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| 1 | Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas显示文摘In gliomas, the canonical Wingless/Int(WNT)/b-catenin pathway is increased while peroxisome proliferator-activated receptor gamma(PPAR-c) is downregulated.The two systems act in an opposite manner. This review focuses on the interplay between WNT/b-catenin signaling and PPAR-c and their metabolic implications as potential therapeutic target in gliomas. Activation of the WNT/bcatenin pathway stimulates the transcription of genes involved in proliferation, invasion, nucleotide synthesis,tumor growth, and angiogenesis. Activation of PPAR-c agonists inhibits various signaling pathways such as the JAK/STAT, WNT/b-catenin, and PI3 K/Akt pathways,which reduces tumor growth, cell proliferation, cell invasiveness, and angiogenesis. Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin,and sulforaphane downregulate the WNT/b-catenin pathway through the upregulation of PPAR-c and thus appear to provide an interesting therapeutic approach for gliomas.Temozolomide(TMZ) is an antiangiogenic agent. The downstream action of this opposite interplay may explain the TMZ-resistance often reported in gliomas. | AlexANDre Vallée Yves Lecarpentier Rémy Guillevin Jean-Noёl Vallée | 2018 | Neuroscience Bulletin2018，34，3： | 7 |
| 2 | Pancreatic cancer: Are 'liquid biopsies' ready for prime-time?显示文摘Pancreatic cancer is a disease that carries a poor prognosis. Accurate tissue diagnosis is required. Tumours contain a high content of stromal tissue and therefore biopsies may be inconclusive. Circulating tumour cells(CTCs) have been investigated as a potential 'liquid biopsy' in several malignancies and have proven to be of prognostic value in breast, prostate and colorectal cancers. They have been detected in patients with localised and metastatic pancreatic cancer with sensitivities ranging from 38%-100% using a variety of platforms. Circulating tumour DNA(ct DNA) has also been detected in pancreas cancer with a sensitivity ranging from 26%-100% in studies across different platforms and using different genetic markers. However, there is no clear consensus on which platform is the most effective for detection, nor which genetic markers are the most useful to use. Potential roles of liquid biopsies include diagnosis, screening, guiding therapies and prognosis. The presence of CTCs or ct DNA has been shown to be of prognostic value both at diagnosis and after treatment in patients with pancreatic cancer. However, more prospective studies are required before this promising technology is ready for adoption into routine clinical practice. | Alexandra R Lewis Juan W Valle Mairead G Mc Namara | 2016 | World Journal of Gastroenterology2016，22，32： | 5 |
| 3 | Investigation of Laminated Fabric Cages Used in Rolling Bearings by ToF - SIMS 显示文摘 | Gunst U Zabel W R Valle N | 2010 | Tribology International2010，43，56： | 1 |
| 4 | Esmolol for the potentiation of nitroprusside-induced hypotension: impact on the cardiovascular adrenergic and renin-angiotensin system in man显示文摘 | EDMONDSON R DEL VALLE O SHAH N | 1989 | Anesth Analg1989，69，2： | 1 |
| 5 | Chitosan as a pore former in coated beads for colon specific drug delivery of 5-ASA显示文摘 | Omwancha WS Mallipeddi R Valle BL | 2013 | Int J Pharm2013，441，12： | 1 |
| 6 | Relation between the presence of inhibitors and deposit morphology in nickel deposition 显示文摘 | VALLéS E POLLINA R GóMEZ E | 1993 | Journal of Applied Electrochemistry1993，23，5： | 1 |
| 7 | Cinacalcet reduces the set point of the PTH calcium curve显示文摘 | Valle C Rodriguez M Santamaria R | 2008 | J Am Soc Nephrol2008，19，： | 1 |
| 8 | Skull base cephalometrie changes in cranial expansion by springs 显示文摘 | deFaria Valle Dornelles R Cardim VL de Campos Fonseca Pinto AC | 2011 | J CraniofacSurg2011，22，： | 1 |
| 9 | Kullback Leibler divergence measure for multivariate skewnormal distributions显示文摘 | Contreras Reyes J E Arellano Valle R B | 2012 | Entropy2012，14，： | 1 |
| 10 | Optimization of an equilibrium modified atmosphere packaging(Emap)for minimally processed mandarin segments显示文摘 | Valle V Hernández-Mu?oz P Catalá R | | 0，，03： | 1 |
| 11 | Low-grade systemic inflammation, hypoadiponectinemia and a high concentration of leptin are present in very young obese children, and correlate with metabolic syndrome 显示文摘 | Valle M Martos R Gascon F | 2005 | Diabetes Metab2005，31，： | 1 |
| 12 | Surgery guided by 5-aminolevulinic fluorescence in glioblastoma:volumetric analysis of extent of resection in single-center experience 显示文摘 | Diez Valle R Tejada Solis S Idoate Gastearena MA | 2011 | J Neurooncol2011，102，1： | 1 |
| 13 | Reverse logistic in the Brazilian construction industry显示文摘 | K R A Nunes C F Mahler R A Valle | 2009 | Joumal of Environmental Management2009，，90： | 1 |
| 14 | Hyperhomocysteinemia correlates with insulin resistance and low-grade systemic inflammation in obese prepubertal children 显示文摘 | Martos R Valle M Morales R | 2006 | Metabolism2006，55，： | 1 |
| 15 | Unexpected gallbladder cancer after laparoscopic cholecystectomy:an emerging problem?Reflections on four cases显示文摘 | Contini S Dalla Valle R Zinicola R | 1999 | Surg Endosc1999，13，3： | 1 |
| 16 | B-type natriuretic peptide can predict the medium-term risk in patients with acute heart failure and preserved systolic function显示文摘 | Valle R Aspromonte N Feola M | 2005 | J Card Fail2005，11，7： | 1 |
| 17 | Could HRM sup- port organizational innovation 显示文摘 | Jimenez- Jimenez D Sanz -Valle R | 2008 | International Journal Of Human Resource Management2008，19，7： | 1 |
| 18 | An identikit of patients seeking treatment for erectile dysfunction in Italy:results from the EDOS Italian database显示文摘 | FUSCO F SICUTERI R VALLE D | 2007 | Arch Ital Urol Androl2007，79，1： | 1 |
| 19 | Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats显示文摘 | Duarte J Jimenez R O' Valle F | 2002 | J Hypertens2002，20，9： | 1 |
| 20 | Relationship between high plasma leptin concentration and metabolic syndrome in obese pre-pubertal chilren显示文摘 | Valle M Gascon F Martos R | | 0，，01： | 1 |
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