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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 3 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 4 | Immobilization of phenol in cement-based solidified/stabilized hazardous wastes using regenerated activated carbon: Leaching Studies显示文摘 | VIKRAM M HASSAN A HONG S | 1999 | J Hazard Mater1999，0，： | 1 |
| 5 | The Physics and Technology of Gallium Antimonide: An Emerging Optoelectronic Material显示文摘 | Dutta P S Bhat H L Vikram K | 1997 | J Appl Phys1997，81，： | 1 |
| 6 | Foveal structure defined by spectral domain optical coherencetomography correlates with visual function after macular holesurgeiy显示文摘 | Kakarala V Ravi K Shailesh K Gupta B Vikram S Sandeep G | 2010 | Eur J Ophthalmol2010，20，3： | 1 |
| 7 | Bioethanol production from rice straw: An overview显示文摘 | Binod P Sindhu R Singhania RR Vikram S Devi L Nagalakshmi S Kurien N Sukumaran RK Pandey A | 2010 | Bioresource Technology2010，101，13： | 1 |
| 8 | Potential of Laceyella saccharistrain B42 crude xylanase in biobleaching of kraft pulp显示文摘 | Vikram S Vinod C P Sanjeev A | 2013 | Afri-can Journal of Biotechnology2013，12，6： | 1 |
| 9 | Thrombin inhibition by argatro- ban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats 显示文摘 | Takashi S Vikram J Robert A | 2009 | Stroke2009，40，： | 1 |
| 10 | Thrombin inhibition by argatroban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats 显示文摘 | Takashi S Vikram J Robert A | 2009 | Stroke2009，40，4： | 1 |
| 11 | A Novel Neuropro-tectant Granulocyte-Colony Stimulating Factor显示文摘 | Ihsan S Julian C Vikram J | 2001 | Stroke2001，37，4： | 1 |
| 12 | Spatial correlation and MIMO capacity of uniform rectangular dipole arrays显示文摘 | Raj J S K Prabu A S Vikram N | 2008 | IEEE Antennas and Wireless Propagation Letters2008，，7： | 1 |
| 13 | Safety and effcacy of bilateral simultaneous tubeless percutaneous nephrolithtomy显示文摘 | Hemendra N Vikram B Sunil S at al | 2005 | Urology2005，66，： | 1 |
| 14 | Sonography of the Scrotum显示文摘 | VIKRAM S DOGRA M D RONALD H | 2003 | Radiology2003，227，： | 1 |
| 15 | Optimal rate allocation for energy-efficient multipath routing in wireless ad hoe networks显示文摘 | VIKRAM S CARLA-FABIANA C PAVAN S | 2004 | IEEE Transactions on Wireless Communications2004，3，3： | 1 |
| 16 | The role of lipids in the development of diabetic microvascular complications:implications for therapy显示文摘 | Misra A Kumar S Kishore Vikram | 2003 | Am J Cardiovasc Drugs2003，3，5： | 1 |
| 17 | Thrombin inhibition by argatroban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats显示文摘 | Takashi S Vikram J Robert A | 2009 | Stroke2009，40，4： | 1 |
| 18 | Damage identification in com- posite materials using ultrasonic based Lamb wave method显示文摘 | Ben B S Ben B A Vikram K A | 2013 | Measuremen2013，46，2： | 1 |
| 19 | Second harmonic operation at 460GHz and broadband continuous frequency tuning of a gyrotron oscillator 显示文摘 | Melissa K Homstein Vikram S Bajaj RobertG Griffin | 2005 | IEEE Trans Electron Devices2005，52，5： | 1 |
| 20 | Effect of Different Supplementary Cementitious Material on the Microstructure and its Resistance Against Chloride Penetration of Concrete显示文摘 | Vinay S N Vikram Y T | 2003 | ECI Conference on Advanced Materials for Construction of Bridges Buildings and Other Structures Ⅲ2003，2003，5： | 1 |
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