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| 1 | Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: The follow-up study of gastrointestinal cancer patients显示文摘AIM: To study the influence of tumor removal on the serum level of IgG antibodies to tumor-associated Thomsen-Friedenreich (TF), Tn carbohydrate epitopes and xenogeneic αGal, and to elucidate on the change of the level during the follow-up as well as its association with the stage and morphology of the tumor and the values of blood parameters in gastrointestinal cancer. METHODS: Sixty patients with gastric cancer and 34 patients with colorectal cancer in stages Ⅰ-Ⅳ without distant metastases were subjected to follow- up. The level of antibodies in serum was determined by the enzyme-linked immunosorbent assay (ELISA) using synthetic polyacrylamide (PAA) glycoconjugates. Biochemical and haematological analyses were performed using automated equipment. RESULTS: In gastrointestinal cancer, the TF antibody level was found to have elevated significantly after the removal of G3 tumors as compared with the preoperative level (u = 278.5, P < 0.05). After surgery, the TF and Tn antibody level was elevated in the majority of gastric cancer patients (sign test, 20 vs 8, P < 0.05, and 21 vs 8, P < 0.05, respectively). In gastrointestinal cancer, the elevated postoperative level of TF, Tn and αGal antibodies was noted in most patients with G3 tumors (sign test, 22 vs 5, P < 0.01; 19 vs 6, P < 0.05; 24 vs 8, P < 0.01, respectively), but the elevation was not significant in patients with G1 + G2 resected tumors. The postoperative follow-up showed that the percentage of patients with G3 resected tumors of the digestive tract, who had a mean level of anti-TF IgG above the cut- off value (1.53), was significantly higher than that of patients with G1 + G2 resected tumors (χ2 = 3.89, all patients; χ2 = 5.34, patients without regional lymph node metastases; P < 0.05). The percentage of patients with a tumor in stage I, whose mean anti-TF IgG level remained above the cut-off value (1.26), was significantly higher than that of patients with the cancer in stages Ⅲ-Ⅳ (χ2 = 4.71, gastric cancer; χ2 = 4.11, gastrointestinal cancer; P < 0.05). The correlation was observed to exist between the level of anti-TF IgG and the count of lymphocytes (r = 0.517, P < 0.01), as well as between the level of anti- Tn IgG and that of serum CA 19-9 (r = 0.481, P < 0.05). No positive delayed-type hypersensitivity reaction in skin test challenges with TF-PAA in any of the fifteen patients, including those with a high level of anti-TF IgG, was observed. CONCLUSION: The surgical operation raises the level of anti-carbohydrate IgG in most patients, especially in those with the G3 tumor of the gastrointestinal tract. The follow-up demonstrates that after surgery the low preoperative level of TF antibodies may be considerably increased in patients with the carcinoma in its early stage but remains low in its terminal stages. The stage- and morphology-dependent immunosuppression affects the TF-antibody response and may be one of the reasons for unresponsiveness to the immunization with TF-antigens. | Eugeniy P Smorodin Oleg A Kurtenkov Boris L Sergeyev Kristel E Kodar Valentin I Chuzmarov Vladimir P Afanasyev | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 2 | Misfolded CuZnSOD and amyotrophic lateral sclerosis显示文摘 | Valentine J S Hart P J | 2003 | P Natl Acad Sci USA2003，100，7： | 1 |
| 3 | Carbon nanotubes: Properties and application 显示文摘 | Valentin N P | 2004 | Materials Science and Engineering2004，43，3： | 1 |
| 4 | Transvaginal doppler examination of uteri with myomas显示文摘 | Valentin L Marsal K | 1996 | J Clin Ultrasound1996，24，3： | 1 |
| 5 | Free sterol compositions from the sea cucumbers Pseudostichopus tra- chus , Holothuria (Microtele) nobilis , Holothuria scabra, Trochos- toma orientale and Bathyplotes natans 显示文摘 | VALENTINE A S LJUDMILA P P TATIANA N M | 1998 | Comp Biochem Phys B1998，120，2： | 1 |
| 6 | Isotopic evidence for the incorporation of methane-derived carbon intoforaminifera from modern methane seeps, Hydrate Ridge, Northeast Paeific 显示文摘 | Hill T M Kenett J P Valentine D L | 2004 | Geochimica et Cosmochimica Acta2004，68，22： | 1 |
| 7 | Construction of a 41 kVA Bi/Y transformer显示文摘 | Tixador P Valentin G D Maher E | 2003 | IEEE Transactions on Applied Superconductivity2003，13，2： | 1 |
| 8 | Mild therapeutic hypothermia aftercardiac arrest through continuous dialysis 显示文摘 | Karacan H Valentin A Carl P | 2009 | Ugeskr Laeger2009，171，17： | 1 |
| 9 | Strategies to reduce the risk of drug-induced QT interval prolongation : a phar- maceutical company perspective 显示文摘 | POLLARD C E VALENTIN J P HAMMOND T G | 2008 | Br J Pharmacol2008，154，7： | 1 |
| 10 | Early amino-acid administration improves preterm infant weight显示文摘 | Valentine C J Fernandez S Rogers LK Gulati P Hayes J Lore P | 2009 | J Perinatol2009，29，6： | 1 |
| 11 | Limited contribution of Doppler velocimetry to the differential diagnosis of extrauterine pelvic tumors显示文摘 | Valentin L Sladkevicius P Marrsal K | 1994 | Obstet Gynecol1994，83，3： | 1 |
| 12 | Everolimus versus azathioprine in maintenance lung transplant recipients : an international, randomized, double-blind clinical trial显示文摘 | Snell GI Valentine VG Vitulo P | 2006 | Am J Transplant2006，6，1： | 1 |
| 13 | Cost-effectiveness of intensified versus conventional multifactorial intervention in type 2 diabetes: results and projections from the Steno-2 study 显示文摘 | Gaede P Valentine WJ Palmer AJ | 2008 | Diabetes Care2008，31，8： | 1 |
| 14 | Whale sharks in Ningaloo Marine Park: managing tourism in an Australian marine protected area显示文摘 | Davis D Banks S Birtles A Valentine P Cuthill M | 1997 | Tourism Management1997，18，5： | 1 |
| 15 | Phylogenetic analysis of Xanthomonas species by comparison of partial gyrase B gene sequences显示文摘 | Neil P Valentine A John H | 2007 | International Journal of Systematic and Evolutionary Microbiology2007，57，： | 1 |
| 16 | Maxillary sinus floor elevation for implant place ment with de mineralized freeze-dried bone and bovine(Bio-Oss):a clinical study of 20 patients显示文摘 | Valentine P Abensur D | 1997 | Int J Periodont Rest Dent1997，17，： | 1 |
| 17 | Surface Structure of Stainless and Hadfield Steel after Impact Wear显示文摘 | Yuri N P Valentin G G Hans B | 2006 | Wear2006，260，6： | 1 |
| 18 | Towards multiscale func- tions: enriching finite element spaces with local but not bubble- like functions 显示文摘 | Franca L P Madureira A L F Valentin | 2005 | Comput Methods Appl Mech Engrg2005，194，2729： | 1 |
| 19 | Does three-dimensional power Doppler ultrasound help in discrimination between benign and malignant ovarian masses显示文摘 | Jokubkiene L Sladkevicius P Valentin L | 2007 | Ultrasound Obstet Gynecol2007，29，21： | 1 |
| 20 | Thermal shock resistance of SiC-BN composites显示文摘 | P G Valentine A N Palazotto R Ruh | 1986 | Advanced Ceramic Materials1986，1，1： | 1 |
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