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| 1 | Treatment of gastric cancer显示文摘The authors focused on the current surgical treatment of resectable gastric cancer,and significance of periand post-operative chemo or chemoradiation.Gastric cancer is the 4thmost commonly diagnosed cancer and the second leading cause of cancer death worldwide.Surgery remains the only curative therapy,while perioperative and adjuvant chemotherapy,as well as chemoradiation,can improve outcome of resectable gastric cancer with extended lymph node dissection.More than half of radically resected gastric cancer patients relapse locally or with distant metastases,or receive the diagnosis of gastric cancer when tumor is disseminated;therefore,median survival rarely exceeds12 mo,and 5-years survival is less than 10%.Cisplatin and fluoropyrimidine-based chemotherapy,with addition of trastuzumab in human epidermal growth factor receptor 2 positive patients,is the widely used treatment in stageⅣpatients fit for chemotherapy.Recent evidence supports the use of second-line chemotherapy after progression in patients with good performance | Michele Orditura Gennaro Galizia Vincenzo Sforza Valentina Gambardella Alessio Fabozzi Maria Maddalena Laterza Francesca Andreozzi Jole Ventriglia Beatrice Savastano Andrea Mabilia Eva Lieto Fortunato Ciardiello Ferdinando De Vita | 2014 | World Journal of Gastroenterology2014，20，7： | 116 |
| 2 | Incidental gallbladder cancer during laparoscopic cholecystectomy:Managing an unexpected finding显示文摘AIM:To evaluate the impact of incidental gallbladder cancer on surgical experience.METHODS:Between 1998 and 2008 all cases of cholecystectomy at two divisions of general surgery,one university based and one at a public hospital,were retrospectively reviewed.Gallbladder pathology was diagnosed by history,physical examination,and laboratory and imaging studies [ultrasonography and computed tomography(CT)].Patients with gallbladder cancer(GBC) were further analyzed for demographic data,and type of operation,surgical morbidity and mortality,histopathological classification,and survival.Incidental GBC was compared with suspected or preoperatively diagnosed GBC.The primary endpoint was diseasefree survival(DFS).The secondary endpoint was the difference in DFS between patients previously treated with laparoscopic cholecystectomy and those who had oncological resection as first intervention.RESULTS:Nineteen patients(11 women and eight men) were found to have GBC.The male to female ratio was 1:1.4 and the mean age was 68 years(range:45-82 years).Preoperative diagnosis was made in 10 cases,and eight were diagnosed postoperatively.One was suspected intraoperatively and confirmed by frozen sections.The ratio between incidental and nonincidental cases was 9/19.The tumor node metastasis stage was:pTis(1),pT1a(2),pT1b(4),pT2(6),pT3(4),pT4(2);five cases with stageⅠa(T1 a-b);two with stageⅠb(T2 N0);one with stage Ⅱa(T3 N0);six with stage Ⅱb(T1-T3 N1);two with stage Ⅲ(T4 Nx Nx);and one with stage Ⅳ(Tx Nx Mx).Eighty-eight percent of the incidental cases were discovered at an early stage(≤Ⅱ).Preoperative diagnosis of the 19 patients with GBC was:GBC with liver invasion diagnosed by preoperative CT(nine cases),gallbladder abscess perforated into hepatic parenchyma and involving the transversal mesocolon and hepatic hilum(one case),porcelain gallbladder(one case),gallbladder adenoma(one case),and chronic cholelithiasis(eight cases).Every case,except one,with a T1b or more advanced invasion underwent Ⅳb + Ⅴ wedge liver resection and pericholedochic/hepatoduodenal lymphadenectomy.One patient with stage T1b GBC refused further surgery.Cases with Tis and T1a involvement were treated with cholecystectomy alone.One incidental case was diagnosed by intraoperative frozen section and treated with cholecystectomy alone.Six of the nine patients with incidental diagnosis reached 5-year DFS.One patient reached 38 mo survival despite a port-site recurrence 2 years after original surgery.Cases with non incidental diagnosis were more locally advanced and only two patients experienced 5-year DFS.CONCLUSION:Laparoscopic cholecystectomy does not affect survival if implemented properly.Reoperation should have two objectives:R0 resection and clearance of the lymph nodes. | Andrea Cavallaro Gaetano Piccolo Vincenzo Panebianco Emanuele Lo Menzo Massimiliano Berretta Antonio Zanghì Maria Di Vita Alessandro Cappellani | 2012 | World Journal of Gastroenterology2012，18，30： | 33 |
| 3 | Granular cell tumor of stomach: A case report and review of literature显示文摘小粒的房间肿瘤(GCT ) 被 Abrikosoff 在 1926 第一次描述。是一个相对稀罕的瘤可以在皮或软纸巾通常发生在许多地点,而是大多数。在胃肠道的 GCT 的出现是稀罕的,财务近似为 8% 所有肿瘤,最普通的地点在之中是食管,而胃的本地化是很稀罕的。胃的 GCT 能是独居的或,更经常,与另外的胃肠的本地化联系了。尽管 GCT 通常是临床上并且组织学地良性的,一些恶意的案例被报导了。组织学地,这些肿瘤由在紧缩的“巢”和为 S-100 蛋白质的组织化学的染色支持的免疫里处理的多角形、纺锤形的房间组成从 Schwann 房间的建议推导。这个肿瘤的正确外科手术前的诊断能仅仅在 50% 所有病人被做,它总是基于内视镜的活体检视。Laparoscopic 或常规楔切除术代表选择的治疗。在这研究,作者与渗透性的模式与胃的一个独居的小粒的房间肿瘤报导了一个 49 岁的女人的一个案例,成功地与外科的切除术对待。文学的评论也有关恶意的形式在诊断标准上与强调被介绍。 | Rosalia Patti Piero Luigi Almasio Gaetano Di Vita | 2006 | World Journal of Gastroenterology2006，12，21： | 26 |
| 4 | Effects of icosahedral phase formation on the microstructure and mechanical improvement of Mg alloys:A review | D.K. Xu E.H. HanAuthor Vitae | 2012 | Progress in Natural Science:Materials International2012，22，5： | 20 |
| 5 | Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications显示文摘 | Corey E. Tabit William B. Chung Naomi M. Hamburg Joseph A. Vita | 2010 | Reviews in Endocrine and Metabolic Disorders2010，，1： | 19 |
| 6 | Clinical management of advanced gastric cancer: The role of new molecular drugs显示文摘Gastric cancer is the fourth most common malignant neoplasm and the second leading cause of death for cancer in Western countries with more than 20000 new cases yearly diagnosed in the United States.Surgery represents the main approach for this disease but,notwithstanding the advances in surgical techniques,we observed a minimal improvement in terms of overall survival with a significant increasing of relapsing disease rates.Despite the development of new drugs has significantly improved the effectiveness of chemothera-py,the prognosis of patients with unresectable or metastatic gastric adenocarcinoma remains poor.Recently,several molecular target agents have been investigated;in particular,trastuzumab represents the first target molecule showing improvements in overall survival in human epithelial growth factor 2-positive gastric cancer patients.New molecules targeting vascular epithelial growth factor,mammalian target of rapamycin,and anti hepatocyte growth factor-c-Met pathway are also under investigation,with interesting results.Anyway,it seems necessary to select more accurately the population to treat with new agents by the identification of new biomarkers in order to optimize the results.In this paper we review the actual'scenario'of targeted treatments,also focusing on the new agents in development for gastric cancer and gastro-esophageal carcinoma,discussing their efficacy and potential applications in clinical practice. | Ferdinando De Vita Natale Di Martino Alessio Fabozzi Maria Maddalena Laterza Jole Ventriglia Beatrice Savastano Angelica Petrillo Valentina Gambardella Vincenzo Sforza Luigi Marano Annamaria Auricchio Gennaro Galizia Fortunato Ciardiello Michele Orditura | 2014 | World Journal of Gastroenterology2014，20，40： | 12 |
| 7 | 肥胖患者的冠状动脉微血管功能障碍和心血管病风险显示文摘全世界有〉5亿的肥胖人群,其心血管病风险增加的病理生理机制是复杂的,并且可能涉及脂肪细胞相关因子的过量分泌,导致血管氧化应激增加,神经激素活性上调,以及低度全身炎症,可能导致交感神经系统激活增加,血管张力改变,冠状动脉微血管功能障碍(coronary microvascular dysfunction, CMD) 。 | Bajaj NS Osborne MT Gupta A Tavakkoli A Bravo PE Vita T Bibbo CF Hainer J Dorbala S Blankstein R Bhatt DL Di Carli MF Taqueti VR 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 11 |
| 8 | Treatment of esophagogastric junction carcinoma:An unsolved debate显示文摘The incidence of esophagogastric junction adenocarcinoma(AEG) is increasing worldwide. Barrett's esophagus(BE) associated with dysplasia is the main risk factor for the development of cancer. Currently, screening programs to individuate and eradicate BE represent the best way to reduce AEG cancer. Several endoscopic approaches are here discussed. Surgicalstrategies for different types of AEG cancer are now fairly standardized, and multidisciplinary strategies u s i n g c h e m o t h e ra py o r c h e m o ra d i o t h e ra py m ay improve the outcome of these patients. Here we briefly discuss the keypoints, main topics, and critical issues, according to accumulating evidence and taking into account our own experience. | Michele Orditura Gennaro Galizia Eva Lieto Ferdinando De Vita Fortunato Ciardiello | 2015 | World Journal of Gastroenterology2015，21，15： | 10 |
| 9 | Use of biological meshes for abdominal wall reconstruction in highly contaminated fields显示文摘Abdominal wall defects and incisional hernias represent a challenging problem. In particular, when a synthetic mesh is applied to contaminated wounds, its removal is required in 50%-90% of cases. Biosynthetic meshes are the newest tool available to surgeons and they could have a role in ventral hernia repair in a potential-ly contaminated field. We describe the use of a sheet of bovine pericardium graft in the reconstruction of abdominal wall defect in two patients. Bovine pericardium graft was placed in the retrorectus space and secured to the anterior abdominal wall using polypropylene sutures in a tension-free manner. We experienced no evidence of recurrence at 4 and 5 years follow-up. | Andrea Cavallaro Emanuele Lo Menzo Maria Di Vita Antonio Zanghì Vincenzo Cavallaro Pier Francesco Veroux Alessandro Cappellani | 2010 | World Journal of Gastroenterology2010，16，15： | 9 |
| 10 | 肠壁Crohn病:动态增强MR成像与组织学血管生成、炎症的相关性——初步研究显示文摘目的采用动态增强MRI评估Corohn病的肠壁灌注动力学改变,并与炎症、血管生成的组织病理学指标进行相关分析。方法本研究经伦敦大学医院伦理委员会批准.所有参加者均知情同意。2006年7月-2007年12月,连续11例行选择性小肠切除的Crohn病人(女性8例,男性3例:年龄16.4-66.6岁,平均39.5岁)纳入本研究。记录Harvev—Bradshaw指数、C反应蛋白水平和疾病慢性史(chronicity)。术前对拟切除的肠管进行动态增强MRI检查,计算受累肠段的增强斜率、达峰时间、强化率、通透系数、 | S.A.Taylor S.Punwani M.Rodriguez-Justo A.Bainbridge R.Greenhalgh E.De Vita 龙淼淼 | 2009 | 国际医学放射学杂志2009，32，4： | 6 |
| 11 | Splenic lymphangiomatosis showing rapid growth during lactation:A case report显示文摘Splenic lymphangiomatosis is a very rare condition that,from 1990 to date,has been described only nine times.In the present report,we describe the first case of splenic lymphangiomatosis with rapid growth during lactation in a 35-year-old woman.We also underline the difficultly in making an accurate preoperative diagnosis,despite more modern imaging techniques.Total splenectomy was considered to be the treatment needed,both to make a definitive diagnosis and to exclude the presence of malignancy. | Rosalia Patti Emilio Iannitto Gaetano Di Vita | 2010 | World Journal of Gastroenterology2010，16，9： | 5 |
| 12 | Fast Algorithm for Nonsubsampled Contourlet Transform显示文摘多尺度的几何分析(MGA ) 为图象处理作为有效策略被认出了。作为 MGA 的分离工具之一, nonsubsampled contourlet 变换(NSCT ) 广泛地被使用了图象降噪,图象熔化,图象改进,特征抽取等等。然而,处理表演由于它的高冗余性被限制,并且导致集中的计算效率。因此,它的快算法在实践被需要。在这份报纸,我们采用一个优化方向性的过滤器银行(DFB ) 并且把它嵌进 NSCT 当使重建的表演的损失细微时,显著地加速计算速度。试验性的结果证明重建的图象质量能满足人的视觉系统。而且,改进 NSCT 有速度关于若干次比传统的的。图象降噪上的试验性的结果也验证建议方法的可行性和效率。 | Chun-Man YAN Bao-Long GUO Meng YI | 2014 | 自动化学报2014，40，4： | 5 |
| 13 | Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients显示文摘 | Noyan Gokce Joseph A. Vita Marie McDonnell Armour R. Forse Nawfal Istfan Maria Stoeckl Izabella Lipinska John F. Keaney Caroline M. Apovian | 2005 | The American Journal of Cardiology2005，，2： | 4 |
| 14 | Is complete mesocolic excision with central vascular ligation safe and effective in the surgical treatment of right-sided colon cancers? A prospective study显示文摘 | Gennaro Galizia Eva Lieto Ferdinando Vita Francesca Ferraraccio Anna Zamboli Andrea Mabilia Annamaria Auricchio Paolo Castellano Vincenzo Napolitano Michele Orditura | 2014 | International Journal of Colorectal Disease2014，，1： | 3 |
| 15 | Minimally invasive surgical approach to pancreatic malignancies显示文摘Pancreatic surgery for malignancy is recognized as challenging for the surgeons and risky for the patientsdue to consistent perioperative morbidity and mortality. Furthermore, the oncological long-term results are largely disappointing, even for those patients who experience an uneventfully hospital stay. Nevertheless, surgery still remains the cornerstone of a multidisciplinary treatment for pancreatic cancer. In order to maximize the benefits of surgery, the advent of both laparoscopy and robotics has led many surgeons to treat pancreatic cancers with these new methodologies. The reduction of postoperative complications, length of hospital stay and pain, together with a shorter interval between surgery and the beginning of adjuvant chemotherapy, represent the potential advantages over conventional surgery. Lastly, a better cosmetic result, although not crucial in any cancerous patient, could also play a role by improving overall well-being and patient self-perception. The laparoscopic approach to pancreatic surgery is, however, difficult in inexperienced hands and requires a dedicated training in both advanced laparoscopy and pancreatic surgery. The recent large diffusion of the da Vinci® robotic platform seems to facilitate many of the technical maneuvers, such as anastomotic biliary and pancreatic reconstructions, accurate lymphadenectomy, and vascular sutures. The two main pancreatic operations, distal pancreatectomy and pancreaticoduodenectomy, are approachable by a minimally invasive path, but more limited interventions such as enucleation are also feasible. Nevertheless, a word of caution should be taken into account when considering the increasing costs of these newest technologies because the main concerns regarding these are the maintenance of all oncological standards and the lack of long-term follow-up. The purpose of this review is to examine the evidence for the use of minimally invasive surgery in pancreatic cancer(and less aggressive tumors), with particular attention to the oncological results and widespread reproducibility of each technique. | Lapo Bencini Mario Annecchiarico Marco Farsi Ilenia Bartolini Vita Mirasolo Francesco Guerra Andrea Coratti | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 3 |
| 16 | Carbon and Nickel Oxide/Carbon Composites as Electrodes for Supercapacitors显示文摘The carbon and nickel oxide/carbon composite electrodes were prepared by plasma jet and magnetron sputtering techniques.The investigations were performed to evaluate the influence of the Ar/C 2 H 2 ratio on the specific capacitance values of carbon and NiO/carbon electrodes.The obtained electrodes were investigated by scanning electron microscopy,Raman scattering spectroscopy(RS),and X-ray diffraction techniques.The surface of the carbon electrodes became less porous and more homogenous with increasing Ar/C 2 H 2.The RS results indicated that the fraction of the sp 2 carbon sites increased with increasing Ar/C 2 H 2 ratio.The increase of the Ar/C 2 H 2 ratio increased the capacitance values from 0.73 up to 3.6 F/g.Meanwhile,after the deposition of the nickel oxide on the carbon,the capacitance increased ten and more times and varied in the range of 7.6-86.1 F/g. | Liutauras Marcinauskas Zydrūnas Kavaliauskas Vitas Valinius | 2012 | Journal of Materials Science & Technology2012，28，10： | 3 |
| 17 | 磁共振成像T2客观定量测量等同足月早产儿大脑白质信号强度的研究显示文摘目的对比大脑白质(WM)定量的B值测定和常规T2WMRI的定性评价,评价早产儿大脑WMT2和局域特异表观扩散系数(ADC)的关系,检查早产儿等同足月时WMT2局部变化。材料与方法研究经本地医学伦理委员会批准并获取每例婴儿的知情同意通知。小于32孕周的62名早产儿和7名作为对照的正常新生儿在1.5TMR设备上进行了扫描,获取T2加权的快速自旋回波序列MR影像、T2数据及扩散加权MR影像。 | C.F.Hagmann E.De Vita A.Bainbridge R.Gunny A.B.Kapetanakis W.K.Chong 高莉 | 2009 | 国际医学放射学杂志2009，32，5： | 3 |
| 18 | Peritonitis from Perforated Appendicitis: Stress Response after Laparoscopic or Open Treatment显示文摘 | Schietroma Mario Piccione Federica Carlei Francesco Clementi Marco Bianchi Zuleyka de Vita Fabiola Amicucci Gianfranco | 2012 | EN2012，，5： | 2 |
| 19 | Occult hepatitis B virus in liver tissue of individuals without hepatic disease显示文摘 | Giovanni Raimondo Giuseppe Navarra Stefania Mondello Lucy Costantino Guido Colloredo Eugenio Cucinotta Gaetano Di Vita Claudio Scisca Giovanni Squadrito Teresa Pollicino | 2008 | Journal of Hepatology2008，，5： | 2 |
| 20 | Safety and efficacy of sorafenib in patients with advanced hepatocellularcarcinoma and Child-Pugh A or B cirrhosis显示文摘 | Alessandro Federico Michele Orditura Gaetano Cotticelli Ilario De Sio Marco Romano Antonietta Gravina Marcello Dallio Alessio Fabozzi Fortunato Ciardiello Carmela Loguercio Ferdinando De Vita | 2015 | Oncology Letters2015，，4： | 2 |
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