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| 1 | SFRP4 expression correlates with epithelial mesenchymal transitionlinked genes and poor overall survival in colon cancer patients显示文摘BACKGROUND Colon cancer is among the most commonly diagnosed cancers in the United States with an estimated 97220 new cases expected by the end of 2018.It affects 1.2 million people around the world and is responsible for about 0.6 million deaths every year.Despite decline in overall incidence and mortality over the past 30 years,there continues to be an alarming rise in early-onset colon cancer cases(<50 years).Patients are often diagnosed at late stages of the disease and tend to have poor survival.We previously showed that the WNT“gatekeeper”gene,secreted frizzled-related protein 4(SFRP4),is over-expressed in early-onset colon cancer.SFRP4 is speculated to play an essential role in cancer by inhibiting the epithelial mesenchymal transition(EMT).AIM To investigate the correlation between SFRP4 expression and EMT-linked genes in colon cancer and how it affects patient survival.METHODS SFRP4 expression relative to that of EMT-linked genes and survival analysis were performed using the University of California Santa Cruz Cancer Browser interface.RESULTS SFRP4 was found to be co-expressed with the EMT-linked markers CDH2,FN1,VIM,TWIST1,TWIST2,SNAI1,SNAI2,ZEB1,ZEB2,POSTN,MMP2,MMP7,MMP9,and COL1A1.SFRP4 expression negatively correlated with the EMTlinked suppressors CLDN4,CLDN7,TJP3,MUC1,and CDH1.The expression of SFRP4 and the EMT-linked markers was higher in mesenchymal-like samples compared to epithelial-like samples which potentially implicates SFRP4-EMT mechanism in colon cancer.Additionally,patients overexpressing SFRP4 presented with poor overall survival(P=0.0293).CONCLUSION Considering the implication of SFRP4 in early-onset colon cancer,particularly in the context of EMT,tumor metastasis,and invasion,and the effect of increased expression on colon cancer patient survival,SFRP4 might be a potential biomarker for early-onset colon cancer that could be targeted for diagnosis and/or disease therapy. | Landry E Nfonsam Jana Jandova Hunter C Jecius Pamela N Omesiete Valentine N Nfonsam | 2019 | World Journal of Gastrointestinal Oncology2019，11，8： | 4 |
| 2 | Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: The follow-up study of gastrointestinal cancer patients显示文摘AIM: To study the influence of tumor removal on the serum level of IgG antibodies to tumor-associated Thomsen-Friedenreich (TF), Tn carbohydrate epitopes and xenogeneic αGal, and to elucidate on the change of the level during the follow-up as well as its association with the stage and morphology of the tumor and the values of blood parameters in gastrointestinal cancer. METHODS: Sixty patients with gastric cancer and 34 patients with colorectal cancer in stages Ⅰ-Ⅳ without distant metastases were subjected to follow- up. The level of antibodies in serum was determined by the enzyme-linked immunosorbent assay (ELISA) using synthetic polyacrylamide (PAA) glycoconjugates. Biochemical and haematological analyses were performed using automated equipment. RESULTS: In gastrointestinal cancer, the TF antibody level was found to have elevated significantly after the removal of G3 tumors as compared with the preoperative level (u = 278.5, P < 0.05). After surgery, the TF and Tn antibody level was elevated in the majority of gastric cancer patients (sign test, 20 vs 8, P < 0.05, and 21 vs 8, P < 0.05, respectively). In gastrointestinal cancer, the elevated postoperative level of TF, Tn and αGal antibodies was noted in most patients with G3 tumors (sign test, 22 vs 5, P < 0.01; 19 vs 6, P < 0.05; 24 vs 8, P < 0.01, respectively), but the elevation was not significant in patients with G1 + G2 resected tumors. The postoperative follow-up showed that the percentage of patients with G3 resected tumors of the digestive tract, who had a mean level of anti-TF IgG above the cut- off value (1.53), was significantly higher than that of patients with G1 + G2 resected tumors (χ2 = 3.89, all patients; χ2 = 5.34, patients without regional lymph node metastases; P < 0.05). The percentage of patients with a tumor in stage I, whose mean anti-TF IgG level remained above the cut-off value (1.26), was significantly higher than that of patients with the cancer in stages Ⅲ-Ⅳ (χ2 = 4.71, gastric cancer; χ2 = 4.11, gastrointestinal cancer; P < 0.05). The correlation was observed to exist between the level of anti-TF IgG and the count of lymphocytes (r = 0.517, P < 0.01), as well as between the level of anti- Tn IgG and that of serum CA 19-9 (r = 0.481, P < 0.05). No positive delayed-type hypersensitivity reaction in skin test challenges with TF-PAA in any of the fifteen patients, including those with a high level of anti-TF IgG, was observed. CONCLUSION: The surgical operation raises the level of anti-carbohydrate IgG in most patients, especially in those with the G3 tumor of the gastrointestinal tract. The follow-up demonstrates that after surgery the low preoperative level of TF antibodies may be considerably increased in patients with the carcinoma in its early stage but remains low in its terminal stages. The stage- and morphology-dependent immunosuppression affects the TF-antibody response and may be one of the reasons for unresponsiveness to the immunization with TF-antigens. | Eugeniy P Smorodin Oleg A Kurtenkov Boris L Sergeyev Kristel E Kodar Valentin I Chuzmarov Vladimir P Afanasyev | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 3 | Molecular organiza?tion of the cell wall of Candida albicans and its relation to pathogenici?ty显示文摘 | Ruiz- HerreraJ Elorza M V Valentin E | 2006 | FEMS Yeast Res2006，6，1： | 1 |
| 4 | The specific diversity indices for analysing phytoplankton succession: application to the Cabo Frio (RJ, Brazil)upwelling ecosystem显示文摘 | VALENTIN J L MACEDO - SAIDAH F E TENENBAUM D R | 1991 | Neritica1991，6，： | 1 |
| 5 | The response of straight mobile bed hannels to inbank and overbank flows 显示文摘 | Knight D W Brown F A Valentine E M | 1999 | Proc Instn of Civil Engineers Water Maritime and Energy Division London1999，136，4： | 1 |
| 6 | ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation-executive summary: A report of the American College of Cardiology/American Heart Asso- ciation Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation) 显示文摘 | Valentin F Lars E Rydrn | 2006 | Eur Heart J2006，27，8： | 1 |
| 7 | Sentinel lymph node biopsy for breast cancer using methylene blue dye manifests a short learning curve among experienced surgeons : a prospective tabular cumulative sum (CUSUM) analysis 显示文摘 | East JM Valentine CS Kanchev E Blake GO | 2009 | BMC Surg2009，9，： | 1 |
| 8 | Construction of a 41 kVA Bi/Y transformer显示文摘 | Tixador P Valentin G D Maher E | 2003 | IEEE Transactions on Applied Superconductivity2003，13，2： | 1 |
| 9 | Gray-scale ultrasound morphology in the presence or absence of intrauterine fluid and vascularity as assessed by color Doppler for discrimination between benign and malignant endometrium in women with postmenopausal bleeding 显示文摘 | Epstein E Valentin L | 2006 | Ultrasound Obstet Gynecol2006，28，1： | 1 |
| 10 | Strategies to reduce the risk of drug-induced QT interval prolongation : a phar- maceutical company perspective 显示文摘 | POLLARD C E VALENTIN J P HAMMOND T G | 2008 | Br J Pharmacol2008，154，7： | 1 |
| 11 | Comparative genomics of yeast species:new insights into their biology显示文摘 | Herrero E de la Torre MA Valentin E | 2003 | Int Microbiol2003，6，3： | 1 |
| 12 | SWOT Analysis from a resource-based view显示文摘 | VALENTIN E K | 2001 | Journal of Marketing Theory and Practice2001，9，2： | 1 |
| 13 | Enzymic resolution of an α-methylene-γ-lactonic ester显示文摘 | Pitacco G Santi A.S Valentin E | | 0，，： | 1 |
| 14 | Sentinel lymph node biopsy for breast cancer using methylene blue dye manifests a short learning curve among experienced surgeons: a prospective tabular cumulative sum (CUSUM) analysis显示文摘 | East JM Valentine CS Kanchev E | 2009 | BMC Surg2009，9，： | 1 |
| 15 | Density functional theory and electron paramagnetic resonance study on the effect of N-F codoping of TiO2 显示文摘 | Valentin C Di Finazzi E | 2008 | J Chem Mater2008，20，： | 1 |
| 16 | Density functional theory and electron paramagnetic resonance study on the effect of N-F Co-doping of TiO2 显示文摘 | Valentin C D Finazzi E Pacchioni G | 2008 | Chem Mater2008，20，11： | 1 |
| 17 | Cloning and recombinant expression of a structurally novel human se-creted phospholipaseA2显示文摘 | Gelb MH Valentin E Ghomashchi F | 2012 | J Biol Chem2012，275，51： | 1 |
| 18 | Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor显示文摘 | Kalkhoven E Valentine JE Heery DM | | 0，，： | 1 |
| 19 | Origin of photoactivity of nitrogendoped titanium dioxide under visible light显示文摘 | Livraghi S Paganini M C Giamello E Selloni A Valentin C D Pacchioni G | 2006 | Journal of the American Chemical Society2006，128，15： | 1 |
| 20 | Nature of the chemical bond between metal atoms and oxide surfaces:new evidences from spin density studies of k atoms on alkaline earth oxides显示文摘 | Chiesa M Giamello E Di Valentin C | 2005 | J Am Chem Soc2005，127，16： | 1 |
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