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| 1 | Anti-inflammatory properties of the short-chain fatty acids acetate and propionate:A study with relevance to inflammatory bowel disease显示文摘AIM: To compare the anti-inflammatory properties of butyrate with two other SCFAs,namely acetate and propionate,which have less well-documented effects on inflammation. METHODS: The effect of SCFAs on cytokine release from human neutrophils was studied with ELISA. SCFA-dependent modulation of NF-κB reporter activity was assessed in the human colon adenocarcinoma cell line,Colo320DM. Finally,the effect of SCFAs on gene expression and cytokine release,measured with RT-PCR and ELISA,respectively,was studied in mouse colon organ cultures established from colitic mice. RESULTS: Acetate,propionate and butyrate at 30 mmol/L decreased LPS-stimulated TNFα release from neutrophils,without affecting IL-8 protein release. All SCFAs dose dependently inhibited NF-κB reporter activity in Colo320DM cells. Propionate dose-dependently suppressed IL-6 mRNA and protein release from colon organ cultures and comparative studies revealed that propionate and butyrate at 30 mmol/L caused a strong inhibition of immune-related gene expression,whereas acetate was less effective. A similar inhibition was achieved with the proteasome inhibitor MG-132,but not the p38 MAPK inhibitor SB203580. All SCFAs decreased IL-6 protein release from organ cultures. CONCLUSION: In the present study propionate and butyrate were equipotent,whereas acetate was less effective,at suppressing NF-κB reporter activity,immune-related gene expression and cytokine release in vitro. Our findings suggest that propionate and acetate,in addition to butyrate,could be useful in the treatment of inflammatory disorders,including IBD. | Sofia Tedelind Fredrik Westberg Martin Kjerrulf Alexander Vidal | 2007 | World Journal of Gastroenterology2007，13，20： | 81 |
| 2 | Study of the production of Λ_b^0 band ~0 hadrons in pp collisions and first measurement of the Λ_b^0→J/ψpK^- branching fraction显示文摘The product of the A_b^0(B^0) differential production cross-section and the branching fraction of the decay A_b^0→J/ψpK^-(B^0→J/ψK~*(892)~0) is measured as a function of the beauty hadron transverse momentum,p_T,and rapidity,y.The kinematic region of the measurements is p_T <20 GeV/c and 2.0 | O.Kochebina M.Kolpin I.Komarov R.F.Koopman P.Koppenburg M.Kozeiha L.Kravchuk K.Kreplin M.Kreps G.Krocker P.Krokovny F.Kruse W.Krzemien W.Kucewicz M.Kucharczyk V.Kudryavtsev A.K.Kuonen K.Kurek T.Kvaratskheliya D.Lacarrere G.Lafferty A.Lai D.Lambert G.Lanffanchi C.Langenbruch B.Langhans T.Latham C.Lazzeroni R.Le Gac J.van Leerdam J.-P.Lees R.Lefevre A.Leflat J.Lefrancois E.Lemos Cid O.Leroy T.Lesiak B.Leverington Y.Li T.Likhomanenko M.Liles R.Lindner C.Linn F.Lionetto B.Liu X.Liu D.Loh I.Longstaff J.H.Lopes D.Lucchesi M.Lucio Martinez H.Luo A.Lupato E.Luppi O.Lupton A.Lusiani F.Machefert F.Maciuc O.Maev K.Maguire S.Malde A.Malinin G.Manca G.Mancinelli P.Manning A.Mapelli J.Maratas J.F.Marchand U.Marconi C.Marin Benito P.Marino J.Marks G.Martellottil M.Martin M.Martinelli D.Martinez Santos F.Martinez Vidal D.Martins Tostes A.Massafferri R.Matev A.Mathad Z.Mathe C.Matteuzzi A.Mauri B.Maurin A.Mazurov M.McCann J.McCarthy A.McNab R.McNulty B.Meadows F.Meier M.Meissner D.Melnychuk M.Merk E Michielin D.A.Milanes M.-N.Minard D.S.Mitzel J.Molina Rodrigue I.A.Monroy S.Monteil M.Morandin P.Morawski A.Morda M.J.Morello J.Moron A.B.Morris R.Mountain F.Muheim D.Miiller J.Muller K.Muller V.Muller M.Mussini B.Muster P.Naik T.Nakada R.Nandakumar A.Nandi I.Nasteva M.Needham N.Neri S.Neubert N.Neufeld M.Neuner A.D.Nguyen T.D.Nguyen C.Nguyen-Mau V.Niess R.Niet N.Nikitin T.Nikodem D.Ninci A.Novoselov D.P.O'Hanlon A.Oblakowska-Mucha V.Obraztsov S.Ogilvy O.Okhrimenko R.Oldeman C.J.G.Onderwater B.Osorio Rodrigues J.M.Otalora Goicochea A.Otto P.Owen A.Oyanguren A.Palano F.Palombo M.Palutan J.Panman A.Papanestis M.Pappagallo L.L.Pappalardo C.Pappenheimer C.Parkes G.Passaleva G.D.Patel M.Patel C.Patrignani A.Pearce A.Pellegrino G.Penso M.Pepe Altarelli S.Perazzini P.Perret L.Pescatore K.Petridis A.Petrolini M.Petruzzo E.Picatoste Olloqui B.Pietrzyk T:.Pilar D.Pinci A.Pistone A.Piucci S.Playfer M.Plo Casasus T.Poikela F.Polci A.Poluektov I.Polyakov E.Polycarpo A.Popov D.Popov B.Popovici C.Potterat E.Price J.D.Price J.Prisciandaro A.Pritchard C.Prouve V.Pugatch A.Puig Navarro G.Punzi W.Qian R.Quagliani B.Rachwal J.H.Rademacker M.Rama M.S.Rangel I.Raniuk N.Rauschmayr G.Raven F.Redi S.Reichert M.M.Reid A.C.dos Reis S.Ricciardi S.Richards M.Rihl K.Rinnert V.Rives Molina P.Robbe A.B.Rodrigues E.Rodrigues J.A.Rodriguez Lopez P.Rodriguez Perez S.Roiser V.Romanovsky A.Romero Vidalt J.W.R onayne M.Rotondo J.Rouvinet T.Ruf P.Ruiz Valls J.J.Saborido Silva N.Sagidova P.Sail B.Saitta V.Salustino Guimaraes C.Sanchez Mayordomo B.Sanmartin Sedes R.Santacesaria C.Santamarina Rios M.Santimaria E.Santovetti A.Sarti C.Satriano A.Satta D.M.Saunders D.Savrina M.Schiller H.Schindler M.Schlupp M.Schmelling T.Schmelzer B.Schmidt O.Schneider A.Schopper M.Schubiger M.-H.Schune R.Schwemmer B.Sciascia A.Sciubba A.Semennikov N.Serra J.Serrano L.Sestini P.Seyfert M.Shapkin I.Shapoval Y.Shcheglov T.Shears L.Shekhtman V.Shevchenko A.Shires B.G.Siddi R.Silva Coutinho L.Silva de Oliveira G.Simi M.Sirendi N.Skidmore T.Skwarnicki E.Smith E.Smith I.T.Smith J.Smith M.Smith H.Snoek M.D.Sokoloff F.J.P.Soler F.Soomro D.Souza B.Souza De Paula B.Spaan P.Spradlin S.Sridharan F.Stagni M.Stahl S.Stahl S.Stefkova O.Steinkamp O.Stenyakin S.Stevenson S.Stoica S.Stone B.Storaci S.Stracka M.Straticiuc U.Straumann L.Sun W.Sutcliffe K.Swientek S.Swientek V.Syropoulos M.Szczekowski P.Szczypka T.Szumlak S.T'Jampens A.Tayduganov T.Tekampe M.T eklishyn G.Teilarini F.Teubert C.Thomas E.Thomas J.van Tilburg V.Tisserand M.Tobin J.Todd S.Tolk L.Tomassetti D.Tonelli S.Topp-Joergensen N.Torr E.Tournefier S.Tourneur K.Trabelsi M.T.Tran M.Tresch A.Trisovic A.Tsaregorodtsev P.Tsopelas N.Tuning A.Ukleja A.Ustyuzhanin U.Uwer C.Vacca V.Vagnonit G.Valentit A.Vallier R.Vazquez Gomez P.Vazquez Regueiro C.Vazquez Sierra S.Vecchi J.J.Velthuis M.Veltri G.Veneziano M.Vesterinen B.Viaud D.Vieira M.Vieites Diaz X.Vitasis-Cardona V.Volkov A.Vollhardt D.Volyanskyy D.Voong A.Vorobyev V.Vorobyev C.Voβ J.A.de Vries R.Waldi C.Wallace R.Wallace J.Walsh S.Wandernoth J.Wang D.R.Ward N.K.Watson D.Websdale A.Weiden M.Whitehead G.Wilkinson M.Wilkinson M.Williams M.P.Williams T.Williams F.F.Wilson J.Wimberley J.Wishahi W.Wislicki M.Witek G.Wormser S.A.Wotton S.Wright K.Wyllie Y.Xie Z.Xu Z.Yang J.Yu X.Yuan O.Yushchenko M.Zangoli M.Zavertyaev L.Zhang Y.Zhang A.Zhelezov A.Zhokhov L.Zhong S.Zucchelli | 2016 | Chinese Physics C2016，40，1： | 23 |
| 3 | Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis显示文摘AIM: To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis. METHODS: Donor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS: All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION: Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis. | David Philippe Laurent Favre Francis Foata Oskar Adolfsson Genevieve Perruisseau-Carrier Karine Vidal Gloria Reuteler Johanna Dayer-Schneider Christoph Mueller Stéphanie Blum | 2011 | World Journal of Gastroenterology2011，17，4： | 12 |
| 4 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 5 | 应用固相萃取高效液相色谱-质谱法测定水中多种农药残留显示文摘应用HLB固相萃取高效液相色谱-质谱法同时测定水中杀虫剂、杀菌剂、除草剂、杀螨剂、杀线虫剂等5类30种农药残留,标准曲线决定系数r2均大于0.99,标准添加回收率达76%￣107%,平均为87.9%。在实际测定的10个水样中,有个水样的杀铃脲(Triflumuron)含量超标。 | 申义珍 J.L.Martinez Vidal R.Romero Gonealez M.E.Hernandez Torres | 2006 | 农业环境科学学报2006，25，B09： | 9 |
| 6 | hsa-miR-29c and hsa-miR-135b differential expression aspotential biomarker of gastric carcinogenesis显示文摘AIM: To investigate the expression profiles of hsa-mi R-29 c and hsa-mi R-135 b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS: The expression levels of hsa-mi R-29 c and hsa-mi R-135 b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinaltype gastric adenocarcinoma were analysed using quantitative real-time PCR. The difference between hsa-mi R-29 c and hsa-mi R-135 b expression profiles in the grouped samples was evaluated by ANOVA and Student's t-test tests. The results were adjusted for multiple testing by using Bonferroni's correction. P values ≤ 0.05 were considered statistically significant. To evaluate hsa-mi R-29 c and hsa-mi R-135 b expressions as potential biomarkers of gastric carcinogenesis, we performed a receiver operating characteristic curve analysis and the derived area under the curve, and a Categorical Principal Components Analysis. In silico identification of the genetic targets of hsa-mi R-29 c and hsa-mi R-135 b was performed using different prediction tools, in order to identify possible genes involved in gastric carcinogenesis.RESULTS: The expression levels of hsa-mi R-29 c were higher in normal gastric mucosal samples, and decreased progressively in non-atrophic chronic gastritis samples, intestinal metaplasia samples and intestinal-type gastric adenocarcinoma samples. The expression of hsa-mi R-29 c in the gastric lesions showed that non-atrophic gastritis have an intermediate profile to gastric normal mucosa and intestinal-type gastric adenocarcinoma, and that intestinal metaplasia samples presented an expression pattern similar to that in intestinal-type gastric adenocarcinoma. This micro RNA(mi RNA) has a good discriminatory accuracy between normal gastric samples and(1) intestinal-type gastric adenocarcinoma; and(2) intestinal metaplasia, and regulates the DMNT3 A oncogene. hsa-mi R-135 b is up-regulated in non-atrophic chronic gastritis and intestinal metaplasia samples and down-regulated in normal gastric mucosa and intestinal-type gastric adenocarcinoma samples. Non-atrophic chronic gastritis and intestinal metaplasia are significantly different from normal gastric mucosa samples. hsa-mi R-135 b expression presented a greater discriminatory accuracy between normal samples and gastric lesions. This mi RNA was associated with Helicobacter pylori presence in non-atrophic chronic gastritis samples and regulates the APC and KLF4 tumour suppressor genes.CONCLUSION: Our results provide evidence of epigenetic alterations in non-atrophic chronic gastritis and intestinal metaplasia and suggest that hsa-mi R-29 c and hsa-mi R-135 b are promising biomarkers of gastric carcinogenesis. | Amanda Ferreira Vidal Aline MP Cruz Leandro Magalhães Adenilson L Pereira Ana KM Anaissi Nélisson CF Alves Paulo JBS Albuquerque Rommel MR Burbano Samia Demachki Ândrea Ribeiro-dos-Santos | 2016 | World Journal of Gastroenterology2016，22，6： | 7 |
| 7 | Comparative stability analyses of traditional and selective room-and-pillar mining techniques for sub-horizontal tungsten veins显示文摘The stability and productivity concerning a modification on the traditional room and pillar for a new selective technique at the Portuguese Panasqueira Mine have been described.The traditional room-and-pillar stoping uses 5.0-m wide rooms with 3.0 m×3.0 m pillars,while the selective room-and-pillar mining technique consists in stoping with rooms of 4.0 m wide and pillars of 4 m×4 m with a subsequent selective cutting of the quartz veins at the mid pillar of approximately 0.5 m high,to obtain a pillar section with an area of 3.0 m×3.0 m.The stability and productivity analyses indicate that the selective technique obtains smaller average pillar safety factor,more rock mass displacement,more extraction and selectivity ratios,and ore grade improvement,compared with the traditional technique.These results show that the selective technique is also more convenient.This proposed selective room-and-pillar mining technique is applicable to any sub-horizontal narrow quartz veins with wolfram,gold,etc.such as the famous La Rinconada gold mine in the Peruvian Andes. | Vidal Felix Navarro Torres Carlos Dinis da Gama Matilde Costa e Silva Paula Falcao Neves Qiang Xie | 2011 | International Journal of Minerals,Metallurgy and Materials2011，18，1： | 7 |
| 8 | Non-invasive brain stimulation to promote motor and functional recovery following spinal cord injury显示文摘We conducted a systematic review of studies using non-invasive brain stimulation(NIBS: repetitive transcranial magnetic stimulation(r TMS) and transcranial direct current stimulation(t DCS)) as a research and clinical tool aimed at improving motor and functional recovery or spasticity in patients following spinal cord injury(SCI) under the assumption that if the residual corticospinal circuits could be stimulated appropriately, the changes might be accompanied by functional recovery or an improvement in spasticity. This review summarizes the literature on the changes induced by NIBS in the motor and functional recovery and spasticity control of the upper and lower extremities following SCI. | Aysegul Gunduz John Rothwell Joan Vidal Hatice Kumru | 2017 | Neural Regeneration Research2017，12，12： | 7 |
| 9 | Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study显示文摘AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic patients.METHODS This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours.RESULTS Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction. | Charlotte Nicolas Amelie Le Gouge Louis d’Alteroche Jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing Jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud Louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau Jean-Marc Perarnau STIC-TIPS group | 2017 | World Journal of Hepatology2017，9，27： | 6 |
| 10 | Chromium Adsorption in Different Mineralogical Fractions from Subtropical Soils显示文摘Safe application of chromium(Cr)-containing organic industrial wastes to soil requires considering the ability of the soil to adsorb Cr.In this study,the maximum Cr adsorption capacity was assessed for the bulk samples and their clay and iron-free clay fractions of four subtropical soils differing in mineralogy.To this end,the samples were supplied with Cr(III) nitrate solutions at pH 4.5 or5.5.The results of Cr(III) adsorption fitted to a Freundlich equation and the adsorption capacity was positively correlated with soil organic matter and iron oxide contents.The clay fractions adsorbed more Cr per unit mass than the bulk soils and the iron-free clay fractions.The Cr(III) adsorption capacity increased with increasing soil pH due to more charges on adsorbing surfaces.Our results suggest that the soils rich in organic matter and iron oxides and having a pH above 4.5 are suitable for application of Cr(III)-loaded industrial wastes. | Jovana BAVARESCO Jesse R. FINK Maria Lucia K. RODRIGUES Clesio GIANELLO Vidal BARRON Jose TORRENT | 2017 | Pedosphere2017，27，1： | 6 |
| 11 | 巴塞罗那波布雷诺旧工业区更新策略探析显示文摘2000年,巴塞罗那推出22@计划,将波布雷诺旧工业区改造为高新知识经济区。本文在分析该地区更新背景的基础上,介绍了波布雷诺工业区的更新策略。从复合功能重构、基础设施升级、公共空间优化、建筑保护改造四个方面,深入探析了巴塞罗那22@计划整体性的规划战略和以人为本的城市理念。 | 周婷 Miquel Vidal Pla | 2013 | 住区2013，，3： | 6 |
| 12 | Meiotic abnormalities in metaphase I human spermatocytes from infertile males: frequencies, chromosomes involved, and relationship with polymorphic karyotype and seminal parameters显示文摘这研究的目的是深入地看在 meiotic 异例和男不孕之间的关系,例如包含的染色体或与耐心的特征的关联的决心。为这个目的,从为生育力问题做咨询的个人的 31 件阴囊的组织样品的一个总数被分析。中期我房间用联合 Leishman 的顺序的方法论被评估在 situ 杂交协议的染色的过程和复合荧光。单位和 chiasmata 数每的 chromosomal 的数字二原子价被建立,个人的层次簇分析被执行。在再结合上的 seminogram 和 karyotype 的关系用泊松回归模型被评估。在这研究获得的结果与改变的 meiotic 行为显示出不肥沃的个人的一个重要百分比,主要在中等、大的染色体, univalents 的存在,和 tetraploid 中期的观察在 chiasmata 计数作为减小指定了。而且,数字和异例的类型被发现在一样的个人的房间之间不同,与正常 meiotic 行为和房间建议房间线的共存与畸形排队。另外,在中期的 chromosomal 畸形我显著地与 oligozoospermia 或多态的 karyotype 变体被联系。 | Zaida Sarrate Francesca Vidal Joan Blanco | 2014 | Asian Journal of Andrology2014，16，6： | 5 |
| 13 | The Role of Phosphorylation in Redox Regulation of Photosynthesis Genes psaA and psbA during Photosynthetic Acclimation of Mustard显示文摘对轻质量的坡度的长期的反应(LTR ) 在稠密的看台改进植物的性能和幸存。它包含编码 plastome 的基因 psaAB 的控制氧化还原作用的 transcriptional 规定(编码 photosystem 的 P700 apoproteins 我) 并且 psbA (编码 photosystem II 的 D1 蛋白质) 并且要求质体局部性的 kinases 的行动。为了学习潜力,在 LTR 期间 phosphorylation 事件影响质体基因表示,我们分析了芥末幼苗 acclimated 点亮赞成任何一个 photosystem 的来源我或 photosystem II。psaA 抄本的教材延期分析显示氧化还原作用规定发生在主要细菌的倡导者,建议质体编码了 RNA 聚合酶(锐气) 是为氧化还原作用信号的目标。包含锐气和另外的 DNA 有约束力的蛋白质的叶绿体蛋白质部分经由 heparin-Sepharose 层析从芥末被净化。这些部分的生物化学的性质在倡导者识别和特性上与特殊强调被分析, phosphorylation 状态,和 kinase 活动。结果证明 LTR 包含小 DNA 有约束力的蛋白质的行动;他们中的三个处于 phosphorylation 状态展出特定的变化。另外, Auto-phosphorylation 试金在内长的 kinase 活动的活动展出大差别。有 kinase 禁止者 H7 和 reductant DTT 的叶绿体连续接排的印刷物抄写实验显示 phosphorylation 事件为向 psaA 和 psbA 抄写开始的氧化还原作用信号的调停是必要的,但是要求一个 thiol 氧化还原作用信号的 synergistic 行动。数据支持那个氧化还原作用从 thylakoid 膜表明的想法经由 phosphorylation 事件被连接到基因表示;然而,这调停看起来要求交往的蛋白质而非简单 phosphorelay 的一个复杂网络。 | Sebastian Steiner Lars Dietzel Yvonne Schroter Vidal Fey Raik Wagner Thomas Pfannschmidt | 2009 | Molecular Plant2009，2，3： | 5 |
| 14 | Global standard names for the Lowermost Cambrian Series and Stage显示文摘 | Ed Landing Shanchi Peng Loren E. Babcock Gerd Geyer Malgorzata Moczydlowska- Vidal | 2007 | Episodes2007，30，4： | 5 |
| 15 | Cytokine production in patients with cirrhosis and TLR4 polymorphisms显示文摘AIM:To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.METHODS:The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms,and 10 wild-type patients matched for age,sex and degree of liver failure.TLR4 polymorphisms were determined by sequence-based genotyping.Cytokine production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide(LPS)and lipoteichoic acid(LTA)stimulation.RESULTS:Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients(78%vs 20%,P=0.02).Spontaneous production of interleukin(IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients[IL-6:888.7(172.0-2119.3)pg/m L vs 5540.4(1159.2-26053.9)pg/m L,P<0.001;IL-10:28.7(6.5-177.1)pg/m L vs 117.8(6.5-318.1)pg/m L,P=0.02].However,the production of tumor necrosis factor-α,IL-6 and IL-10 after LPS and LTA stimulation was similar in the two groups.CONCLUSION:TLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients,suggesting that they play a role in the development of cirrhosis complications. | Juan Camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente Maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 16 | International NeuroAIDS: prospects of HIV-1 associated neurological com-plications显示文摘Neurological complications associated with HIV-1/AIDS are being recognized with a high frequency that parallels the increased number of AIDS cases. The early infiltration by HIV-1 into the nervous system can cause primary and/or secondary neurological complications. The most common neurocognitive disorder is AIDS Dementia Complex (ADC). In developing countries of Asia the three most opportunistic infections are tuberculosis (TB), cryptococcosis, and Pneumocystis carinii pneumonia. Therefore, it is expected that secondary neurological complications due to TB and cryptococcosis will be the most common cause of morbility and mortality in HIV-1/AIDS cases in China. Research of NeuroAIDS in China is necessary to understand the impact and the biology of HIV-1 in the nervous system. Future studies would include, the molecular epidemiology and the description of opportunistic infections associated to HIV-1; the neuropathological description of primary and secondary HIV-1 complications in different groups; the HIV-1 neurot- ropism and immune response studies for China’s unique HIV-1 strains and recombinant forms derived from the nervous system, including experimental models such as the use of transgenic rats; and the study of potential resistant virus, primarily when the anti-retroviral therapy (ART) has not full access in the brain. | J Roberto TRUJILLO Gilberto JARAMILLO-RANGEL Marta ORTEGA-MARTINEZ Augusto C PENALVA de OLIVEIRA Jose E VIDAL Joseph BRYANT Robert C GALLO | 2005 | Cell Research2005，15，11： | 4 |
| 17 | Role of laryngeal mask airway in laparoscopic cholecystectomy显示文摘Laparoscopic cholecystectomy is one of the most commonly performed surgical procedures and the laryngeal mask airway(LMA) is the most common supraglottic airway device used by the anesthesiologists to manage airway during general anesthesia. Use of LMA has some advantages when compared to endotracheal intubation, such as quick and ease of placement, a lesser requirement for neuromuscular blockade and a lower incidence of postoperative morbididy. However, the use of the LMA in laparoscopy is controversial, based on a concern about increased risk of regurgitation and pulmonary aspiration. The ability of these devices to provide optimal ventilation during laparoscopic procedures has been also questioned. The most important parameter to secure an adequate ventilation and oxygenation for the LMA under pneumoperitoneum condition is its seal pressure of airway. A good sealing pressure, not only state correct patient ventilation, but it reduces the potential risk of aspiration due to the better seal of airway. In addition, the LMAs incorporating a gastric access, permitting a safe anesthesia based on these commented points. We did a literature search to clarify if the use of LMA in preference to intubation provides inadequate ventilation or increase the risk of aspiration in patients undergoing laparoscopic cholecystectomy. We found evidence stating that LMA with drain channel achieves adequate ventilation for these procedures. Limited evidence was found to consider these devices completely safe against aspiration. However, we observed that the incidence of regurgitation and aspiration associated with the use of the LMA in laparoscopic surgery is very low. | José M Belena Ernesto Josué Ochoa Mónica Núnez Carlos Gilsanz Alfonso Vidal | 2015 | World Journal of Gastrointestinal Surgery2015，7，11： | 4 |
| 18 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 19 | 海南省HIV-1基因亚型分析显示文摘目的分析海南省人类免疫缺陷病毒-1(HIV-1)基因亚型,监测HIV毒株的流行状况。方法从88份HIV-1抗体阳性的血浆中提取RNA,逆转录后采用PCR法扩增HIV-1基因序列中的env及pol基因,对扩增产物进行核苷酸序列测定,经比对分析而确定基因亚型。构建最大似然(ML)进化树,分析感染者间的传播链。结果88份样品中,有83份样品被扩增出HIV-1的env及pol基因片段;共发现6种HIV-1亚型和重组型,其中CRF01-AE亚型70份,B′亚型8份,C亚型2份,B亚型和CRF08-BC、CRF01-AE/B′重组亚型各1份。在ML进化树上83份样品分成4个传播群(66/83)和非传播群(17/83),其中传播群1最庞大(59/83)。结论海南省HIV/AIDS的HIV-1基因亚型至少有6种,其中CRF01-AE为主要亚型,占84.33%(70/83),主要分布在静脉吸毒者及其性伴侣之间,形成了一个庞大的传播群。其次为B′亚型(9.6%)。另外的4种亚型(6%)仅见单个病例。提示海南省静脉吸毒为主要的感染途径(67.5%);经性接触传播的亚型种类复杂多样,包括本次检出的全部亚型和重组株。 | 符鹏 邓巍 鲍琳琳 Nicole Vidal 何启亚 秦川 Martine Peeters Eric Delaporte Jean-Marie Andrieu 王召乾 邝继深 张帆 胡玉銮 卢葳 | 2009 | 中国公共卫生2009，25，9： | 4 |
| 20 | Endocrine disrupting chemicals in mixture and obesity,diabetes and related metabolic disorders显示文摘Obesity and associated metabolic disorders represent a major societal challenge in health and quality of life with large psychological consequences in addition to physical disabilities. They are also one of the leading causes of morbidity and mortality. Although, different etiologic factors including excessive food intake and reduced physical activity have been well identified, they cannot explain the kinetics of epidemic evolution of obesity and diabetes with prevalence rates reaching pandemic proportions. Interestingly, convincing data have shown that environmental pollutants, specifically those endowed with endocrine disrupting activities, could contribute to the etiology of these multifactorial metabolic disorders. Within this review, we will recapitulate characteristics of endocrine disruption. We will demonstrate that metabolic disorders could originate from endocrine disruption with a particular focus on convincing data from the literature. Eventually, we will present how handling an original mouse model of chronic exposition to a mixture of pollutants allowed demonstrating that a mixture of pollutants each at doses beyond their active dose could induce substantial deleterious effects on several metabolic end-points. This proof-of-concept study, as well as other studies on mixtures of pollutants, stresses the needs for revisiting the current threshold model used in risk assessment which does not take into account potential effects of mixtures containing pollutants at environmental doses, e.g., the real life exposure. Certainly, more studies are necessary to better determine the nature of the chemicals to which humans are exposed and at which level, and their health impact. As well, research studies on substitute products are essential to identify harmless molecules. | Brigitte Le Magueresse-Battistoni Emmanuel Labaronne Hubert Vidal Danielle Naville | 2017 | World Journal of Biological Chemistry2017，8，2： | 4 |
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