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| 1 | Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex显示文摘在发炎和白血球过多症之间的潜在的交叉连接有一段时间被讨论了,但是支持这教义的试验性的证据是少见的。特别地,由煽动性的调停人理解为 proto-oncogenic 生长因素表情的潜在的 upregulation 负责的机制是重要的。这里,我们调查了高度煽动性的 cytokine interleukin-1 贝它的能力(IL-1β) 到导致干细胞因素(SCF ) 的生产,它是在造血的 myeloid 细胞的恶意的转变之上控制尖锐 myeloid 白血球过多症的前进的一个主要造血的生长因素。我们发现了那人的 IL-1β在 MCF-7 人的上皮的乳癌房间和那导致了 SCF 的表示 / 分泌物这个过程取决于组织缺氧可诱导的因素 1 (HIF-1 ) 抄写建筑群。我们也表明了 phosphatidylinositol-3 kinase (PI-3K ) 的一个关键角色 rapamycin (mTOR ) 的 /mammalian 目标在 IL-1β 的小径;导致的 HIF-1α在 MCF-7 房间的累积。重要地, mTOR 也被发现在 IL-1β 起一个作用;导致的 SCF 生产。而且,为 IL-1β 的积极关联的一个趋势;并且在健康人的施主的血浆的 SCF 层次被观察。总的来说,我们的结果表明那 IL-1β,它通常衔接天生、适应的免疫,通过 PI-3K/mTOR 小径和 HIF-1 抄写建筑群导致主要 haematopoietic/proleukaemic 生长因素 SCF 的生产。这些调查结果强烈支持在发炎和尖锐 myeloid 白血球过多症之间的串音。 | Rafal W Wyszynski Bernhard F Gibbs Luca Varani Daniela Iannotta Vadim V Sumbayev | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 2 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 3 | Fluorescence waveforms and coupled energy levels in Er3+:ZBLAN 显示文摘 | Bogdanov V K Booth D J Gibbs W E K | 2002 | Non-Crystalline Solids2002，311，： | 2 |
| 4 | Evaluation of Culi eoides insignisiptera:Ceratopogonida as a vector of bluetongue virus显示文摘 | Tanya V N Greiner E G Gibbs E P | | 0，，： | 1 |
| 5 | The crystal structure of synthetic titanite CaTiOSiO4 and the domain textures of natural titanites显示文摘 | Speer J A Gibbs G V | 1976 | American Mineralogist1976，61，： | 1 |
| 6 | Stem-like cells in bone sarcomas: implications for tumorigenesis显示文摘 | Gibbs C P Kukekov V G Reith J D Tchigrinova O Suslov O N Scott E W | 2005 | Neoplasia2005，7，： | 1 |
| 7 | Interactive software for calculating and displaying X-ray or neutron powder diffractometer patterns of crystalline materials 显示文摘 | Downs R T Bartelmehs K L Gibbs G V | 1993 | American Mineralogist1993，78，910： | 1 |
| 8 | Extent of mesorectal spread and involvement of lateral resection margin as prognostic factors after surgery for rectal cancer显示文摘 | CAWTHORN S J PARUMS D V GIBBS N M | 1990 | Lancet1990，335，： | 1 |
| 9 | Total mesenteric excision in the treatment of rectal carcinoma:methods and outcomes显示文摘 | Brennan T V Lipshutz G S Gibbs V C | 2002 | Surg Oncol2002，10，4： | 1 |
| 10 | Mechanism of ozonedecomposition on a manganese oxide catalyst(Ⅰ):Insitu Raman spectroscopy and ab initio molecular orbitalcalculations显示文摘 | Li W Gibbs G V Oyama S T | 1998 | Jounal of the American ChemicalSociety1998，120，35： | 1 |
| 11 | The Crystal Structure of Synthetic Titanite CaTiOSiO4 and the Domain Textures of Natural Ttitanites显示文摘 | Speer J A Gibbs G V | 1976 | American Mineralogist1976，61，： | 1 |
| 12 | Antigenic and genetic characterization of a novel hemagglutinin subtype of influenza A viruses from gulls显示文摘 | Hinshaw V S G M Air A J Gibbs | 1982 | Viro1982，42，： | 1 |
| 13 | Power law relationships between bond length, bond strength and electron density distributions 显示文摘 | Gibbs G V Hill F C Boisen M B | 1998 | Phys Chem Miner1998，25，： | 1 |
| 14 | Expression of xylanase enzymes from thermophilic microorganisms in fungal hosts显示文摘 | Bergquist P Teo V Gibbs M | 2002 | Extremophiles2002，6，： | 1 |
| 15 | Molecular mimicry of the bond-length-bond- strength variations in oxide crystals 显示文摘 | Gibbs G V Finger L W Boisen M B | 1987 | Phys Chem Miner1987，14，： | 1 |
| 16 | Lion - Human con- flict in the gir forest, India 显示文摘 | Saberwal V K Gibbs J P Chellam R | 1994 | Conservation Biology1994，8，2： | 1 |
| 17 | A physical basis for Pauling's definition of bond strength 显示文摘 | Gibbs G V Rosso K M Cox D F | 2003 | Phys Chem Miner2003，30，： | 1 |
| 18 | Isolation and aticoagulant pro-pertiec of polysaccharides of typha angustata and dae monorops species显示文摘 | Gibbs A Greec E Doctor V M | 1983 | Thromb Res1983，32，2： | 1 |
| 19 | Docking: successes and challenges显示文摘 | Mohan V Gibbs A C Cummings M D | 2005 | Curr Pharm Des2005，11，3： | 1 |
| 20 | Characterization of human recombinant interleukin-2 binding to heparin and heparan sulfate using an ELISA approach 显示文摘 | NAJJAM S R V GIBBS RIDER C C | 1997 | Cytokine1997，9，12： | 1 |
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