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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Architectural factors influencing the sense of home in nursing homes: An operationalization for practice显示文摘 | A. Eijkelenboom H. Verbeek E. Felix J. van Hoof | 2017 | Frontiers of Architectural Research2017，6，2： | 5 |
| 3 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 4 | Random Comparison of Guaiac and Immunochemical Fecal Occult Blood Tests for Colorectal Cancer in a Screening Population显示文摘 | Leo G. van Rossum Anne F. van Rijn Robert J. Laheij Martijn G. van Oijen Paul Fockens Han H. van Krieken Andre L. Verbeek Jan B. Jansen Evelien Dekker | 2008 | Gastroenterology2008，，1： | 2 |
| 5 | Selecting copulas for risk management显示文摘 | Erik Kole Kees Koedijk Marno Verbeek | 2007 | Journal of Banking and Finance2007，，8： | 2 |
| 6 | Two Greek Siblings with Sepiapterin Reductase Deficiency 显示文摘 | VERBEEK M M WILLEMSEN M A A P WEVERS R A eL al | 2008 | Molecular Genetics and Metabolism2008，94，4： | 1 |
| 7 | Cell li- neage involvement in four patients with myelodysplastic syndrome and t(1;7) or trisomy 8 studied by simultaneous immunophenotyping and fluorescence in situ hybridiza- tion显示文摘 | Nylund SJ Verbeek W Larramendy ML | 1993 | Cancer Genet Cytogenet1993，70，2： | 1 |
| 8 | Protein S-100B, neuron-specific enolase (NSE), myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and blood of neurological patients显示文摘 | Lamers KJ Vos P Verbeek MM | 2003 | Brain Res Bull2003，61，3： | 1 |
| 9 | Identification of a novel SCA locus (SCA19) in a Dutch autosomal dominant cerebellar ataxia family on chromosome region 1p21-q21显示文摘 | Verbeek DS Schelhaas JH Ippel EF | 2002 | Hum Genet2002，111，45： | 1 |
| 10 | Chemo- therapeutic treatment for spinal tuberculosis 显示文摘 | Van Loenhout-Rooyaekers J/I Verbeek AL Jutte PC | 2002 | Int J Tuberc Lung Dis2002，6，3： | 1 |
| 11 | Protein S-100B, neu- ron-specific enolase ( NSE ) , myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and blood of neurological patients 显示文摘 | Lamers KJ Vos P Verbeek MM | 2003 | Brain Res Bull2003，61，3： | 1 |
| 12 | Prognostic Factors for Duration of Sick Leave in Patients Sick Listed with Acute Low Back Pain:A Systematic Review of the Litera-ure显示文摘 | Steenstra I Verbeek J Heymans M | 2005 | Occup Environ Med2005，62，12： | 1 |
| 13 | Polymerase chain reaction for probe synthesis and for direct amplificatlon in detection of bovine coronavirus显示文摘 | Verbeek A Tijssen P | 1990 | J Virol Methods1990，29，3： | 1 |
| 14 | Preparation of esters of gallic acid with higher primary alcohols 显示文摘 | KERK G J M van der VERBEEK J H CLETON J C F | 1951 | Rec Tray Chim1951，70，： | 1 |
| 15 | Dosage Spectrophotom 6 trique du Fer Ferreux en Pr 6 sence D'un Exc s de fer Ferrique, et du fer Ferrique En Pr sence D'Un Exc s De Fer Ferreux显示文摘 | Verbeeks F | 1961 | Bulletin des Soci 6 t s Chimiques Beiges1961，70，78： | 1 |
| 16 | Identification of coop- erating oncogenes in E mu-myc transgenic mice by provirus tagging 显示文摘 | van-Lohuizen M Verbeek S Scheijen B | 1991 | Cell1991，65，5： | 1 |
| 17 | Protein S-100B,neuron-specific enolase (NSE),myelin basic Protein(MBP) and glial fibrillary acidic Protein(GFAP) in cerebrospinal fluid(CSF) and blood of neurological Patients显示文摘 | Lamers KJ Vos P Verbeek MM | | 0，，03： | 1 |
| 18 | Grb2 overexpression in nuclei and cytoplasm of human breast cells: a histochemical and biochemical study of normal and neoplastic mammary tissue specimens显示文摘 | Verbeek BS ADRIAANSEN-SLOT SS RIJKSEN G | 1997 | J Pathol1997，183，2： | 1 |
| 19 | Material Hermeneutics 显示文摘 | Verbeek P | 2003 | Techne2003，7，3： | 1 |
| 20 | Protein S-IOOB, neuron-specific enolase (NSE), myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and blood of neurological patients显示文摘 | Lamers KJ Vos P Verbeek MM | 2003 | Brain Res Bull2003，61，3： | 1 |
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