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| 1 | Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI显示文摘AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVueüà-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrastenhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The f inal diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVueüà -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specif icity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specif icity of CEUS for the identif ication of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVueüà-enhanced sonography emerges as the most sensitive, most specif ic and thus most accurate imaging modality for the characterization of focal liver lesions. | Hervé Trillaud Jean-Michel Bruel Pierre-Jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis | 2009 | World Journal of Gastroenterology2009，15，30： | 34 |
| 2 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 3 | Rescue Surgery for Unresectable Colorectal Liver Metastases Downstaged by Chemotherapy: A Model to Predict Long-term Survival显示文摘 | René Adam Valérie Delvart Gérard Pascal Adrian Valeanu Denis Castaing Daniel Azoulay Sylvie Giacchetti Bernard Paule Francis Kunstlinger Odile Ghémard Francis Levi Henri Bismuth | 2004 | Annals of Surgery2004，，4： | 2 |
| 4 | Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease显示文摘 | Gentric Géraldine Maillet Vanessa Paradis Valérie Couton Dominique L’Hermitte Antoine Panasyuk Ganna Fromenty Bernard Celton-Morizur Séverine Desdouets Chantal | 2015 | Journal of Clinical Investigation2015，，： | 2 |
| 5 | Diag-nostic value of CT,PET and combined PET/CT performed with low-dose unenhanced CT and full-dose enhanced CT in the initial staging of lymphoma显示文摘 | Pinilla I Gómez-León N Del Campo-Del Val L | 2011 | Q J Nucl Med Mol Imaging2011，55，5： | 1 |
| 6 | Intracellular Pool of Vascular Endothelial Growth Factor in Human Neutrophils显示文摘 | Murielle G Olivier B Valérie A | 1997 | Blood1997，90，10： | 1 |
| 7 | The role of bacterial vaginosis in preterm labor and preterm birth: A case-control study 显示文摘 | Damien S I Val rie D Fran oise L G | 2002 | Euro J Obstet Gynecol Reprod Biol2002，101，1： | 1 |
| 8 | Life-cycle cost analysis of reinforced concrete structures in marine environments显示文摘 | Dimitri V Val Mark G Stewart | 2003 | Structural Safety2003，25，： | 1 |
| 9 | Life-cycle cost analysis of reinforced concrete structures in marine environments显示文摘 | Val D V Stewart M G | 2003 | Structural Safety2003，25，： | 1 |
| 10 | Multiple Limit States and Expected Failure Costs for Deteriorating Reinforced Concrete Bridges显示文摘 | Dimitr V Val | 2003 | Journal of Bridge Engineering ASCE2003，，11： | 1 |
| 11 | Proteomics gives insight into the regulatory function of chloroplast thioredoxins显示文摘 | BALMER Y KOLLER A DEL VAL G | | 0，，： | 1 |
| 12 | Expression of cell cycle control proteins in primary colorectal tumors does not always predict expression in lymph node metastases显示文摘 | McKay Joy J Douglas Val G | 2000 | Clin Cancer Res2000，6，3： | 1 |
| 13 | Effect of reinforcement corrosion on reliability of highway bridges显示文摘 | Val D V Stewart M G Melchers R E | 1998 | Engineering Structures1998，20，11： | 1 |
| 14 | Role of load history in reliability-based decision analysis of aging bridges显示文摘 | Stewart M G Val D V | 2004 | Journal of Structural Engineering2004，125，7： | 1 |
| 15 | Use of ultrasonic energy for intensification of the biopreparationof greige cotton显示文摘 | YACHMENEV Val G BLANCHARD Eugene J LAMBERTAllan H | 2004 | Ultrasonic2004，42，： | 1 |
| 16 | Effect of reinforcement corrosion on reliability of highway bridges 显示文摘 | Val D V Stewart M G Melchers R E | 1998 | Engineering Structures1998，20，11： | 1 |
| 17 | Role of load history in reliability-based decision analysis of aging bridges显示文摘 | Mark G Stewart Dimitri V Val | 1999 | Journal of Structural Engineering1999，125，7： | 1 |
| 18 | Bcl-2 expre- ssion in breast cancer: a comparative study at the mRNA and protein level显示文摘 | Martmez-Arribas F Alvarez T Del Val G | 2007 | Anticancer Res2007，27，1： | 1 |
| 19 | Life-cycle cost analysis of reinforced concrete structures in marine environments显示文摘 | Val D V Stewart M G | 2003 | Structural Safety2003，25，： | 1 |
| 20 | Life - cycle cost analysis of rein- forced concrete structures in marine environments 显示文摘 | Val D V Stewart M G | 2003 | Structural Safety2003，25，4： | 1 |
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