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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | DNA methylation as a regulatory mechanism for gene expression in mammals显示文摘 | Serman A Vlahovic M Serman L | 2006 | Coll Antropol2006，30，3： | 1 |
| 3 | Micro RNA-31 controls hair cycle-associated changes in gene expression pro- grams of the skin and hair follicle显示文摘 | Mardaryev A N Ahmed M I Vlahov N V | 2010 | The FASEB Journal2010，24，10： | 1 |
| 4 | The epidemiology of post-traumatic Stress disorder after disasters 显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，： | 1 |
| 5 | Synthesis and biological evaluation of EC140:a no- vel folate-targeted vinca alkaloid conjugate 显示文摘 | LEAMON C P REDDY J A VLAHOV I R | 2006 | Bio- conjug Chem2006，17，5： | 1 |
| 6 | Adjunctive effect of hyperbaric oxygen treatment after thrombolysis on left ventricular function in patients with acute myocardial infarction显示文摘 | Dekleva M Neskovic A Vlahovic A | | 0，，： | 1 |
| 7 | The epidemiology of post-traumatic stress disorder after disasters显示文摘 | Galea S Nandi A Vlahov D | | 0，，01： | 1 |
| 8 | Dilated heart muscle disease associated with HIV infection显示文摘 | Herskowitz A Willoughby S B Vlahov D | 1995 | Eur Heart J1995，，： | 1 |
| 9 | The epidemiology of Post- traumatic stress disorder after disasters 显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，11： | 1 |
| 10 | The epidemiology of post - traumatle stress disorder after disasters显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，： | 1 |
| 11 | The epidemidogy of post-traumatic stress disorder after disasters显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，1： | 1 |
| 12 | The epidemiology of post-traumatic stress disorder after disasters 显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，1： | 1 |
| 13 | Preclinical antitumor activity of a novel folatetargeted dual drug conj ugate显示文摘 | Leamon C P Reddy J A Vlahov I R Westrick E Dawson A Dorton R | 2007 | Mol Pharm2007，4，： | 1 |
| 14 | The epidemiology of post-traumatic stress disorder after disasters显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，： | 1 |
| 15 | The epidemiology of post-traumatic stress disorder after disasters 显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiologic Reviews2005，27，1： | 1 |
| 16 | Electron Ef- fective Mass Of Gabs Double - Concentric Quantum Rings 显示文摘 | FILIKHIN I DEYNEKA E VLAHOVIC A | 2007 | Nanotech2007，，1： | 1 |
| 17 | Synthesis and Biological Evaluation of EC20: A New Folate-Derived, ^99Tc^m-Based Radiopharmaceutical显示文摘 | Leamon C P Parker M A Vlahov I R | 2002 | Bioconjugate Chem2002，13，： | 1 |
| 18 | The long-term outcome of a personal network-oriented HIV prevention intervention for injection drug users: the SAFE Study 显示文摘 | Latkin C A Mandell W Vlahov D | 1996 | American Journal of Community Psychology1996，24，3： | 1 |
| 19 | A statistical analysis of earthquake focal mechanisms and epicenter locations in the eastern Tennessee seismic zone显示文摘 | Chapman M C Powell C A Vlahovic G | | 0，，6： | 1 |
| 20 | Maturity of human immunode?ficiency virus infection and incubation period of acquired immunode?ficiency syndrome in injecting drug users显示文摘 | Alcahes P Munoz A Vlahov D | 1994 | Ann Epidemiol1994，4，1： | 1 |
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