|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Implication of the Hedgehog pathway in hepatocellular carcinoma显示文摘The prognosis for patients who are diagnosed with advanced stage hepatocellular carcinoma(HCC)is poor because there are few treatment options.Recent research has focused on the identification of novel molecular entities that can be targeted to inhibit oncogenic signals that are involved in the carcinogenesis,proliferation and progression of HCC.Among all of the pathways that are involved in the development of HCC,Hedgehog(HH)signalling has demonstrated a substantial role in hepatocarcinogenesis and HCC progression.HH plays a physiological role in embryogenesis,through the induction of the differentiation of hepatocytes from endodermal progenitors.The re-activation of the HH pathway in chronic damaged liver is a mechanism of fibrotic degeneration and is implicated in various stages of HCC development.HH activation sustains the subpopulation of immature liver epithelial cells that are involved in the pathogenesis of cirrhosis and HCC,and HH itself is a mediator of the alcohol-derived malignant transformation of liver cells.High levels of expression of HH protein markers in liver tumour tissues are correlated with aggressive histological and biological features and a poor clinical outcome.In vitro and in vivo inhibition models of the HH pathway confirm that HH is essential in maintaining tumour growth,metastasis and a mesenchymal phenotype. | Carminia Maria Della Corte Giuseppe Viscardi Federica Papaccio Giovanna Esposito Giulia Martini Davide Ciardiello Erika Martinelli Fortunato Ciardiello Floriana Morgillo | 2017 | World Journal of Gastroenterology2017，23，24： | 10 |
| 2 | Insight into the interaction of inhaled corticosteroids with human serum albumin: A spectroscopic-based study显示文摘It is well known that the safety and efficacy profile of an inhaled cortocosteroid(ICS) is influenced by the pharmacokinetic properties and associated pharmacodynamic effects of the drug. Freely circulating,protein unbound, and active ICS can cause systemic adverse effects. Therefore, a detailed investigation of drug-protein interaction could be of great interest to understand the pharmacokinetic behaviour of corticosteroids and for the design of new analogues with effective pharmacological properties. In the present work, the interaction between some corticosteroids and human serum albumin(HSA) has been studied by spectroscopic approaches. UV–Vis spectroscopy confirmed that all the investigated corticosteroids can bind to HSA forming a protein-drug complex. The intrinsic fluorescence of HSA was quenched by all the investigated drugs, which was rationalized in terms of a static quenching mechanism. The thermodynamic parameters determined by the Van't Hoff analysis of the binding constants(negative ΔH and ΔS values) clearly indicate thathydrogen bonds and van der Waals forces play a major role in the binding process between albumin and betamethasone, flunisolide and prednisolone, while hydrophobic forces may play a major role in stabilizing albumin-triamcinolone complexes. | Carlotta Pontremoli Nadia Barbero Guido Viscardi Sonja Visentin | 2018 | Journal of Pharmaceutical Analysis2018，8，1： | 2 |
| 3 | Perinatal inflammation and lung injury 显示文摘 | Viscardi RM | 2011 | Semin Fetal Neonatal Med2011，18，2： | 1 |
| 4 | Synthesis and surface and antimicrobial prop- erties of novel cationic surfactants显示文摘 | Viscardi G | 2000 | J Org Chem2000，65，： | 1 |
| 5 | Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid com- partments are associated with adverse pulmonary and neurologic out-comes in preterm infants 显示文摘 | Viscardi RM Muhumuza CK Rodriguez A | 2004 | Pediatr Res2004，55，6： | 1 |
| 6 | Effects of hypothennia and hyperthermia on cytokine production by cultured, human mononuclear phagocytes from adults and new borns显示文摘 | Fairchild KD Viscardi RM Hester L | 2000 | J Interferon Cytokine Res2000，20，12： | 1 |
| 7 | Disordered pulmonary myofibroblast distribution and elastin expression in preterm infants with Ureaplasma urealyticum pneumonitis显示文摘 | Viscardi R Manimtinl W He JR | 2006 | Pediatr Dev Pathol2006，9，2： | 1 |
| 8 | Changes in the chemical composition of basil caused by different drying procedures显示文摘 | DICESARE L F FORNI E VISCARDI D | 2003 | Journal of Agricultural and Food Chemistry2003，，51： | 1 |
| 9 | Perinatal inflammation and lung injury 显示文摘 | Viscardi RM | 2012 | Semin Fetal Neonatal Med2012，17，1： | 1 |
| 10 | Pefinatal inflammation and lung injury 显示文摘 | Viscardi RM | 2012 | Semin Fetal Neonatal Med2012，17，1： | 1 |
| 11 | Perinatal inflammation and lung injury 显示文摘 | Viscardi RM | 2012 | Semin Fetal Neonatal Med2012，17，1： | 1 |
| 12 | Fluorescent nanotools for biotechnology: Disclosure of the molecular features ruling the brightness of dye-silica nanoparticles 显示文摘 | Alberto G Caputo G Viscardi G | 2011 | Current Opinion in Biotechnology2011，22，1： | 1 |
| 13 | Disordered pulmonary myofibroblast distribution and elastin ex- pression in preterm infants with Ureaplasma urealyticum pneumonitis显示文摘 | Viscardi R Manimtim W He JR | 2006 | Pediatr Dev Pathol2006，9，2： | 1 |
| 14 | Adult respiratory distress syndrome in full-term newborns显示文摘 | FAIX RG VISCARDI RM DIPIETRO MA | 1989 | Pediatrics1989，83，6： | 1 |
| 15 | Ureaplasma species:role in neonatal morbidities and outcomes显示文摘 | VISCARDI R M | 2014 | Arch Dis Child Fetal Neonatal Ed2014，99，1： | 1 |
| 16 | Gemini pyridinium surfactants: synthesis and conductometrie study of a novel class of amphiphiles 显示文摘 | QUAGLIOTYO P VISCARDI G BAROLO C | 2003 | The Journal of Organic Chemistry2003，68，： | 1 |
| 17 | Ureaplasma urealyticum respiratory tract colonization is associated with an increase in interleukin 1-beta and tumour necrosis factor alpha relative to interleukin 6 in tracheal aspirates of preterm infants显示文摘 | Patterson AM Taciak V Lovchik J Fox RE Campbell AB Viscardi RM | 1998 | Pediatr Infect Dis J1998，17，： | 1 |
| 18 | Lung pathology in premature infants with Ureaplasma urealyticum infection 显示文摘 | Viscardi R M Manimtim W M Sun C C | 2002 | Pediatr Dev Pathol2002，5，2： | 1 |
| 19 | In- 71ammatory markers in intraulerine and fetal blood and ce-rebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants 显示文摘 | Viscardi R M Muhurmuza C K Rodrignez A | 2004 | Pediatr Res2004，55，： | 1 |
| 20 | Effects of hypothermia and hyperthermia on cytokine production by cultured human mononudear phagocytes from adults and newborns显示文摘 | Fairchild K D Viscardi R M Hester L | 2000 | J Interferon Cytokine Res2000，20，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员