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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | Involvement of cell motility in tumor progreasion显示文摘 | Boyer B Valles AM Tucker GC | 1993 | Symp Soc Exp Biol1993，47，： | 2 |
| 3 | Efficient production of androgenic doubled-haploid mutants in barley by the application of sodium azide to anther and micrespore culture显示文摘 | Castillo AM Cistue L Valles MP | 2001 | Plant Cell Rep2001，20，： | 1 |
| 4 | Long-term treadmill exercise induces neuroprotective molecular changes in rat brain 显示文摘 | Bayod S del Valle J Canudas AM | 2011 | JAppl Physiol2011，111，5： | 1 |
| 5 | Comparison between Valdivia position and prone position in percutaneous nephrolithotomy显示文摘 | Amón Sesmero JH Del Valle González N Conde Redondo C | 2008 | Actas Urol Esp2008，32，4： | 1 |
| 6 | Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae显示文摘 | Chassaing Benoit Rolhion Nathalie de Vallée Amélie Salim Sa’ad Y Prorok-Hamon Maelle Neut Christel Campbell Batty J S?derholm Johan D Hugot Jean-Pierre Colombel Jean-Frédéric Darfeuille-Michaud Arlette | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 7 | Labor induction with the prostaglandin E1 methyl analogue misoprostol versus oxytocin:A randomized trial显示文摘 | Kaunitz AM del Valle GO | 1993 | Obstet Gynecol1993，81，： | 1 |
| 8 | Modulations of the epithelial phenotype during embryogenesis and cancer pro- gression 显示文摘 | Savagner P Boyer B Valles AM | 1994 | Cancer Treat Res1994，71，： | 1 |
| 9 | Ethanol-induced iNOS and COX-2 expression in cultured astrocytes via NF-κB显示文摘 | Blanco AM Pascual M Valles Sl | 2004 | NeuroReport2004，15，4： | 1 |
| 10 | Induction and regulation of epithelial-mesen- chymal transitions 显示文摘 | Boyer B Valles AM | 2000 | Biochem Pharmacol2000，60，8： | 1 |
| 11 | Alternative splicing in fibroblast growth factor receptor2is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells显示文摘 | Savagner P Valles AM Jouanneau J | 1994 | Mol Biol Cell1994，5，8： | 1 |
| 12 | Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes显示文摘 | VALLES SL BLANCO AM PASCUAL M | 2004 | Brain - pathol2004，14，4： | 1 |
| 13 | Therapeutic hysteroscopy:indications and techniques loulis显示文摘 | Siegler AM Valle RF Lindemann HJ | 1990 | Mis- souri Mosby1990，34，1： | 1 |
| 14 | Induction and regulation of epithelial mesenchymal transitions 显示文摘 | Boyer B Valles AM Edme N | 2000 | Biochem Pharmacol2000，60，8： | 1 |
| 15 | Comparison between Valdivia position and prone position in percutaneous nephrolithotomy显示文摘 | Amón Sesmero JH Del Valle González N Conde Rodondo C | 2008 | Actas Urol Esp2008，32，4： | 1 |
| 16 | Comparative performance of a novel herpes simplex virus type 2-specific enzyme-linked immunosorbent assay using a targeted chain oligopeptide,peptide 55显示文摘 | Al-Sulaiman AM Vallely PJ Klapper PE | 2009 | Clin Vaccine Immunol2009，16，6： | 1 |
| 17 | Alpha 2 beta 1 integrin is required for the collagen and FGF-1 induced cell dispersion in a rat bladder carcinoma cell line显示文摘 | Valles AM Boyer B Tarone G | 1996 | Cell Adhes Commun1996，4，3： | 1 |
| 18 | Induction and regulation of epithelial-mesenchymal transitions 显示文摘 | Boyer B Valles AM Edme N | 2000 | Biochem Pharmaeol2000，60，8： | 1 |
| 19 | Epitope focus, clonal composition and Th1 phenotype of the human CD4 response to the secretory mycobacterial antigen Ag85显示文摘 | Megiovanni AM Merlo A | 2001 | Clin Exp Immunol2001，23，2： | 1 |
| 20 | Epitope focus, elonal composition and Thl phenotype of the human CD4 response to the secretory mycobacterial antigen Ag85 显示文摘 | Valle MT Megiovanni AM Merlo A | 2001 | Clin Exp Immunol2001，123，2： | 1 |
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