,for hepatitis E virus,we will address epidemiology(including new emerging species),diagnosis,clinical aspects,treatment,the development of a vaccine,and environmental surveillance. | María B Pisano Cecilia G Giadans Diego M Flichman Viviana E Ré María V Preciado Pamela Valva | 2021 | World Journal of Gastroenterology2021，27，26： | 8 |
| 2 | Hepatitis C virus molecular evolution:Transmission,disease progression and antiviral therapy显示文摘Hepatitis C virus(HCV)infection represents an important public health problem worldwide.Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors.Virus molecular evolution plays an important role in HCV transmission,disease progression and therapy outcome.The high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures(e.g.,host immune responses and antiviral therapy).HCV molecular evolution is shaped by different mechanisms including a high mutation rate,genetic bottlenecks,genetic drift,recombination,temporal variations and compartmentalization.These evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging manner.Remarkable advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against HCV.As a result,superior sustained viral responses have been attained.The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer,more potent antivirals,bringing us one step closer to the interferon-free era. | Maria Victoria Preciado Pamela Valva Alejandro Escobar-Gutierrez Paula Rahal Karina Ruiz-Tovar Lilian Yamasaki Carlos Vazquez-Chacon Armando Martinez-Guarneros Juan Carlos Carpio-Pedroza Salvador Fonseca-Coronado Mayra Cruz-Rivera | 2014 | World Journal of Gastroenterology2014，20，43： | 6 |
| 3 | Chronic hepatitis C virus infection:Serum biomarkers inpredicting liver damage显示文摘Currently, a major clinical challenge in the management of the increasing number of hepatitis C virus(HCV) infected patients is determining the best means for evaluating liver impairment. Prognosis and treatment of chronic hepatitis C(CHC) are partly dependent on the assessment of histological activity, namely cell necrosis and inflammation, and the degree of liver fibrosis. These parameters can be provided by liver biopsy; however, in addition to the risks related to an invasive procedure, liver biopsy has been associated with sampling error mostly due to suboptimal biopsy size. To avoid these pitfalls, several markers have been proposed as non-invasive alternatives for the diagnosis of liver damage. Distinct approaches among the currently available non-invasive methods are(1) the physical ones based on imaging techniques; and(2) the biological ones based on serum biomarkers. In this review, we discuss these approaches with special focus on currently available non-invasive serum markers. We will discuss:(1) class?Ⅰ?serum biomarkers individually and as combined panels, particularly those that mirror the metabolism of liver extracellular matrix turnover and/or fibrogenic cell changes;(2) class Ⅱ biomarkers that are indirect serum markers and are based on the evaluation of common functional alterations in the liver; and(3) biomarkers of liver cell death, since hepatocyte apoptosis plays a significant role in the pathogenesis of HCV infection. We highlight in this review the evidence behind the use of these markers and assess the diagnostic accuracy as well as advantages, limitations, and application in clinical practice of each test for predicting liver damage in CHC. | Pamela Valva Daniela A Ríos Elena De Matteo Maria V Preciado | 2016 | World Journal of Gastroenterology2016，22，4： | 2 |
| 4 | Apoptosis markers related to pathogenesis of pediatric chronic hepatitis C virus infection: M30 mirrors the severity of steatosis显示文摘 | Valva P De Matteo E Galoppo MC | 2010 | J Medi Virol2010，82，6： | 1 |
| 5 | Structural variability of the carboxy-terminus of Epstein-Barr virus encoded latent membrane protein 1 gene in Hodgkin's lymphomas显示文摘 | Guiretti DM Chabay PA Valva P | 2007 | J Med Virol2007，79，11： | 1 |
| 6 | Bone regeneration in cranio- plasty and clinical complications in rabbits with alloxan -induced diabetes 显示文摘 | Vieira EM Ueno CS Valva VN | 2008 | Braz Oral Res2008，22，： | 1 |
| 7 | Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes显示文摘 | Vieira EM Ueno CS Valva VN | 2008 | Braz Oral Res2008，22，2： | 1 |
| 8 | Structural variability of the carboxy-ter minus of Epstein-Barr virus encoded latent membrane protein I gene in Hodgkin' s lymphomas 显示文摘 | Guiretti DM Chabay PA Valva P | 2007 | J Med Virol2007，79，11： | 1 |
| 9 | Apoptosis markers related to pathogenesis of pediatric chronic hepatitis C virus infection:M30 mirrors the severity of steatosis显示文摘 | Valva P De Matteo E Galoppo MC | | 0，，06： | 1 |
| 10 | Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children显示文摘 | María Inés Gismondi Juan María Díaz Carrasco Pamela Valva Pablo Daniel Becker Carlos Alberto Guzmán Rodolfo Héctor Campos María Victoria Preciado | 2013 | Virology (-)2013，，1： | 1 |
| 11 | 李宇春,你还我的棒棒糖!显示文摘话说李宇春(昵称'葱')前往成都巡演的前一天,某位'大人物'漫不经心地告诉我一句话:'明天带你去后台见见你的偶像吧。'这句话对我产生了非常大的影响——当天夜里,我匆忙地去弄了个发型,然后上网告诉所有'玉米'们这个消息,等我从狂喜中稍微冷静下来时已经凌晨3点了。谁知天有不测风云,早上醒来时接到'大人物'的电话。 | Valvae | 2008 | 流行歌曲2008，0，2： | 0 |
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