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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Use of amorphous dressing in the skin care of patients after radiotherapy显示文摘 | Amaral WC Ritort F | 1998 | Rev-Enferm1998，，243： | 1 |
| 3 | Depth object recovery using radial basis function 显示文摘 | Cuevas F J Servin M Vera R R | 1999 | Opt Commun1999，163，： | 1 |
| 4 | Expression of granulocyte macrophage-colony-stimulating factor receptors in human prostate cancer显示文摘 | Rivas CI Vera JC Delgado-Lopez F | 1998 | Blood1998，91，3： | 1 |
| 5 | An examination of the challenges daughters face in family business succession显示文摘 | Vera C F and Dean M A | 2005 | Family Business Review2005，18，4： | 1 |
| 6 | Protein expression pat- terns of ezrin are predictors of progression in T1G3 blad- der tumours treated with nonmaintenance bacillus Calmette-Guerin 显示文摘 | Palou J Algaba F Vera I | 2009 | Eur Urol2009，56，5： | 1 |
| 7 | Passive smoking and other risk factors associated to the lower respiratory illnesses in sucking infants显示文摘 | Galve Royo F Garcia Vera C Rubio Sevillano FJ | 1998 | Aten Primaria1998，22，1： | 1 |
| 8 | Study of a downdraft gasifier and externally fired gas turbine for olive industry wastes 显示文摘 | VERA D JURADO F CARPIO J | 2011 | Fuel Processing Technology2011，92，10： | 1 |
| 9 | Influence of DNA repair gene polymorphisms of hOGG1, XRCC1, XRCC3, ERCC2 and the folate metabolism gene MTHFR on chromosomal aberration frequencies显示文摘 | CAMILLA F S MARIT S VERA H | 2006 | Mut Res2006，602，： | 1 |
| 10 | Protein expression patterns ofezrin are predictors of progression in T1G3 bladder tumours trea-ted with nonmaintenance bacillus calmette-guerin显示文摘 | Paiou J Algala F Vera I | 2009 | Eur Urol2009，56，： | 1 |
| 11 | Inflammatory bowel disease patient satisfaction with healthcare services received? Physicians' and nurses' perceptions 显示文摘 | Casellas F Vera I Ginard D | 2013 | Rev Esp Enferm Dig2013，105，7： | 1 |
| 12 | A Molecular CT Blood Pool Contrast Agent显示文摘 | Vera D R Mattroy R F | 2002 | Academic Radiology2002，9，： | 1 |
| 13 | User rationality and optimal park-and-ride location under potential demand maximization显示文摘 | Veras J H Yushimito W F Vera F A | 2012 | Transportation Research Part B2012，46，8： | 1 |
| 14 | Pancreatic abscess caused by Candida following wide-spectrum antibiotic treatment 显示文摘 | De Vera F Martinez JF Clara Verdu R | 1998 | Gastroenterol Hepatol1998，21，4： | 1 |
| 15 | Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47 phox induced by angiotensin Ⅱ in rat aorta显示文摘 | Sanchez M Lodi F Vera R | 2007 | Nutr2007，137，： | 1 |
| 16 | En- hancing uranium solubilization in soils by citrate, EDTA, and EDDS chelating amendments 显示文摘 | LOZANO J C BLANCO RODI GUEZ P VERA TOME F | 2011 | Journal of Hazardous Materials2011，198，： | 1 |
| 17 | EDIPS:an easy to deploy indoor positioning system to support loosely coupled mobile work显示文摘 | Vera R Ochoa S F Aldunate R G | | 0，，04： | 1 |
| 18 | Systems biology of JAK- STAT signalling in human malignancies 显示文摘 | Vera J Rateitschak K Lange F | 2011 | Prog Biophys Mol Biol2011，106，2： | 1 |
| 19 | Single-crystal IR spectroscopy of very strong hydrogen bonds in pectolite, NaCa2 and serandite, NaMn2显示文摘 | Vera M F Hammer Eugen Libowitzky George R Rossman | 1998 | American Mineralogist1998，83，6： | 1 |
| 20 | Different strategies for purification of antimicrobial peptides from lactic acid bacteria显示文摘 | Vera Pingitore E Salvucci E Sesma F | 2007 | Applied Microbiology2007，，： | 1 |
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