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| 1 | Identification of CD13,CD107a,and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-de-pendent upregulation显示文摘Using two-colour flow cytometry >200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens (HLDA8) have been analyzed for their reactivity with resting and activated CD203c+ basophils. Four antibodies either non-reactive or weakly reactive with resting basophils exhibited an increased reactivity with basophils activated by anti-IgE-mediated cross-linking of the high affinity IgE receptor (FcεRI). These include antibod- ies against CD164 (WS-80160, clone N6B6 and WS-80162, clone 67D2), as well as two reagents with previously unknown specificities that were identified as CD13 (WS-80274, clone A8) and CD107a (WS-80280, clone E63-880). The activation patterns followed either the “CD203c-like” or “CD63-like” activation profile. The CD203c profile is characterized by a rapid and significant upregulation (of CD13, CD164, and CD203c), reaching maximum levels after 5- 15 min of stimulation. The phosphoinositide-3-kinase (PI3K)-specific inhibitor wortmannin inhibited the upregulation of these markers whereas 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced a rapid and FcεRI-independent upregulation within 1-2 min. In the CD63 profile, maximum upregulation (of CD63 and CD107a) was detected only after 20-40 min, and upregulation by TPA reached maximum levels after 60 min. In summary, our data identify CD13, CD107a, and CD164 as novel basophil-activation antigens. Based on time kinetics of upregulation, we hypothesize that molecules of the “CD203c group” and the “CD63 group” are linked to two different mechanisms of basophil activation. | Florian HENNERSDORF Stefan FLORIAN Andreas JAKOB Katharina BAUMGRTNER Karoline SONNECK Alfred NORDHEIM Tilo BIEDERMANN Peter VALENT Hans-Jrg BüHRING | 2005 | Cell Research2005，15，5： | 9 |
| 2 | Roles for rice membrane dynamics and plasmodesmata during biotrophic invasion by the blast fungus 显示文摘 | Kankaaala P Czymmek K Valent B | 2007 | Plant Cell2007，19，： | 1 |
| 3 | Microencapsulated chitosan-dextran sulfate nanoparticles for controlled delivery of bioactive molecules and cells in bone regeneration显示文摘 | Valente J F A Gaspar V M Antunes B P | 2013 | Polymer2013，54，： | 1 |
| 4 | Amplification of the MLL gene on double minutes,a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome显示文摘 | STREUBEL B VALENT P JAGER U | 2000 | Genes Chromosomes Cancer2000，27，： | 1 |
| 5 | Host pathogen interactions in plants, when exposed to 01igosaccharides of fungal origin, de- fend themselves by accumulatingantibiotics显示文摘 | AlbersheimP Valent B S | 1978 | J Cell Biol1978，78，： | 1 |
| 6 | Magnaporthe grisea Genes for Pathogenicity and Virulence Identified Through a Series of Backcrosses显示文摘 | VALENT B FARRALL L CHUMELY F G | 1991 | Genetics1991，127，1： | 1 |
| 7 | Magnaporthe grisea genes for pathogenicity and virulence identified through a se- ries of baekcrosses 显示文摘 | VALENT B FARRALL L CHUMLEY F G | 1991 | Genetics1991，127，： | 1 |
| 8 | lnterleukin-18 induces human cardiac endothelial cell death via a novel signaling pathway invol- ving NF-kappaB-dependent PTEN activation显示文摘 | Chandrasekar B Valente AJ Freeman GL | 2006 | Bioch Bioph Res Com- mun2006，339，3： | 1 |
| 9 | EMMPRIN activates multiple transcription faetors in eardiomyocytes, and induces interleukin-18 expression via Rael-dependent PI3K/ Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling 显示文摘 | Venkatesan B Valente A J Prabhu SD | 2010 | J Mol Cell Cardiol2010，49，4： | 1 |
| 10 | Recent advances in rice blast effector research显示文摘 | Valent B Khang CH | 2010 | Current Opinion in Plant Biology2010，13，4： | 1 |
| 11 | The PWL host specificity gene family in the blast fungus Magnaporthe grisea 显示文摘 | Kang S Sweigard J A Valent B | 1995 | MPMI1995，8，： | 1 |
| 12 | Isolation of the mating-type genes of the phytopathogenic fungus Magnaporthe grisea using genomic subtraction显示文摘 | Kang S Chumley F G Valent B | 1994 | Genetics1994，138，： | 1 |
| 13 | Host-pathogen interactions in plants, when exposed to oligosaccharides of fungal origin, defend themselves by accumulating antibiotics 显示文摘 | Albersheim P Valent B S | 1978 | J Cell Biol1978，78，3： | 1 |
| 14 | Rice blast as a model system for plant pathology显示文摘 | Valent B | 1990 | Phytopathology1990，80，： | 1 |
| 15 | The proatherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptorassociated factor 6, c-Src, phosphatidylinositol 3-ki- nase, Akt, c-Jun N-terminal kinase, and activator protein-1 signaling显示文摘 | Chandrasekar B Mummidi S Valente AJ | 2005 | J Biol Chem2005，280，26： | 1 |
| 16 | Molecular genetic analysis of the rice blast fungus,Magnaporthe grisea显示文摘 | VALENT B CHUMLEY F G | 1991 | Annual Review of Phytopathology1991，29，： | 1 |
| 17 | CaTiO3-based ceramics: microstructure development and dielectric properties显示文摘 | SUVOROV D VALENT M JANCAR B | 2001 | Acta Chim Slov2001，48，： | 1 |
| 18 | Breaking and Entering - host Penetration by the Fungal Rice Blast Pathogen Magnaporthe grisea显示文摘 | HOWARD R J VALENT B | 1996 | Annu Rev Microbiol1996，50，： | 1 |
| 19 | EMMPRIN activates multiple transcription factors in cardiomyocytes , and induces interleukin-18 expression via Rac 1-dependent PI3K1 Aktl IKKlNF-kappaB and MKK7/JNKI AP-1 signaling显示文摘 | VENKA TESAN B VALENTE A J PR ABHU S D | 2010 | J Mol Cell Cardiol2010，49，4： | 1 |
| 20 | Ultrastruetrual biologic effects of sonography with pulse inversion and microbubble contrast in rabbit liver 显示文摘 | Caruso G Valention B Salvaggio G | 2005 | J Clin Ultrasound2005，33，3： | 1 |
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