|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current clinical approach to achalasia显示文摘Idiopathic achalasia is a rare primary motility disorder of the esophagus. The classical features are incomplete relaxation of a frequently hypertensive lower esophageal sphincter (LES) and a lack of peristalsis in the tubular esophagus. These motor abnormalities lead to dysphagia, stasis, regurgitation, weight loss, or secondary respiratory complications. Although major strides have been made in understanding the pathogenesis of this rare disorder, including a probable autoimmune mediated destruction of inhibitory neurons in response to an unknown insult in genetically susceptible individuals, a definite trigger has not been identified. The diagnosis of achalasia is suggested by clinical features and conf irmed by further diagnostic tests, such as esophagogastroduodenoscopy (EGD), manometry or barium swallow. These studies are not only used to exclude pseudoachalasia, but also might help to categorize the disease by severity or clinical subtype. Recent advances in diagnostic methods, including high resolution manometry (HRM), might allow prediction of treatment responses. The primary treatments for achieving long-term symptom relief are surgery and endoscopic methods. Although limited high-quality data exist, it appears that laparoscopic Heller myotomy with partial fundoplication is superior to endoscopic methods in achieving long-term relief of symptoms in the majority of patients. However, the current clinical approach to achalasia will depend not only on patients' characteristics and clinical subtypes of the disease, but also on local expertise and patient preferences. | Alexander J Eckardt Volker F Eckardt | 2009 | World Journal of Gastroenterology2009，15，32： | 20 |
| 2 | Is the schatzki ring a unique esophageal entity?显示文摘AIM:To study,whether the association of Schatzki rings with other esophageal disorders support one of the theories about its etiology.METHODS:From 1987 until 2007,all patients with newly diagnosed symptomatic Schatzki rings (SRs) were prospectively registered and followed.All of them underwent structured interviews with regards to clinical symptoms,as well as endoscopic and/or radiographic examinations.Endoscopic and radiographic studies determined the presence of an SR and additional morphological abnormalities.RESULTS:One hundred and sixty-seven patients (125 male,42 female) with a mean age of 57.1±14.6 years were studied.All patients complained of intermittent dysphagia for solid food and 113 (79.6%) patients had a history of food impaction.Patients experienced symptoms for a mean of 4.7±5.2 years before diagnosis.Only in 23.4% of the 64 patients who had endoscopic and/or radiological examinations before their first presentation to our clinic,was the SR previously diagnosed.At presentation,the mean ring diameter was 13.9±4.97 mm.One hundred and sixty-two (97%) patients showed a sliding hiatal hernia.Erosive reflux esophagitis was found in 47 (28.1%) patients.Twenty-six (15.6%) of 167 patients showed single or multiple esophageal webs;five (3.0%) patients exhibited eosinophilic esophagitis;and four (2.4%) had esophageal diverticula.Four (7%) of 57 patients undergoing esophageal manometry had nonspecific esophageal motility disorders.CONCLUSION:Schatzki rings are frequently associated with additional esophageal disorders,which support the assumption of a multifactorial etiology.Despite typical symptoms,SRs might be overlooked. | Michaela Müller Ines Gockel Philip Hedwig Alexander J Eckardt Kathrin Kuhr Jochem Knig Volker F Eckardt | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 3 | Quantitative determination of metabolic fluxs during coutilization of two carbon sources:comparative analysis with Corynebacterium glutamicum durin growth on acetate and glucose显示文摘 | Volker F Wendisch Albert A DE Graaf Hermann Sahm | 2000 | Journal of Biotechnology2000，，： | 1 |
| 4 | Thomashow components of the Arabidopsis C repeat/dehydration responsive element bindingfactor cold-response pathway are conserved in Brassica napus and other plant species显示文摘 | KIRSTEN R J SUSANNE K KEENAN L A XIN Z VOLKER H JAMES Z Z THOMAS D MICHAEL F | 2001 | Plant Plzysiology2001，127，3： | 1 |
| 5 | Matching Spatial Data Sets: a Statistical Approach显示文摘 | Volker W Dieter F | 1999 | International Journal of Geographical Information Science1999，13，5： | 1 |
| 6 | Lymphocyte apotosis after exhaustive and moderate exercise 显示文摘 | Mooren F C Bloming D Lechtermann A Lerch M M Volker K | 2002 | JAppl Physiol2002，93，1： | 1 |
| 7 | Influence of nonionic surfactants on bioavailability and biodegradation of polycyclic aromatic hydrocarbons显示文摘 | Volkering F Breure AM van Andel JG | 1995 | Applied and Environmental Microbiology1995，61，5： | 1 |
| 8 | Orientation Dependence of Dislocation Structures and Deformation Mechanisms in Creep Deformed CMSX-4 Single Crystals 显示文摘 | Volker S Monika F K | 1998 | Materials Science and Engineer- ing1998，245，： | 1 |
| 9 | Capillary pressure in fresh cement-based materials and identification of the air entry value显示文摘 | VOLKER S MARKUS S ROBERT F | 2008 | Cement and Concrete Composites2008，30，7： | 1 |
| 10 | Simultane- ous in situ measurement o{ CO, H20 and gas temper- atures in a full-sized coal-fired power plant by near-in- frared diode lasers显示文摘 | HOLGER T THOMAS F VOLKER E | 2003 | Applied Optics2003，42，12： | 1 |
| 11 | Randomized comparison of FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment of KRAS wild-type metastatic colorectal cancer:German AIO study KRK-0306 (FIRE-3)显示文摘 | Volker H Ludwig F Thomas D | 2013 | J Clin Oncol2013，31，： | 1 |
| 12 | Loss of ovarian reserve after uterine artery emholization: a randomized comparison with hysterectomy 显示文摘 | HEHENKAMP W J VOLKERS N A BROEKMANS F J | 2007 | Hum Re- prod2007，22，7： | 1 |
| 13 | The geometric meaning of Nielson affine invariant norm显示文摘 | Mendelin L F Degen Volker Milbrandt | 1997 | Computer Aided Geomertic Design1997，15，： | 1 |
| 14 | Thrombin has biphasic effects on the nitric xxide-cGMP pathway in endothelial cells and contributes to experimental pulmonary hypertension显示文摘 | Katrin F Nickel Volker L | 2013 | Plos One2013，8，63： | 1 |
| 15 | Routine lead isotope determinations using a lead-207-1ead-204 double spike: A long-term assessment of analytical precision and accuracy 显示文摘 | Woodhead J Volker F McCulloch M | 1995 | Analyst1995，120，1： | 1 |
| 16 | Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex显示文摘 | KOJI O VOLKER B STEFANIE F | 2010 | The Journal of Immunology2010，9，： | 1 |
| 17 | Calibration of a scanning probe microscope by the use of an interference -holographic position measurement system 显示文摘 | VOLKER K S F LUDWIG J B | 2003 | Measurement Science and Technology2003，14，： | 1 |
| 18 | Antitumor effects of the cytotoxic luteinizing hormone releasing hormone analog AN-152 on human endometrial and ovarian cancers xenografted into nude mice显示文摘 | Grundker Volker P Griesinger F | 2002 | Am J Obstet Gynecol2002，187，3： | 1 |
| 19 | C - reactive protein levels determine systemic nitric oxide bioavailability in patients with coronary artery disease 显示文摘 | Stephan F Susanne B Volker S | 2004 | European Heart Jourmal2004，25，： | 1 |
| 20 | Complications and adverse effects of colonoscopy with selective sedation显示文摘 | Volker F Eckardt Gerd Kanzlcr | 1999 | Gastrointcst Endosc1999，49，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员