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| 1 | Non-pharmacological cognitive intervention for aging and dementia:Current perspectives显示文摘In recent years, cognitive difficulties associated with normal aging and dementia have been receiving increased attention from both public and scientific communities. With an increase in overall lifespan, promoting healthy cognition has become a priority and a necessity for minimizing and preventing individual and societal burdens associated with cognitive dysfunctions in the elderly. The general awareness concerning the efficacy of preventive(e.g., lifestyles) and palliative treatment strategies of cognitive impairments, related to either healthy or unhealthy trajectories in cognitive aging, is continuously rising. There are several therapeutic strategies which can be broadly classified as either pharmacological or non-pharmacological/psychosocial. In face of the modest evidence for success of pharmacological treatments, especially for dementia related impairments, psychosocial interventions are progressively considered as a complementary treatment. Despite the relative spread of psychosocial interventions in clinical settings, research in this area is rather scarce with evidence for success of these therapies remaining controversial. In this work we provide an evidence based perspective on cognitive intervention(s) for healthy aging, pre-dementia(mild cognitive impairment), and dementia populations. Current evidence and future directions for improving cognitive functions in the elderly are discussed as well. | Jorge Alves Rosana Magalh?es álvaro Machado óscar F Gon?alves Adriana Sampaio Agavni Petrosyan | 2013 | World Journal of Clinical Cases2013，1，8： | 8 |
| 2 | Towards curative therapy in gastric cancer:Faraway, so close!显示文摘Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer(GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments. | Marília Cravo Catarina Fidalgo Rita Garrido Tania Rodrigues Gon?alo Luz Carolina Palmela Marta Santos Fábio Lopes Rui Maio | 2015 | World Journal of Gastroenterology2015，21，41： | 2 |
| 3 | Quantitative analyses of kidney injury molecule -1messenger RNA in kidney transplant recipients with graft dysfunc-tion显示文摘 | Nogare A L Joelsons G Pedroso J A Veronese F J Gonalves L F Manfro R C | 2010 | Transplant Proc2010，42，： | 1 |
| 4 | Identification and characterization of MtMTP1,a Zn transporter of CDF family,in the Medicago truncatula显示文摘 | CHEN M L SHEN X Y LI D F MA L GON J L WANG T | 2009 | Plant Physiology and Biochemistry2009，47，： | 1 |
| 5 | NOD2/CARD15 and TNFA, but not IL1B and IL1RN, are associated with Crohn’s disease显示文摘 | António CarlosFerreira SusanaAlmeida MartaTavares PauloCanedo FábioPereira Gon?aloRegalo CéuFigueiredo EuniceTrindade RaquelSeruca FátimaCarneiro JorgeAmil José CarlosMachado FernandoTavarela‐Veloso | 2006 | Inflamm Bowel Dis2006，，4： | 1 |
| 6 | Hyperglycaemia at admission in acute coronary syndrome patients:prognostic value in diabetics and non-diabetics显示文摘 | Monteiro S Monteiro P Gon?alves F | | 0，，： | 1 |
| 7 | Gait in elderly with cerebral small vessel disease显示文摘 | de Laat K F van Norden A G Gons R A | | 0，，08： | 1 |
| 8 | Diamondoid and biomarker characterization of oils from the Llanos Orientales Basin, Colombia 显示文摘 | SPRINGER M V GARCIA D E GON(ALVES F T T | 2010 | Organic Geochemistry2010，41，9： | 1 |
| 9 | Postoperative serum proteomic profiles may predict metastatic relapse in high-risk primary breast cancer patients receiving adjuvant chemotherapy显示文摘 | Gonalves A Esterni B Bertucci F | 2006 | Oncogene2006，25，7： | 1 |
| 10 | Cerebral white matter lesions and lacunar infarcts contribute to the presence of mild parkinsonian signs显示文摘 | de Laat K F van Norden A G Gons R A | | 0，，10： | 1 |
| 11 | Assessing arsenic, cadmium, and lead contents in major crops in Brazil for food safety purposes显示文摘 | Ana Paula Branco Corguinha Guilherme Amaral de Souza Veridiana Cardoso Gon?alves Camila de Andrade Carvalho Willian Eduardo Amaral de Lima Fábio Aurélio Dias Martins Celso Hideto Yamanaka Eros Artur Bohac Francisco Luiz Roberto Guimar?es Guilherme | 2014 | Journal of Food Composition and Analysis2014，，： | 1 |
| 12 | Morphology Control in Block Copolymer Films Using Mixed Solvent Vapors显示文摘 | Kevin W Gotrik Adam F Hannon Jeong Gon Son | 2012 | Acsnano2012，6，9： | 1 |
| 13 | Levosimendan is efficacious in acute heart failure independent of renal function显示文摘 | Franco F Gon?alves F Castro G | 2003 | Eur Heart J2003，，： | 1 |
| 14 | Postharvestcontrol of brown rot and Rhizopus rot in plums and nectarines using carnaubawax显示文摘 | GON?ALVES F P MARTINS M C Jr SILVA G J | 2010 | Postharvest Biology and Technology2010，58，： | 1 |
| 15 | Membrane binding sites and non-genomic effects of estrogen in cultured human pre-osteoclatic cells显示文摘 | Fiorelli G Gon F Frediani U | 1996 | J Stroid Biochem Mol Biol1996，59，： | 1 |
| 16 | An evolutionary approach to complex schema matching显示文摘 | De Carvalho M S G Laender A H F Gonalves M A | 2013 | Information Systems2013，38，3： | 1 |
| 17 | Community-level effects in edaphic fauna from an abandoned mining area: Integration with chemical and toxicological lines of evidence 显示文摘 | Antunes SC Castro BB Moreira C Gon?alves F Pereira R | 2013 | Ecotoxicol Environ Saf2013，88，1： | 1 |
| 18 | Prevalence of mental disorders at a referral center for the Family Health Program in Santa Cruz do Sul,Rio Grande do Sul State,Brazil显示文摘 | Gon(c)alves DM Kapczinski F | 2008 | Cad Saude Publica2008，24，9： | 1 |
| 19 | An evolutionary approach to complex schema matching显示文摘 | De Carvalho M S G Laender A H F Gonalves M A | 2013 | Information Systems2013，38，3： | 1 |
| 20 | Locally advanced and metastatic prostate cancer treated with intermittent androgen monotherapy or maximal androgen blockade:results from a randomised phase 3study by the South European Uroncological Group显示文摘 | Calais da Silva F Calais da Silva F M Gonalves F | 2014 | Eur Urol2014，66，2： | 1 |
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