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| 1 | Capecitabine for locally advanced and metastatic colorectal cancer:A review显示文摘Capecitabine (Xeloda) is an oral fluoropyrimidine which is produced as a pro-drug of fluorouracil, and shows improved tolerability and intratumor drug concentrations following its tumor-specif ic conversion to the active drug. We have searched the Pubmed and Cochrane databases from 1980 to 2009 with the purpose of reviewing all available information on Capecitabine, focusing on its clinical effectiveness against colorectal cancer. Special attention has been paid to trials that compared Capecitabine with standard folinic acid (leucovorin, LV)-modulated intravenous 5-fluorouracil (5-FU) bolus regimens in patients with metastatic colorectal cancer. Moreover the efficacy of Capecitabine on metastatic colorectal cancer, either alone or in various combinations with other active drugs such as Irinotecan and Oxaliplatin was also assessed. Finally, neoadjuvant therapy con- sisting of Capecitabine plus radiation therapy, for locally advanced rectal cancer was analysed. This combination of chemotherapy and radiotherapy has a special role in tumor down staging and in sphincter preservation for lower rectal tumors. Comparative trials have shown that Capecitabine is at least equivalent to the standard LV-5-FU combination in relation to progression-free and overall survival whilst showing a better tolerability prof ile with a much lower incidence of stomatitis. It is now known that Capecitabine can be combined with other active drugs such as Irinotecan and Oxaliplatin. The combination of Oxaliplatin with Capecitabine represents a new standard of care for metastatic colorectal cancer. Combinating the Capecitabine-Oxaliplatin regimen with promising new biological drugs such as Bevacizumab seems to give a realistic prospect of further improvement in time to progression of metastatic disease. Moreover, preoperative chemo-radiation using oral capecitabine is better tolerated than bolus 5-FU and is more effective in the promotion of both down-staging and sphincter preservation in patients with locally advanced rectal cancer. Finally, the outcomes of recently published trials suggest that capecitabine seems to be more cost effective than other standard treatments for the management of patients with colorectal cancer. | Georgios V Koukourakis Georgios Zacharias John Tsalafoutas Dimitrios Theodoridis Vassilios Kouloulias | 2010 | World Journal of Gastrointestinal Oncology2010，2，8： | 4 |
| 2 | Duplicate record detection:a survey显示文摘 | Ahmed K E Panagiotis G I Vassilios S V | 2007 | IEEE Transactions on Knowledge and Data Engieering2007，19，1： | 1 |
| 3 | Learning to cruise: Bern- stein's theory applied to skill acquisition during infancy显示文摘 | HAEHL V VASSILIOS V BEVERLY U | 2000 | Human movement science2000，19，5： | 1 |
| 4 | Oil- in- water emulsions stabilized by chitin nanocrystal panicles 显示文摘 | Maria V Tzoumaki Thomas Moschakis Vassilios Kiosseoglou | 2011 | Food Hydrocolloids2011，25，： | 1 |
| 5 | Duplicate record detection: a survey显示文摘 | AHMED K E PANAGIOTIS G I VASSILIOS S V | 2007 | IEEE Transaction on Knowledge and Data Eng2007，19，1： | 1 |
| 6 | Duplicate Record Detection: A Survey显示文摘 | Ahmed K E Panagiotis G I Vassilios S V | 2007 | IEEE Transactions on Knowledge and Data Engineering2007，19，1： | 1 |
| 7 | Inflammatory CNS demyelination:histopathologic correlation with in vivo quantitative proton MR spectroscopy显示文摘 | Andreas B Harald B Vassilios V | 1999 | AJNR1999，20，9： | 1 |
| 8 | Speaker adaptation using combined transform and Bayesian methods 显示文摘 | Vassilios V D Leonardo G N | 1996 | IEEE Trans on Speech and Audio Processing1996，4，4： | 1 |
| 9 | Maximum likelihood stochastic transformation adaptation of hidden Markov models 显示文摘 | Diakoloukas Vassilios D Digalakis Vassilios V | 1999 | IEEE Trans on Speech and Audio Processing1999，7，2： | 1 |
| 10 | Recent advances in chemistry,biology and biotechnology of alkannins and shikonins显示文摘 | Vassilios P Papageorgiou Andreana N Assimopoulou V F Samanidou | 2006 | Curr Org Chem2006，10，： | 1 |
| 11 | Interleukin 8 and Susceptibility to Coronary Artery Disease:a Population Genetics Perspective 显示文摘 | Konstantina V Stavros A Vassilios V | 2008 | J Clin Immunol2008，28，： | 1 |
| 12 | Com- petitive displacement of oil body surface proteins by Tween 80 Effect on physical stability 显示文摘 | Constantinos V Nikiforidis Vassilios Kiosseoglou | 2011 | Food Hydrocol- loids2011，25，5： | 1 |
| 13 | Aqueous extraction of oil bodies from maize germ (Zea mays) and characterization of the resulting natural oil - in - water emulsion 显示文摘 | NIKIFORIDIS C V VASSILIOS K | 2009 | J Agric Food Chem2009，57，12： | 1 |
| 14 | Sprague, the role of customer relationships in the growth of small-to medium-sized manufacturers显示文摘 | VASSILIOS P V LINDA G | 2001 | International Journal of Operations and Production Management2001，21，4： | 1 |
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