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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Association be-tween injection practices and duration of injection among re-cently initiated injection drug users显示文摘 | Becker Buxton M Vlahov D Strathdee SA | 2004 | Drug Alcohol Depend2004，75，2： | 1 |
| 3 | The epidemiology of post-traumatic Stress disorder after disasters 显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，： | 1 |
| 4 | Attitudes Toward Hrq Treatments Influence Unsafe Sexual and Injection Practices among Injecting Drug Users 显示文摘 | Tun W Celentano DD Vlahov D | 2003 | AIDS2003，17，13： | 1 |
| 5 | Correlates of enrollment in methadone maintenance treatment programs differ by HIVserostatus显示文摘 | Shah NG Celentano DD Vlahov D | 2000 | AIDS2000，14，13： | 1 |
| 6 | Urban health:evidence,challenge,and directions显示文摘 | Galea S Vlahov D | | 0，，： | 1 |
| 7 | Re- gioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid 显示文摘 | VLAHOV I R VITE G D KLEINDL P J | 2010 | Bioorg Med Chem Lett2010，20，15： | 1 |
| 8 | The epidemiology of post-traumatic stress disorder after disasters显示文摘 | Galea S Nandi A Vlahov D | | 0，，01： | 1 |
| 9 | Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV epidemiology research study 显示文摘 | ICKOVICS J R HAMBURGER M E VLAHOV D | 2001 | J Am Med Assoc2001，285，11： | 1 |
| 10 | Effect of human immunodeficiency virus on hepatitis C virus infection among injecting drug users显示文摘 | Thomas DL Shih JW Vlahov D | 1996 | J Infect Dis1996，174，： | 1 |
| 11 | Urbanization,urbancity,and health显示文摘 | Vlahov D Galea S | 2002 | Journal of Urban Health2002，79，4： | 1 |
| 12 | Dilated heart muscle disease associated with HIV infection显示文摘 | Herskowitz A Willoughby S B Vlahov D | 1995 | Eur Heart J1995，，： | 1 |
| 13 | War and anxiety disorder显示文摘 | Vlahov D Galea S | 2004 | Epidemiology2004，15，2： | 1 |
| 14 | The epidemiology of Post- traumatic stress disorder after disasters 显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，11： | 1 |
| 15 | The epidemiology of post - traumatle stress disorder after disasters显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，： | 1 |
| 16 | Suspected determinants of enrollment into detoxification and methadone maintenance treatment among injecting drug users显示文摘 | Schutz CG Rapiti E Vlahov D | 1994 | Drug Alcohol Depend1994，36，2： | 1 |
| 17 | Determinants of the quantity of hepatitis C virus RNA显示文摘 | Thomas DL Astemborski J Vlahov D | 2000 | J Infect Dis2000，181，3： | 1 |
| 18 | The epidemidogy of post-traumatic stress disorder after disasters显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，1： | 1 |
| 19 | Syphilis serologyin human immunodeficiency virus infection : evidence for false-negative fluorescent treponemal testing 显示文摘 | Erbelding EJ Vlahov D NeIson KE | 1997 | Infect Dis1997，176，5： | 1 |
| 20 | The epidemiology of post-traumatic stress disorder after disasters 显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，1： | 1 |
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