|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of Lepidium meyenii (maca) roots on spermatogenesis of male rats显示文摘Aim: To determine the effect of oral administration of an aqueous extract from the roots of Lepidium meyenii (maca)on spermatogenesis in adult male rats. Methods: Male rats received an aqueous extract of the root (66.7 mg in one mL) twice a day for 14 consecutive days. Results: Treatment with Lepidium meyenii resulted in an increase in the weights of testis and epididymis but not the seminal vesicle weight. The length and frequency of stages IX-XIV seminiferous tubules, where mitosis occurred, were increased and stages Ⅰ-Ⅵ were reduced in rats treated with Lepidium meyenii. Conclusion: The Lepidium meyenii root invigorates spermatogenesis in male rats by acting on its initial stages (IX-XIV). | Gustavo F.Gonzales Ana Ruiz Carla Gonzales León Villegas Amanda Cordova | 2001 | Asian Journal of Andrology2001，3，3： | 22 |
| 2 | Effect of two different extracts of red maca in male rats with testosterone-induced prostatic hyperplasia显示文摘瞄准:在更男的 ats 决定红 maca 的二篇不同摘录的效果。方法:Prostatic 增生与睾丸激素 enanthate (TE ) 在雄的老鼠被导致。Thestudy 包括了六个组:一个控制组(组 1 ),与 TE (组 2 )对待的一个组,与 TE 对待的二个组和红 maca 的水的摘录(组织 3 和 4 ),一个组对待红 maca (组 5 )的 withhydroalcoholic 摘录,一个组与 finasteride 对待( 0.1 mg , group6 )。在沸腾的时间的长度上的水的摘录依赖者的差别,是否为 2 个 or3 小时,为组, 3 和 4 被估计。红 maca 的摘录包含了 0.1 mg ofbenzylglucosinolate。此后,在红 maca 摘录的 benzylglucosinolates (0.02-0.08 mg ) 的不同剂量的剂量反应效果被估计。结果:前列腺重量在与红 maca 的水的摘录在沸腾的 2 和 3 个小时以后准备了的 freeze-dried 对待的老鼠是类似的。红 maca 的 Freeze-dried 水的摘录,红 maca 和 finasteride 的水疗院酒鬼摘录与职业人员静电干扰增生在老鼠减少了前列腺重量。没有差别在从水的摘录或红 maca 的水疗院酒鬼摘录获得的数据之间被观察。前列腺重量的剂量依赖者减小随红 macaextracts 的 benzylglucosinolates 的剂量的增加被观察。结论:现在的学习在 prostatichyperplasia 被 TE 在导致了的雄的老鼠给那个水疗院酒鬼或红 macacontaining 的水的摘录看了 benzylglucosinolate 罐头还原剂前列腺尺寸的 0.1 mg。 | Gustavo F. Gonzales Vanessa Vasquez Daniella Rodriguez Carmen Maldonado Juliet Mormontoy Jimmy Portella Monica Pajuelo León Villegas Manuel Gasco | 2007 | Asian Journal of Andrology2007，9，2： | 14 |
| 3 | Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease显示文摘Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018.A large amount of evidence supports the amyloid cascade hypothesis,which states that amyloid-beta accumulation triggers tau hyperphosphorylation and aggregation in form of neurofibrillary tangles,and these aggregates lead to inflammation,synaptic impairment,neuronal loss,and thus to cognitive decline and behavioral abnormalities.The poor correlation found between cognitive decline and amyloid plaques,have led the scientific community to question whether amyloid-beta accumulation is actually triggering neurodegeneration in Alzheimer’s disease.The occurrence of tau neurofibrillary tangles better correlates to neuronal loss and clinical symptoms and,although amyloid-beta may initiate the cascade of events,tau impairment is likely the effector molecule of neurodegeneration.Recently,it has been shown that amyloid-beta and tau cooperatively work to impair transcription of genes involved in synaptic function and,more importantly,that downregulation of tau partially reverses transcriptional perturbations.Despite mounting evidence points to an interplay between amyloid-beta and tau,some factors could independently affect both pathologies.Thus,the dual pathway hypothesis,which states that there are common upstream triggers causing both amyloid-beta and tau abnormalities has been proposed.Among others,the immune system seems to be strongly involved in amyloid-beta and tau pathologies.Other factors,as the apolipoprotein Eε4 isoform has been suggested to act as a link between amyloid-beta and tau hyperphosphorylation.Interestingly,amyloid-beta-immunotherapy reduces not only amyloid-beta but also tau levels in animal models and in clinical trials.Likewise,it has been shown that tau-immunotherapy also reduces amyloid-beta levels.Thus,even though amyloid-beta immunotherapy is more advanced than tau-immunotherapy,combined amyloid-beta and tau-directed therapies at early stages of the disease have recently been proposed as a strategy to stop the progression of Alzheimer’s disease. | Alejandro R.Roda Gabriel Serra-Mir Laia Montoliu-Gaya Lidia Tiessler Sandra Villegas | 2022 | Neural Regeneration Research2022，17，8： | 13 |
| 4 | Conventional digital cameras as a tool for assessing leaf area index and biomass for cereal breeding显示文摘Affordable and easy-to-use methods for assessing biomass and leaf area index(LAI) would be of interest in most breeding programs. Here, we describe the evaluation of a protocol for photographic sampling and image analysis aimed at providing low-labor yet robust indicators of biomass and LAI. In this trial, two genotypes of triticale, two of bread wheat, and four of tritordeum were studied. At six dates during the growing cycle, biomass and LAI were measured destructively, and digital photography was taken on the same dates. Several vegetation indices were calculated from each image. The results showed that repeatable and consistent values of the indices were obtained in consecutive photographic samplings on the same plots. The photographic indices were highly correlated with the destructive measurements, though the magnitude of the correlation was lower after anthesis. This work shows that photographic assess-ment of biomass and LAI can be fast, affordable, have good repeatability, and can be used under bright and overcast skies. A practical vegetation index derived from pictures is the fraction of green pixels over the total pixels of the image, and as it shows good correlations with all biomass variables, is the most robust to lighting conditions and has easy interpretation. | Jaume Casadesús Dolors Villegas | 2014 | Journal of Integrative Plant Biology2014，56，1： | 7 |
| 5 | Effect of alcoholic extract of Lepidium meyenii (Maca) on testicular function in male rats显示文摘Aim: To evaluate the effect of the alcoholic extract of Lepidium meyenii (Maca) on the spermatogenesisin male rats. Methods: In Holtzman rats, Maca alcoholic extract (5 %) was given by oral route at doses of 48 mg/day or 96 mg/day for 7 days, 14 days and 21 days. Testicular function was assessed by measurements of lengths of different stages of seminiferous epithelia and by epididymal sperm count. Results: Ethanolic extract of Maca increased the length of stages IX-XI of seminiferous epithelium at treatment day 7, day 14 and day 21. Progression of spermatogenesis was evident only after day 21 when lengths of stages XII-XIV of seminiferous epithelium were increased; at day 7 and day 14, no important change in spermatogenesis was observed. Epididymal sperm count was increased with 48 mg/day at all times. With 96 mg/day an increase in sperm count was observed at day 7, but it was reduced at day 14 and day 21 of treatment. Serum testosterone levels were not affected. Conclusion: The alcoholic extract of Maca activates onset ant progression of spermatogenesis at 48 mg/day or 96 mg/day in rats. | Gustavo F. Gonzales Julio Rubio Arturo Chung Manuel Gasco León Villegas | 2003 | Asian Journal of Andrology2003，5，4： | 6 |
| 6 | Prevalence and dietetic management of mild gastrointestinal disorders in milk-fed infants显示文摘AIM: To assess the prevalence of mild gastrointestinal disorders in milk-fed infants in paediatric practice, and to evaluate the effectiveness and satisfaction with dietetic treatment.METHODS: A cross-sectional epidemiological study was first carried out. A total of 285 paediatricians included 3487 children seen during a period of one week. In a second phase an observational, prospective and multicentre study was conducted and 2069 milk-fed infants with mild gastrointestinal disorders (colic, constipation, regurgitation and diarrhoea) were included. There was a baseline visit (start of treatment) and a final visit four weeks later. The effectiveness of the various Novalac formulas, as well as the satisfaction of the parents/tutors and paediatricians with the dietetic treatment were assessed at the final visit.RESULTS: The prevalence of mild gastrointestinal disorders was 27.8% of all paediatrician consultations (9.2%, 7.8%, 6.1% and 4.6% in relation to colic, constipation, regurgitation and diarrhoea, respectively). The several Novalac adapted milk formulas resolved 88.4% of the mild gastrointestinal disorders. Depending on the type of disorder, differences in response rate were observed. The highest effectiveness was recorded with respect to diarrhoea (92.6%), followed by constipation (91.6%), colic (87.6%) and regurgitation (81%). Overall, 91% of the paediatricians and 88.8% of the parents/tutors were satisfied or very satisfied with the Novalac adapted milk formulas.CONCLUSION: Mild gastrointestinal disorders show a high prevalence in paediatric practice. The Novalac adapted milk formulas have been shown to be effective in treating mild gastrointestinal disorders in milk-fed infants in the context of routine clinical practice. | D Infante Pina X Badia Llach B Ario-Armengol V Villegas Iglesias | 2008 | World Journal of Gastroenterology2008，14，2： | 5 |
| 7 | 历史分析与比较政治显示文摘本文讨论了比较政治学中历史研究的主要分析方法。第一类是因果分析法,包括横截面分析法和样本内分析法。第二类是时序分析法,包括对路径依赖和发展顺序的分析。本文认为,历史分析与众不同的分析方法使它成为比较政治研究中有力的分析工具。 | James Mahoney Celso M. Villegas | 2008 | 浙江社会科学2008，，3： | 4 |
| 8 | Sphincter of oddi manometry in healthy volunteers显示文摘 | Dr. Moises Guelrud MD FACG Sonia Mendoza MD Guillermo Rossiter MD Maria I. Villegas MD | 1990 | Digestive Diseases and Sciences1990，，1： | 2 |
| 9 | Cloud federation in a layered service model显示文摘 | David Villegas Norman Bobroff Ivan Rodero Javier Delgado Yanbin Liu Aditya Devarakonda Liana Fong S. Masoud Sadjadi Manish Parashar | 2012 | Journal of Computer and System Sciences2012，，5： | 2 |
| 10 | 拉·维莱特公园显示文摘1983年,伯纳德·屈米建筑师事务所从470支团队里脱颖而出,赢得了巴黎拉。维莱特公园国际设计竞赛。该项目同新法国国家图书馆、卢浮宫金字塔、拉德芳斯新凯旋门和阿拉伯世界研究中心等项目一样,是当时法国政府主持的几大工程之一。那次设计竞赛的目标是表达时代愿景,推动项目所处的巴黎关键区域未来经济和文化的发展。 | bernard tschumi luca merlini alexandra villegas luca pagnamenta jon olsen jean-franCois erhel ursula kurz christian biecher marie-line luquet neil porter steve mcadam jean-pierre nourry didier pasquier renzo bader | 2016 | 城市环境设计2016，0，1： | 2 |
| 11 | HLA B27 as Predisposition Factor to Suffer Age Related Macular Degeneration显示文摘研究是否特定的等位基因 HLA 一级(HLA -- A 和 HLA-B ) 并且班 II (HLA 医生) 是风险因素因为年龄的 exudative 类型的发展联系了有斑点的退化(ARMD ) , HLA 抗原与 ARMD 在正常、影响的眼睛两个都被表示。我们设计了未来的控制盒子的研究。我们与主要经典或秘密的 choroidal neovascularization 招募了 75 个病人,对 ARMD 第二等,并且与光力学的治疗对待。超过 55 岁的 250 个病人,没有 ophthalmologic 病理,为分析平淡的检查去了医院的人,被用作控制。数据的分析显示出二个组之间的重要差别。等位基因 HLA-B27 与 ARMD 断然相关(p < 0.0113 ) 。然而,我们没发现等位基因否定地联系了。因此 HLA-B27 是等位基因预先安排承受 ARMD。 | Enrique Villegas Becerril Rafael Gonzalez Fernandez Luis Perula Torres Manuel Santos Lacomba Jose Maria Gallardo Galera | 2009 | Cellular & Molecular Immunology2009，6，4： | 2 |
| 12 | Dissemination of Acinetobacter baumannii clones with OXA-23 Carbapenemase in Colombian hospitals显示文摘 | Villegas MV Kattan JN Correa A | 2007 | Antimicrob Agents Chemother2007，51，6： | 1 |
| 13 | Molecular characterization of brazilian infectious bursal disease virus 显示文摘 | Ikuta N Attrache JEL Villegas P | 2001 | Avian Disease2001，45，： | 1 |
| 14 | Diabetes mellitus following cisplatin treatment显示文摘 | Nan DN Femandez-Ayala M Vega Villegas ME | 2003 | Acha Oncol2003，42，1： | 1 |
| 15 | Dissemination of Acinetobacter baumannii clones with OXA-23 carbapenemase in Colombian Hospitals显示文摘 | Villegas MV Kattan JN Correa A | 2007 | Antimicrob Agents Chemother2007，51，6： | 1 |
| 16 | Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential显示文摘 | FAN H VILLEGAS C WRIGHT J A | 1996 | Proc Natl Acad Sci USA1996，93，14： | 1 |
| 17 | Synthesis and characterization of TM-MCM-48 (TM = Mn,V,Cr) and their catalytic activity in the oxidation of styrene 显示文摘 | GóMEZ S GARCES L J VILLEGAS J | 2005 | J Catal2005，233，1： | 1 |
| 18 | A new flavonoid derivative,dosmalfate,attenuates the development of dextran sulphate sodium induced colitis in mice显示文摘 | Villegas I Lastra C A Orjales A | 2003 | Int Immunopharmacol2003，3，1314： | 1 |
| 19 | Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implica- tions显示文摘 | de la Lastra CA Villegas I | 2007 | Biochem Soc Trans2007，35，5： | 1 |
| 20 | Left atrial isomerism detected in fetal life显示文摘 | Phoon CK Villegas MD Ursell PC | | 0，，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员