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| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | CD28/CTLA-4/B7 and CD40/CD40L costimulation and activation of regulatory T cells显示文摘Costimulatory signals are crucial for T cell activation. Attempts to block costimulatory pathways have been effective in preventing unwanted immune reactions. In particular, blocking the CD28/cytotoxic T lymphocyte antigen(CTLA)-4/B7 interaction(using CTLA-4Ig) and the CD40/CD40 L interaction(using anti-CD40 L antibodies) prevents T cell mediated autoimmune diseases, transplant rejection and graft vs host disease in experimental models. Moreover, CTLA-4Ig is in clinical use to treat rheumatoid arthritis(abatacept) and to prevent rejection of renal transplants(belatacept). Under certain experimental conditions, this treatment can even result in tolerance. Surprisingly, the underlying mechanisms of immune modulation are still not completely understood. We here discuss the evidence that costimulation blockade differentially affects effector T cells(Teff) and regulatory T cells(Treg). The latter are required to control inappropriate and unwanted immune responses, and their activity often contributes to tolerance induction and maintenance. Unfortunately, our knowledge on the costimulatory requirements of Treg cells is very limited. We therefore summarize the current understanding ofthe costimulatory requirements of Treg cells, and elaborate on the effect of anti-CD40 L antibody and CTLA-4Ig treatment on Treg cell activity. In this context, we point out that the outcome of a treatment aiming at blocking the CD28/CTLA-4/B7 costimulatory interaction can vary with dosing, timing and underlying immunopathology. | Isabel T Vogel Stefaan W Van Gool Jan L Ceuppens | 2014 | World Journal of Immunology2014，4，2： | 3 |
| 3 | Surgery for Ductal Adenocarcinoma of the Pancreatic Head: Staging, Complications, and Survival after Regional versus Extended Lymphadenectomy显示文摘 | Doris Henne-Bruns Ilka Vogel Jutta Lüttges Günter Kl?ppel Bernd Kremer | 2000 | World Journal of Surgery2000，，5： | 2 |
| 4 | Characterising humic acid fouling of nanofiltration membrane using bisphenol A as a molecular indicator 显示文摘 | Nghiem L D Vogel D Khan S | 2008 | Water Research2008，42，： | 1 |
| 5 | Abiotic and Biotic Trans-formations of 1,1,1-Trichloroethane under MethanogenicConditions显示文摘 | VOGEL T M MCCARTY P L | 1987 | Environmental Science and Technology1987，21，12： | 1 |
| 6 | 10Be profiles in sea water显示文摘 | KUSAKABE M KU T L VOGEL J | 1982 | Nature1982，299，： | 1 |
| 7 | Virtual Community Informatics: A Review and Research Agenda显示文摘 | Lee F S L Vogel D Limayem M | 2003 | Journal of Information Technology and Applica- tion2003，5，1： | 1 |
| 8 | Mastitis in the first year postpartum 显示文摘 | Vogel A Hutchison B L Mitchell E A | 1999 | Birth1999，26，4： | 1 |
| 9 | Impact of reduced lignin on plant fitness显示文摘 | Pedersen J F Vogel K P Funnell D L | 2005 | Crop Sci2005，45，3： | 1 |
| 10 | Characterising humic acid fouling of nanofiltration membranes using bisphenol A as a molecular indicator显示文摘 | Nghiem L D Vogel D Khan S | 2008 | Water Res2008，42，15： | 1 |
| 11 | Oscillation-free operator splitting method for semilinear diffusion equations显示文摘 | Harwood R C Zhang L K Vogel G M | 2013 | Journal of Ap- plied Mathematics and Computation2013，18，7： | 1 |
| 12 | AtHsp70-15-deficient Arabidopsis plants are characterized by reduced growth, a constitutive cytosolic protein response and enhanced resistance to TuMV 显示文摘 | Jungkunz I Link K Vogel F Voll L M Sonnewald S Sonnewald U | 2011 | Plant Journal2011，66，： | 1 |
| 13 | Rotor-stator interactionsin a four-stage low-speed axial compressor: Part H un-steady aerodynamic forces of rotor and stator blades显示文摘 | Mailach R Muller L Vogeler K | 2004 | Journal of Turbomachinery2004，126，4： | 1 |
| 14 | The heart and pediatric rheumatology显示文摘 | Vogel T Kitcharoensakkul M Fotis L | 2014 | Rheum Dis Clin Noah Am2014，40，1： | 1 |
| 15 | Se- vere oral allergy syndrome and anaphylactic reactions caused by a Bet vl- related PR-10 protein in soybean, SAM22显示文摘 | KLEINE-TEBBE J VOGEL L CROWELL D N | 2002 | Journal of Allergy and Clinical Immunology2002，110，5： | 1 |
| 16 | Sex differences in the use of demand and withdraw behavior in marriage: Examining the social structure hypothesis 显示文摘 | David L Vogel Megan J Murphy Ronald J Wemer-Wilson | 2007 | Journal of Counseling Psychology2007，54，2： | 1 |
| 17 | IFN-beta-dependent inhibition of tumor growth by the vascular disrupting agent 5, 6-dimethylxanthe- none-d-acetic acid (DMXAA) 显示文摘 | Roberts Z J Ching L M Vogel S N | 2008 | J Interferon Cytokine Res2008，28，3： | 1 |
| 18 | The small RNA IstR inhibits synthesis of an SOS-induced toxic peptide显示文摘 | Vogel J Argaman L Wagner E G H | 2004 | Curr Biol2004，14，24： | 1 |
| 19 | Diagnosis of pancreatic cancer and predictiou of unresectability using the tumor associated antigen CA19 - 9 显示文摘 | Forkm CE Lam biase L Vogel SB | 1994 | Pancreas1994，9，6： | 1 |
| 20 | An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac toxin显示文摘 | GAHAN L J PAUCHET Y VOGEL H | | 0，，12： | 1 |
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