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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects. | Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 3 | Filamentous fungal characterizations by matrix- assisted laser desorption/ionization time of flight mass spectrometry 显示文摘 | SANTOS C PATERSON R R VENANCIO A | 2010 | J Appl Microbiol2010，108，： | 1 |
| 4 | Species identi- fication of Aspergillus section Flavi isolates from Portuguese al- monds using phenotypic, including MALDI-TOF ICMS, and molecular approaches 显示文摘 | Rodrigues P Santos C Venancio A Lima N | 2011 | Journal of applied microbiology2011，111，4： | 1 |
| 5 | Performance of polyaniline electro-synthesized in the presence of trichloroacetic acid as a battery cathode显示文摘 | Venancio E C Motheo A J Amaral F A | 2001 | J Power Sources2001，94，1： | 1 |
| 6 | Successful Treatment of Severe Gastrointestinal Bleeding Secondary to Crohn Disease with Recombinant Factor VIIa显示文摘 | Eva Girona Joaquín Borrás-Blasco Venancio Conesa-García Andrés Navarro-Ruiz Javier Solís Mariana Fe García-Sepulcre Israel Oliver-García | 2007 | Southern Medical Journal2007，，6： | 1 |
| 7 | 查看详情显示文摘 | A G MacDiarmid E C Venancio P C Wang | | 0，，5： | 1 |
| 8 | Nanostructured films of perylene derivatives: High performance materials for taste sensor applications 显示文摘 | CONSTANTINO C J L ANTUNES P A VENANCIO E C | 2004 | Sensor Letters2004，2，2： | 1 |
| 9 | Interaction mechanism of poly ( o - ethoxyani- line) and collagen blends 显示文摘 | PIZA M A CONSTANTINO C J L VENANCIO E C | 2003 | Polymer2003，44，： | 1 |
| 10 | Mycotoxin-producing and other fungi isolated from grapes for wine production, with particular emphasis on ochratoxin A 显示文摘 | Serra R Braga A Venancio A | 2005 | Research in Microbiology2005，156，4： | 1 |
| 11 | Physiological Effects of Strobilurin Fungicides on Plants显示文摘 | VENANCIO W S RODRIGUES M A T BEGLIOMINI E | 2003 | Publication UEPG Ponta Grossa2003，9，3： | 1 |
| 12 | A modal superposition pseudo-force method for dynamic analysis of structural systems with non- proportional damping显示文摘 | Claret A M Venancio F F | 1991 | Earthquake Engineering and Structural Dynamics1991，20，： | 1 |
| 13 | Physiological effects of strobilurin fungicides on plants显示文摘 | VENANCIO W S Rodrigues M A T Begliomini E | 2003 | Publ UEPG Exact Soil Sci Agr Sci Eng Ponta Grossa2003，9，3： | 1 |
| 14 | Irradiation for Mold and Mycotoxin Control: A Review 显示文摘 | Calado T Venancio A Abrunhosa L | 2014 | Comprehensive Re- views in Food Science and Food Safety2014，13，5： | 1 |
| 15 | Raman microspectroscopy of some iron oxides and oxyhydroxides 显示文摘 | D L A de Faria S Venancio Silva M T Oliveira | 1997 | J Raman Spectrosc1997，28，： | 1 |
| 16 | Biodegradation of ochratoxin A by fungi isolated from grapes显示文摘 | Abrunhosa L Serra R Venancio A | 2002 | Journal of A- gricultural and Food Chemistry2002，50，25： | 1 |
| 17 | Ozone applications to prevent and degrade mycotoxins: a review 显示文摘 | Freitas - Silva 0 Venancio A | 2010 | Drug Metab Rev2010，42，4： | 1 |
| 18 | The azanes : A class of material incorporating nano/micro self- assembled hollow spheres obtained by aqueous oxidative polymerization of ailine显示文摘 | VENANCIO E C WANG P C MACDIARMID A G | 2006 | Synthetic Metals2006，156，516： | 1 |
| 19 | Separation of endopolygalacturonase using aqueous two-phase partitioning显示文摘 | WU Y T PEREIRA M VENANCIO A | 2001 | J Chromatogr A2001，929，： | 1 |
| 20 | Fate of ochratoxin A during a vinification trial显示文摘 | Femsndes A Venancio A Moura F | 2003 | Aspects of Applied Biology2003，68，： | 1 |
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