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| 1 | Detection of expiratory flow limitation during exercise in COPD patients显示文摘 | Koulouris NG Dimopoulou I Valta P | 1997 | J Appl Physiol1997，82，3： | 1 |
| 2 | Activation of lum- bar paraspinal and abdominal muscles during therapeutic exerci- ses in chronic low back pain patients 显示文摘 | Arokoski JP Valta T Kankaanpaa M | 2004 | Arch Phys Med Reha- bil2004，85，5： | 1 |
| 3 | Clonidine provides opioid-sparing effect,stable hemodynamics,and renal integrity during laparoscopic cholecystectomy显示文摘 | Laisalmi M Koivusalo AM Valta P | 2001 | Surg Endosc2001，15，11： | 1 |
| 4 | Acute Respiratory Distress Syndrome: Frequency, Clinical Course, and Costs of Care显示文摘 | Valta P Uusaro A Nunes S | 1999 | Crit Care Med1999，27，23： | 1 |
| 5 | Detection of expiratory flow limitation during exercise in COPD patients显示文摘 | Koulouris NG Dimopoulou I Valta P | 1997 | J Appl Physiol1997，82，3： | 1 |
| 6 | Regulation of osteoblast differentiation:a novel function for fibroblast growth factor 8显示文摘 | Valta MP Hentunen T Qu Q | 2006 | Endocrinology2006，147，5： | 1 |
| 7 | Regulation of osteoblast differentiation: a novel function for fibroblast growth factor-8显示文摘 | Valta MP Henmnen T Qu Q ValveEM Harjula A Seppa' non JA | 2006 | Endocrinology2006，147，： | 1 |
| 8 | Activation of lum- bar paraspinal and abdominal muscles during therapeutic exer- cises in chronic low back pain patients 显示文摘 | Arokoski JP Valta T Kankaanpaa M | 2004 | Arch Phys Med Re- habil2004，85，5： | 1 |
| 9 | Back and abdominal muscle function during stabilization exercises显示文摘 | Arokoski J P Valta T Airaksinen O | 2001 | Areh Phys Med Rehabil2001，，82： | 1 |
| 10 | Prolonged attentional dwell time in dyslexic adults显示文摘 | Valta H Uutela K | | 0，，03： | 1 |
| 11 | The effects of ventilatory mode on lung aeration assessed with computer tomography: a ran- domized controlled study 显示文摘 | Varpula T Valta P Markkola A | 2009 | Intensive Care Med2009，24，2： | 1 |
| 12 | 急性呼吸窘迫综合征:发病率,临床过程,治疗费用显示文摘 | Valta,P 徐腾达 | 2000 | 世界医学杂志2000，4，8： | 1 |
| 13 | Importance of microenvironment in preclinical models of breast and prostate cancer显示文摘The majority of cancer drugs entering clinical trials fail to reach the market due to poor efficacy. Preclinicalefficacy has been traditionally tested using subcutaneous xenograft models that are cheap, fast and easy to perform. However, these models lack the correct tumor microenvironment, leading to poor clinical predictivity. Selecting compounds for clinical trials based on efficacy results obtained from subcutaneous xenograft models may therefore be one important reason for the high failure rates. In this review we concentrate in describing the role and importance of the tumor microenvironment in progression of breast and prostate cancer, and describe some breast and prostate cancer cell lines that are widely used in preclinical studies. We go through different preclinical efficacy models that incorporate the tissue microenvironment and should therefore be clinically more predictive than subcutaneous xenografts. These include three-dimensional cell culture models, orthotopic and metastasis models, humanized and transgenic mouse models, and patient-derived xenografts. Different endpoint measurements and applicable imaging techniques are also discussed. We conclude that models that incorporate the tissue microenvironment should be increasingly used in preclinical efficacy studies to reduce the current high attrition rates of cancer drugs in clinical trials. | Maija Valta Katja Fagerlund Mari Suominen Jussi Halleen Johanna Tuomela | 2015 | World Journal of Pharmacology2015，4，1： | 1 |
| 14 | Activation of lumbar paraspinal and abdominal muscles during therapeutic exercises in chronic low back pain patients显示文摘 | Arokoski JP Valta T Kankaanp(aa) M | 2004 | Arch Phys Med Rehabil2004，85，5： | 1 |
| 15 | 查看详情显示文摘 | Valta T Puputti E M Hyppnen I | | 0，，： | 1 |
| 16 | Impaired Bone Health in Inflammatory Bowel Disease: A Case–Control Study in 80 Pediatric Patients显示文摘 | Saila Laakso Helena Valta Matti Verkasalo Sanna Toiviainen-Salo Heli Viljakainen Outi M?kitie | 2012 | Calcified Tissue International2012，，2： | 1 |
| 17 | Regulation of osteoblast differentiation:a novel function for fibroblast growth factor 8显示文摘 | VALTA M P HENTUNEN T QU Qiang | 2006 | Endocrinology2006，147，5： | 1 |
| 18 | Impaired bone health in inflammatory bowel disease: a case-control study in 80 pediatric patients显示文摘 | Laakso S Valta H Verkasalo M | 2012 | Caleif Tissue Int2012，91，2： | 1 |
| 19 | Acute respiratory distress syndrome:frequency,clinical course,and costs of care显示文摘 | Valta P Uusaro A Nunes S | 1999 | Crit Care Med1999，27，11： | 1 |
| 20 | A simple method to detect expiratory flow limitation during spontaneous breathing显示文摘 | Valta P Lavoie A | 1995 | Eur Respir J1995，8，2： | 1 |
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