|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery显示文摘AIM: To evaluate the surface expression of triggering receptor on myeloid cell 1 (TREM-1), class Ⅱ major histocompatibility complex molecules (HLA-DR), andthe expression of the splicing variant (svTREM-1) ofTREM-1 in septic patients and those subjected to major abdominal surgery.METHODS: Using flow cytometry, we examined the surface expression of TREM-1 and HLA-DR in peripheral blood monocytes from 11 septic patients, 7 elective gastrointestinal surgical patients, and 10 healthy volunteers. svTREM-1 levels were analyzed by RT-PCR. RESULTS: Basal expression of TREM-1 and HLA-DR in healthy volunteers was 35.91±14.75 MFI and75.8±18.3%, respectively. In septic patients, TREM-1 expression was 59.9±23.9 MFI and HLA-DR expression was 44.39±20.25%, with a significant differencebetween healthy and septic groups (P<0.05) for bothmolecules. In the surgical patients, TREM-1 and HLA-DR expressions were 56.8±20.85 MFI and 71±13.8% before surgery and 72.65±29.92 MlFI and 72.82±22.55% after surgery. TREM-1 expression was significantly different(P = 0.0087) between the samples before and aftersurgery and svTREM-1 expression was 0.8590±0.1451 MF1, 0.8820±0.1460 MF1, and 2.210±0.7873MF1 in the healthy, surgical (after surgery) and septic groups, respectively. There was a significant difference (P = 0.048) in svTREM-1 expression between the healthy and surgical groups and the septic group.CONCLUSION: TREM-1 expression is increased during systemic inflammatory conditions such as sepsis and the postoperative phase. Simultaneous low expression of HLA-DR molecules correlates with the severity of illness and increases susceptibility to infection. Additionally, TREM-1 expression is distinctly different in surgical patients at different stages of the inflammatory response before and after surgery. Thus, surface TREM-1 appears to be an endogenous signal during the course of the inflammatory response. svTREM-1 expression is significantly increased during sepsis, appearing to be an indicator of severity of illness. Together, these data indicate that TREM-1 may play an important role in establishing and amplifying the systemic inflammatory response. TREM-1, HLA-DR, and svTREM-1 expression analysis can provide useful diagnostic and prognostic indicators during SIRS, CARS, and sepsis. | Nestor González-Roldán Eduardo Ferat-Osorio Rosalía Aduna-Vicente Isabel Wong-Baeza Noemí Esquivel-Callejas Horacio Astudillo-de la Vega Patricio Sánchez-Fernández Lourdes Arriaga-Pizano Miguel Angel Villasís-Keever Constantino López-Macías Armando Isibasi | 2005 | World Journal of Gastroenterology2005，11，47： | 9 |
| 2 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 3 | Heavy metal sorption and desorption capacity of soils containing endogenous contaminants 显示文摘 | COVELO E F VEGA F A ANDRADE M L | 2007 | Journal of Hazardous Materials2007，143，： | 1 |
| 4 | High throughput production, screening and analysis of adeno-associated viral vectors显示文摘 | Drittanti L Rivet C Manceau P Danos O Vega M | 2000 | Gene Ther2000，7，： | 1 |
| 5 | Stress proteins induced by arsenic 显示文摘 | Del Razo L M QuintaniUa - Vega B Brambila - Colom- bres E | 2001 | Toxicology and Applied Pharmacology2001，177，2： | 1 |
| 6 | Public perception of stroke inSpain显示文摘 | Segura T Vega G López S | 2003 | Cerebrovasc Dis2003，16，1： | 1 |
| 7 | Depth of water uptake in woody plants relates to groundwa-ter 1eve|l and vegetation structure along a topographic gra- dient in a neotropical savanna 显示文摘 | Rossatto D R Silva L C R Villalobos - Vega R | 2012 | Environmental and Ex- perimental Botany2012，77，： | 1 |
| 8 | Retent ion of heavymetal ions in bentonites from Grau Reg ion (North crn Peru) 显示文摘 | AYALA J VEGA J L ALVAREZ R | 2008 | Environmental Geology2008，53，6： | 1 |
| 9 | Causes of high blood cholesterol显示文摘 | Grundy S M Vega G L | 1990 | Circulation1990，81，2： | 1 |
| 10 | MCP- 1, RANTES, and SDF- 1 polymorphisms in Mexican Patients with systemic lupus erythematosus 显示文摘 | Guadalupe L Soto - Vega E Atisha - Fregoso Y et al | 2007 | Hum Immunol2007，68，： | 1 |
| 11 | Outcomes and Patient Satisfaction After Presbyopic Bilateral Lens Exchange with the ReSTOR IOL in Emmetropic Patients显示文摘 | Alfonso JF Fernandez-- Vega L Valcarcel B | 2010 | Cataract Refract Surg2010，1，28： | 1 |
| 12 | First report of bacterial blight caused by Pseudomonas viridiflava on pea in Spain显示文摘 | Martin-Sanz A Palomo J L Perez de la Vega M | 2010 | Plant Disease2010，94，1： | 1 |
| 13 | Differential effects of trivalent and pentavalent arsenicalson cell proliferation and cytokine secretion in normal human epidermal keratinocytes显示文摘 | Vega L Styblo M Patterson R | 2001 | Toxicol Appl Pharmaco2001，172，3： | 1 |
| 14 | A global map of p53 transcription-factor binding sites in the human genome 显示文摘 | Wei C L Wu Q Vega V B | 2006 | Cell2006，124，1： | 1 |
| 15 | Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells 显示文摘 | Styblo M Del Razo L M Vega L | 2000 | Ar- chives of Toxicology2000，74，6： | 1 |
| 16 | Monitoring of pesticides in agricultural water and soil samples from Andalusia by liquid chromatography coupled to mass spectrometry 显示文摘 | Belmonte Vega A Garrido Frenich A Martfnnez Vidal J L | 2005 | Analytical Chimica Acta2005，538，： | 1 |
| 17 | A nonparametric VSS NLMS algorithm 显示文摘 | BENESTY J REY H VEGA L R | 2006 | IEEE Signal Processing Letters2006，13，： | 1 |
| 18 | Infectivity of a bulgarian and an American strain of Steinernema carpocapsae against codling moth显示文摘 | Vega F E Lacey L A Reid A P | | 0，，： | 1 |
| 19 | Correlation between risk aversion and wealth distribution显示文摘 | Iglesias J R Goncalves S Vega J L | 2004 | Physica A2004，342，6： | 1 |
| 20 | Acid-sensing ion channels (ASICs) in the taste buds of adult zebrafish显示文摘 | E. Vi?a V. Parisi R. Cabo R. Laurà S. López-Velasco A. López-Mu?iz O. García-Suárez A. Germanà J.A. Vega | 2013 | Neuroscience Letters2013，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员