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| 1 | CITED2 and the modulation of the hypoxic response in cancer显示文摘CITED2(CBP/p300-interacting transactivator with Glu/Asp-rich C-terminal domain,2)is a ubiquitously expressed protein exhibiting a high affinity for the CH1 domain of the transcriptional co-activators CBP/p300,for which it competes with hypoxia-inducible factors(HIFs).CITED2 is particularly efficient in the inhibition of HIF-1α-dependent transcription in different contexts,ranging from organ development and metabolic homeostasis to tissue regeneration and immunity,being also potentially involved in various other physiological processes.In addition,CITED2 plays an important role in inhibiting HIF in some diseases,including kidney and heart diseases and type 2-diabetes.In the particular case of cancer,CITED2 either functions by promoting or suppressing cancer development depending on the context and type of tumors.For instance,CITED2 overexpression promotes breast and prostate cancers,as well as acute myeloid leukemia,while its expression is downregulated to sustain colorectal cancer and hepatocellular carcinoma.In addition,the role of CITED2 in the maintenance of cancer stem cells reveals its potential as a target in non-small cell lung carcinoma and acute myeloid leukemia,for example.But besides the wide body of evidence linking both CITED2 and HIF signaling to carcinogenesis,little data is available regarding CITED2 role as a negative regulator of HIF-1αspecifically in cancer.Therefore,comprehensive studies exploring further the interactions of these two important mediators in cancer-specific models are sorely needed and this can potentially lead to the development of novel targeted therapies. | Mónica T Fernandes Sofia M Calado Leonardo Mendes-Silva JoséBraganca | 2020 | World Journal of Clinical Oncology2020，11，5： | 2 |
| 2 | Regulation of the germinal center response by microRNA-155显示文摘 | THAI T H CALADO D P CASOLA S | 2007 | Science2007，316，5824： | 1 |
| 3 | Image retrieval using multiple evidence ranking 显示文摘 | COELHO T A S CALADO P P SOUZA L V | 2004 | IEEE Trans on Knowledge and Data Engineering2004，16，4： | 1 |
| 4 | Current concepts in the pathophysiology and treatment of aplastic ane- mia显示文摘 | YOUNG N S CALADO R T SCHEINBERG P | 2006 | Blood2006，108，8： | 1 |
| 5 | Apla-stic anemia显示文摘 | YOUNG N S SCHEINBERG P CALADO R T | 2008 | Curr Opin Hematol2008，15，： | 1 |
| 6 | Telomerase: not just for the elongation of telomeres显示文摘 | Calado R T Chen J C | 2006 | BioEssays2006，28，2： | 1 |
| 7 | Aplastic anemia 显示文摘 | Young N S Scheinberg P Calado R T | 2008 | Curr Opin Hematol2008，15，3： | 1 |
| 8 | Regulation of the germinal center response by mieroRNA-155显示文摘 | Thai T H Calado D P Casola S | 2007 | Science2007，316，5824： | 1 |
| 9 | Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia 显示文摘 | Yamaguchi H Calado R T Ly H | 2005 | N Engl J Med2005，352，14： | 1 |
| 10 | Current concepts in the patho- physiology and treatment of aplastic anemia 显示文摘 | Young N S Calado R T Scheinberg P | 2006 | Blood2006，108，8： | 1 |
| 11 | Current con- cepts in the pathophysiologyand treatment of aplastic anemi- a显示文摘 | Young N S Calado R T Scheinberg P | 2006 | Blood2006，108，8： | 1 |
| 12 | Genetic Varia-tion in telomerie repeat binding factors 1 and 2 in aplastic anemia 显示文摘 | Savage S A Calado R T Xin Z T | 2006 | Exp Hematal2006，34，5： | 1 |
| 13 | Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein显示文摘 | Lu L F Thai T H Calado D P | 2009 | Immunity2009，30，1： | 1 |
| 14 | Current concepts in the pathophysiology and treatment of aplastic anemia 显示文摘 | Young N S Calado R T Scheinberg P | 2006 | Blood2006，108，8： | 1 |
| 15 | Foxp3-dependent micro- RNA-155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein显示文摘 | Lu L F Thai T H Calado D P | 2009 | Immunity2009，30，1： | 1 |
| 16 | Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic a- nemia显示文摘 | YAMAQUCHI H CALADO R T LY H | 2005 | N Engl J Med2005，352，14： | 1 |
| 17 | Irradiation for Mold and Mycotoxin Control: A Review 显示文摘 | Calado T Venancio A Abrunhosa L | 2014 | Comprehensive Re- views in Food Science and Food Safety2014，13，5： | 1 |
| 18 | Mtltations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia显示文摘 | Yamaguchi H Calado R T Ly H | 2005 | N Engl J Med2005，352，14： | 1 |
| 19 | Gemini sur- factant - protein interactions : Effect of pH, temperature, and surfactant stereochemistry 显示文摘 | FAUSTINO C M C CALADO A R T GARCIA -RIO L | 2009 | Biomacromolecules2009，10，： | 1 |
| 20 | Functional characteriza- tion of natural telomerase mutations found in patients with hemato- logical disorders显示文摘 | Xin Z T Beauchamp A D Calado R T | 2007 | Blood2007，109，2： | 1 |
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