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| 1 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 2 | Management of autoimmune hepatitis:Focus on pharmacologic treatments beyond corticosteroids显示文摘In autoimmune hepatitis, patients who are intolerant or with toxicity experience, non-responders, relapsers or refractory are challenging. Non-standard drugs are being tried to preemptively avoid corticosteroid-related side effects. Prognosis and quality of life of life rely on treatment optimization. Recently, emergence of powerful immunosuppressive agents, mainly from liver transplantation, challenged the supremacy of the corticosteroid regime and promise greater immunosuppression than conventional medications, offer site-specific actions and satisfactory patient tolerance. Successes in experimental models of related diseases have primed these molecular interventions. We performed a literature review on alternative treatments. Azatioprine intolerance is the principal indication for mycophenolate use butit can be used as a front-line therapy. Cyclosporine A and tacrolimus have been tested for non-responders or relapsers. Rituximab may be used as salvage therapy. Anti-tumor necrosis factor-alpha agents may be used for incomplete responses or non-responders. Methotrexate is possibly an alternative for induction of remission and maintenance in refractory patients. Cyclophosphamide has been included in the induction regimen with corticosteroids. Ursodeoxycholic acid action is mainly immunomodulatory. Non-standard treatments are coming slowly to the attention, but its use should be cautious performed by experienced centers. | Marta Casal Moura Rodrigo Liberal Hélder Cardoso Ana Maria Horta e Vale Guilherme Macedo | 2014 | World Journal of Hepatology2014，6，6： | 2 |
| 3 | Feasibility of occipital condyle smvw placement for occipitocervical fixation: a cadaveric study and description of a novel technique显示文摘 | Uribe JS Ramos E Vale F | 2008 | J Spinal Dis- ord Tech2008，21，8： | 1 |
| 4 | Prominence of the Eustachian valve in paradoxical embolism显示文摘 | Vale TA Newton JD Orchard E | 2011 | Eur J Echocardiogr2011，12，1： | 1 |
| 5 | Derivation of predicted no effect concentrations (PNEC) for marine environmental risk assessment:Application of different approaches to the model contaminant Linear Alkylbenzene Sulphonates (LAS) in a sitespecific environment显示文摘 | Hampel M González-Mazo E Vale C | | 0，，04： | 1 |
| 6 | Hyperbranched polyglycerol electrospun nanofibers for wound dressing applica tions显示文摘 | Vargas E A T Do Vale Baraeho N C De Brilo J | 2010 | Aeta biornaterialia2010，6，3： | 1 |
| 7 | Left ventricular electro- mechanical mapping to assess efficacy of phVEGF (165) gene transfer for therapeutic angiogenesis in chronic myoeardial isehemia 显示文摘 | Vale P R Losordo D W Milliken C E | 2000 | Circulation2000，102，9： | 1 |
| 8 | Effects of rice growth stages and silicon on sheath blight development 显示文摘 | Rodrigues F A Vale F X R Datnoff L E | 2003 | Phytopathology2003，93，： | 1 |
| 9 | A real-time MAC protocol for wireless sensor net-works:Virtual TDMA for sensor(VTS)显示文摘 | Egea E Vales J | 2006 | Lecture Notes inComputer Science2006，7，2： | 1 |
| 10 | The canny detector with edge region focusing using an anisotropic diffusion process显示文摘 | GALVANIN E A S DO VALE G M DAL POZ A P | 2006 | Pattern Recognition and Image Analysis2006，16，4： | 1 |
| 11 | Activin-A in myometrium:characterization of the actions on myometrial cells显示文摘 | Ciarmela P Wiater E Vale W | 2008 | Endocrinology2008，149，5： | 1 |
| 12 | Electromyographic monitoring and its anatomical implications in minimally invasive spine surgery显示文摘 | Uribe JS Vale FL Dakwar E | 2010 | Spine2010，35，26： | 1 |
| 13 | Mouse B7-H3 induces antitumor immunity显示文摘 | Sun X Vale M Leung E | 2003 | Gene Ther2003，10，20： | 1 |
| 14 | Dermatofibrosarcoma protuberans:a clinicopathological study of 20 cases显示文摘 | Oliveira-Soares R Viana I Vale E | 2002 | J Eur Acad Dermatol Venereol2002，16，： | 1 |
| 15 | Evaluation of pH levels and calcium ion release in various calcium hydroxide endodontie dressings 显示文摘 | de Andrade Ferreira FB Silva E Souza P de A do Vale MS | 2004 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2004，97，3： | 1 |
| 16 | Mouse B7-H3 induces antitumor immunity 显示文摘 | Sun X Vale M Leung E | 2003 | Gene Ther2003，10，20： | 1 |
| 17 | Metabotropic glutamate receptor antagonists but not NMDA antagonists affect conditioned taste aversion acquisition in the parabrachial nucleus of rats显示文摘 | Vales K Zach P Bielavska E | 2006 | Exp Brain Res2006，169，1： | 1 |
| 18 | Randomized, singleblind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia显示文摘 | Vale P R Losordo D W Milliken C E | 2001 | Circulation2001，103，17： | 1 |
| 19 | Position paper on urine alkalinization显示文摘 | Proudfoot A T Krenzelok E P Vale J A | 2004 | J Toxicol Clin Toxicol2004，42，1： | 1 |
| 20 | Genotoxic analysis of silver nanoparticles in Drosophila显示文摘 | Demir E Vales G Kaya B | 2011 | Nanotoxicology2011，5，3： | 1 |
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