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| 1 | SFRP4 expression correlates with epithelial mesenchymal transitionlinked genes and poor overall survival in colon cancer patients显示文摘BACKGROUND Colon cancer is among the most commonly diagnosed cancers in the United States with an estimated 97220 new cases expected by the end of 2018.It affects 1.2 million people around the world and is responsible for about 0.6 million deaths every year.Despite decline in overall incidence and mortality over the past 30 years,there continues to be an alarming rise in early-onset colon cancer cases(<50 years).Patients are often diagnosed at late stages of the disease and tend to have poor survival.We previously showed that the WNT“gatekeeper”gene,secreted frizzled-related protein 4(SFRP4),is over-expressed in early-onset colon cancer.SFRP4 is speculated to play an essential role in cancer by inhibiting the epithelial mesenchymal transition(EMT).AIM To investigate the correlation between SFRP4 expression and EMT-linked genes in colon cancer and how it affects patient survival.METHODS SFRP4 expression relative to that of EMT-linked genes and survival analysis were performed using the University of California Santa Cruz Cancer Browser interface.RESULTS SFRP4 was found to be co-expressed with the EMT-linked markers CDH2,FN1,VIM,TWIST1,TWIST2,SNAI1,SNAI2,ZEB1,ZEB2,POSTN,MMP2,MMP7,MMP9,and COL1A1.SFRP4 expression negatively correlated with the EMTlinked suppressors CLDN4,CLDN7,TJP3,MUC1,and CDH1.The expression of SFRP4 and the EMT-linked markers was higher in mesenchymal-like samples compared to epithelial-like samples which potentially implicates SFRP4-EMT mechanism in colon cancer.Additionally,patients overexpressing SFRP4 presented with poor overall survival(P=0.0293).CONCLUSION Considering the implication of SFRP4 in early-onset colon cancer,particularly in the context of EMT,tumor metastasis,and invasion,and the effect of increased expression on colon cancer patient survival,SFRP4 might be a potential biomarker for early-onset colon cancer that could be targeted for diagnosis and/or disease therapy. | Landry E Nfonsam Jana Jandova Hunter C Jecius Pamela N Omesiete Valentine N Nfonsam | 2019 | World Journal of Gastrointestinal Oncology2019，11，8： | 4 |
| 2 | Expression ofa reflex of snapping/biting response to amino acids prior to the first exogenous feeding in salmonid alevins显示文摘 | Valentin(c)i(c) T B Lamb C F Caprio J | 1999 | Physiol Behav1999，67，4： | 1 |
| 3 | Residents' Perceptions of Community Tourism Impacts 显示文摘 | ANDERECK K L VALENTINE K M KNOPF R C | 2005 | Annals of Tourism Research2005，32，4： | 1 |
| 4 | Theory of car- bon doping of titanium dioxide显示文摘 | Di Valentin C Pacehioni G Selloni A | 2005 | Chemistry of Mate- r/a/s2005，17，26： | 1 |
| 5 | Surface sealing as; affected by various rock fragments covers in West Africa显示文摘 | Valentin C | 1994 | Catena1994，23，： | 1 |
| 6 | The activated carbon electrode: A new, experimentally verified mathematical model for the potential distribution显示文摘 | CARD J C VALENTIN G STORCK A | 1990 | J Electrochem Soc1990，137，9： | 1 |
| 7 | Photoeonversion of YFP into a CFP - like species during aeeeptor photobleaching FRET experiments 显示文摘 | VALENTIN G VERHEGGEN C PIOLOT T | 2005 | Nat Methods2005，2，1： | 1 |
| 8 | Origin of the different photoaetivity of N-doped anatase and rutile TiO2 显示文摘 | VALENTIN C D PACCHIONI G SELLONI A | 2004 | Physical Review B2004，70，08： | 1 |
| 9 | Strategies to reduce the risk of drug-induced QT interval prolongation : a phar- maceutical company perspective 显示文摘 | POLLARD C E VALENTIN J P HAMMOND T G | 2008 | Br J Pharmacol2008，154，7： | 1 |
| 10 | Early amino-acid administration improves preterm infant weight显示文摘 | Valentine C J Fernandez S Rogers LK Gulati P Hayes J Lore P | 2009 | J Perinatol2009，29，6： | 1 |
| 11 | The psychology of imitation with special ref- erence to early childhood显示文摘 | Valentine C W | 1930 | British Journal of Psychology1930，21，： | 1 |
| 12 | The pathogenesis of sepsis显示文摘 | Stearns-Kurosawa DJ Osuchowski MF Valentine C | 2011 | Annu Rev Pathol2011，6，： | 1 |
| 13 | In vitro antiplasmodial activity of extracts of Alchomea cordifolia and identification of an active constituent:ellagic acid显示文摘 | Banzouzi J T Prado R Menan H Valentin A Roumestan C Mallie M Pelissier Y Blache Y | 2002 | Journal of Ethnopharmacology2002，81，： | 1 |
| 14 | On the security of to-day* s online electronic banking systems 显示文摘 | JORIS C VALENTIN D DANNY D C | 2002 | Computers & Securi-ty2002，21，3： | 1 |
| 15 | Gully erosion; Impacts, factors andcontrol 显示文摘 | Valentin C Poesen J Yong Li | 2005 | Catena2005，63，： | 1 |
| 16 | Effects of bortezomib on human neuroblastoma cells in vitro and in a metastatic xenograft model 显示文摘 | Valentiner U Haane C Nehmann N | 2009 | Anticancer Res2009，29，4： | 1 |
| 17 | Metabolism of N-Butyl Benzyl Phthalate in the Female wistar Rat显示文摘 | Nativelle K Picard I Valentin J C | 1999 | Food and Chemical Toxicology1999，37，： | 1 |
| 18 | Surface Sealing as Affected by Various Rock Fragment Covers in West Africa 显示文摘 | VALENTIN C | 1994 | Catena1994，23，： | 1 |
| 19 | Identifi-cation of novel methane-,ethane-,and propane-oxidizing bacte-ria at marine hydrocarbon seeps by stable isotope probing显示文摘 | REDMOND M C VALENTINE D L SESSIONS A L | 2010 | Applied and Environmental Microbiology2010，76，19： | 1 |
| 20 | Antioxidant potential and per- oxidative state of olden smoothee apples treated with 1- methylcyclopropene 显示文摘 | Vilaplana R Valentines C | 2006 | J AMER Soc Hort Sci2006，13，1： | 1 |
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