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| 1 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | Comparison of different lymph node staging systems in prognosis of gastric cancer:a bi-institutional study from Hungary显示文摘Objective: The Union for International Cancer Control(UICC) Node(N) classification is the most common used staging method for the prognosis of gastric cancer. It demands adequate, at least 16 lymph nodes(LNs) to be dissected; therefore different staging systems were invented.Methods: Between March 2005 and March 2010, 164 patients were evaluated at the Department of General Surgery in the Kenézy Gyula Hospital and at the Department of General, Thoracic and Vascular Surgery in the Kaposi Mór Hospital. The 6th, 7th and 8th UICC N-staging systems, the number of examined LNs, the number of harvested negative LNs, the metastatic lymph node ratio(MLR) and the log odds of positive LNs(LODDS) were determined to measure their 5-year survival rates and to compare them to each other.Results: The overall 5-year survival rate for all patients was 55.5% with a median overall survival time of 102 months. The tumor stage, gender, UICC N-stages, MLR and the LODDS were significant prognostic factors for the 5-year survival with univariate analysis. The 6th UICC N-stage did not follow the adequate risk in comparing N2 vs. N0 and N3 vs. N0 with multivariate investigation. Comparison of performances of the residual N classifications proved that the LODDS system was first in the prediction of prognosis during the evaluation of all patients and in cases with less than 16 harvested LNs. The MLR gave the best prognostic prediction when adequate(more than or equal to 16) lymphadenectomy was performed.Conclusions: We suggest the application of LODDS system routinely in western patients and the usage of MLR classification in cases with extended lymphadenectomy. | dezso tóth adrienn bíró zsolt varga miklós torok péterárkosy | 2017 | Chinese Journal of Cancer Research2017，29，4： | 4 |
| 3 | A novel viscosity reducer for kraft process black liquors with a high dry solids content显示文摘 | Llamas P Domingu6z T Vargas J M | 2007 | Engineering and Processing2007，46，3： | 1 |
| 4 | T cells from human allergen-induced late asthmatic responses express IL-12receptor beta2subunit mRNA and respond to IL-12in vitro显示文摘 | Varga E M Wachholz P Nouri-Aria K T | 2000 | J Immunol2000，165，5： | 1 |
| 5 | Uncertainty and Rank Order in the Analytic Hierarchy Process显示文摘 | Satty T L Vargas LG | 1987 | European Journal of Operational Research1987，，： | 1 |
| 6 | Study of humic-like substances in fog and interstitial aerosol by size-exclusion chromatography and capillary electrophoresis显示文摘 | Z Krivácsy Gy Kiss B Varga I Galambos Zs Sárvári A Gelencsér á Molnár S Fuzzi M.C Facchini S Zappoli A Andracchio T Alsberg H.C Hansson L Persson | 2000 | Atmospheric Environment2000，，25： | 1 |
| 7 | Bombesin receptor subtype mediation of gastroenteropancreatic hormone seere-tion in rats 显示文摘 | Varga G Adrian T E Coy D H | 1994 | Peptides1994，15，4： | 1 |
| 8 | Environmental factors affecting N2 fixation in grain legumes in the tropics, with an emphasis on Brazil显示文摘 | HUNGRIA M VARGAS M A T | 2000 | Field Crops Research2000，65，： | 1 |
| 9 | Visualization of network structure by the application of hypernodes显示文摘 | Bjφrke J T Nilsen S Varga M | 2010 | International Journal of Approximate Reasoning2010，51，3： | 1 |
| 10 | Environmental factors affecting N2 fixation in grain legumes in the tropics,with an emphasis on Brazil显示文摘 | Hungria M Vargas M A T | 2000 | Field Crops Res2000，65，2： | 1 |
| 11 | Oxidative stress in distant ornans and the effects of allopurinol during experimental acute pancreatitis显示文摘 | Czako L Takacs T Varga IS | 2000 | Int J Pancreatol2000，27，3： | 1 |
| 12 | Chemical and electrochemical basis of bioleaching processes 显示文摘 | HANSFORD G S VARGAS T | 2001 | Hydrometallurgy2001，59，23： | 1 |
| 13 | On the Evaluation of Unsaturated Flow in a Natural Slope in Rio de Janeiro, Brazil显示文摘 | Gerscovich D M S Vargas Jr E A Campos T M P de | 2006 | Engi- neering Geology2006，88，12： | 1 |
| 14 | Recent patents on the application of bioactive compounds in food:a short review显示文摘 | BONILLA J VARGAS F C OLIVEIRA de T G | 2015 | Food Engineering and Processing2015，，5： | 1 |
| 15 | The pathogenesis of L-arginine-induced acute necrotizing pancreatitis:inflammatory mediators and endogenous cholecystokinin显示文摘 | Czakó L Takács T Varga IS | 2000 | J Physiol Paris2000，94，1： | 1 |
| 16 | Bioleaching of refractory gold concentrates at high pulp densities in a nonconventional rotating-drum reactor 显示文摘 | HERRERA M N ESCOBAR B PARRA N GONZALEZ C VARGAS T | 1998 | Minerals and Metallurgy Processing1998，15，： | 1 |
| 17 | Diffusion-weighted MR Ima- ging: Assessment of Prostate Cancer Aggressiveness 显示文摘 | Vargas HA Akin O Franiel T | 2011 | Radiology2011，259，3： | 1 |
| 18 | Degradation of ochratoxin A by Aspergillus species显示文摘 | Varga J Rigó K Téren J | | 0，，： | 1 |
| 19 | Hyperbranched polyglycerol electrospun nanofibers for wound dressing applica tions显示文摘 | Vargas E A T Do Vale Baraeho N C De Brilo J | 2010 | Aeta biornaterialia2010，6，3： | 1 |
| 20 | Analysis of systemic and regionalprocalcitonin serum levels during liver transplantation显示文摘 | FAZAKAS J GONDOS T VARGA M | 2003 | Transpl Int2003，16，7： | 1 |
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