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| 1 | Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10)显示文摘Tolerogenic dendritic cells(DCs)are key players in maintaining immunological homeostasis,dampening immune responses,and promoting tolerance.DC-10,a tolerogenic population of human IL-10-producing DCs characterized by the expression of HLA-G and ILT4,play a pivotal role in promoting tolerance via T regulatory type 1(Tr1)cells.Thus far,the absence of markers that uniquely identify DC-10 has limited in vivo studies.By in vitro gene expression profiling of differentiated human DCs,we identified CD141 and CD163 as surface markers for DC-10.The coexpression of CD141 and CD163 in combination with CD14 and CD16 enables the ex vivo isolation of DC-10 from the peripheral blood.CD14+CD16+CD141+CD163+cells isolated from the peripheral blood of healthy subjects(ex vivo DC-10)produced spontaneously and upon activation of IL-10 and limited levels of IL-12.Moreover,in vitro stimulation of allogeneic naive CD4+T cells with ex vivo DC-10 induced the differentiation of alloantigen-specific CD49b+LAG-3+Tr1 cells.Finally,ex vivo DC-10 and in vitro generated DC-10 exhibited a similar transcriptional profile,which are characterized by an anti-inflammatory and pro-tolerogenic signature.These results provide new insights into the phenotype and molecular signature of DC-10 and highlight the tolerogenic properties of circulating DC-10.These findings open the opportunity to track DC-10 in vivo and to define their role in physiological and pathological settings. | Michela Comi Daniele Avancini Francesca Santoni de Sio Matteo Villa Molly Javier Uyeda Matteo Floris Daniela Tomasoni Alessandro Bulfone Maria Grazia Roncarolo Silvia Gregori | 2020 | Cellular & Molecular Immunology2020，17，1： | 4 |
| 2 | 日本超低频地磁场测量及关于1998年Iwateken Nairiku Hokubu地震的近期研究成果显示文摘过去对Spitak,Loma Prieta和Guam地震的研究表明,大地震发生之前都会有相应的磁场异常。为了确认这一事实并详细研究超低频(ULF)现象,日本建立了一个超低频磁力仪的监测网络,开展了包括小型台阵在内的网络观测工作。文中同时介绍了在Matsukawa台站观测到的与Iwateken Nairiku Hokubu地震(震级M6.1级,发生在1998年9月3日,震源深度为10 km)相关的地磁资料。分析了4.5年的资料,并对获得的结果进行了讨论。在地震前两个星期,水平和垂直分量之间的谱密度比的(极化)变化表现出异常情况。这是在相当长的数据分析中发现的一次独特的变化,它暗示了这种异常变化可能是大地震孕育期间的一个信号。 | K. Hattori I. Takahashi C. Yoshino N. Isezaki H. Iwasaki M. Harada K. Kawabata E. Kopytenko Y. Kopytenko P. Maltsev V. Korepanov O. Molchanov M. Hayakawa Y. Noda T. Nagao S. Uyeda 张素琴 | 2005 | 国际地震动态2005，，11： | 2 |
| 3 | Cell adhesion molecules regulate contractile ring-indepen- dent cytokinesis in Dictyostelium discoideum显示文摘在胞质分裂调查底层粘附的角色,我们建立了房间线缺乏 paxillin (PAXB ) 或 vinculin (七弦琴) ,和在 Dictyostelium discoideum 表示各自的 GFP 熔化蛋白质的那些。作为在哺乳动物的房间, GFP-PAXB 和 GFP 七弦琴在房间底部上形成了焦点的像粘附的建筑群。paxB?在暂停的房间通常,但是上种了底层,经常没能在沟的回归以后划分。paxB 的有效胞质分裂?在暂停的房间不因为砍帮助截去,,的力量他们也在静态的暂停文化通常划分了。双猛烈紧张缺乏 mhcA,它为肌浆球蛋白 II 编码,和 paxB 或七弦琴比各单个的大美人显示了更严重的 cytokinetic 缺点紧张。在有丝分裂的野类型的房间, GFP-PAXB 广泛地在基础膜上被散布,但是惊人地在有丝分裂的 mhcA 沿着极的边被压缩吗?房间。这些结果与我们 Dictyostelium 显示胞质分裂的二种形式的想法一致,是可收缩的戒指依赖者的并且粘附无关,并且可收缩的其它戒指无关并且粘附依赖者,并且后者要求 PAXB 和七弦琴。而且,那 paxB?房间没能面对底层粘附通常划分建议这个粘附分子可以起另外的发信号的作用。 | Akira Nagasaki Masamitsu Kanada Taro QP Uyeda | 2009 | Cell Research2009，19，2： | 2 |
| 4 | Automatic Detection of Gust Fronts显示文摘 | Hiroshi Uyeda Dusan S Zrnic | 1986 | J Atmos Oceanic Technol1986，3，： | 1 |
| 5 | Carbohydrate response element binding protein,ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis显示文摘 | Uyeda K Repa J J | 2006 | Cell Metab2006，4，2： | 1 |
| 6 | Synthesis of compact multi dentate ligands to prepare stable hydrophilic quantum dot fluorophores显示文摘 | Uyeda H T Medintz I L | 2005 | J Am Chem Soc2005，127，： | 1 |
| 7 | Nucleotide sequence of rice black-streaked dwarf virus genome segment 10 显示文摘 | UYEDA I AZUHATA F SHIKATA E | 1990 | Proc Jpn Acad Ser B1990，66，2： | 1 |
| 8 | Regulation of growth plate chondrogenesis by bone morphogenetic protein-2显示文摘 | Barnes KM Uyeda JA | 2001 | Endocrinology2001，142，1： | 1 |
| 9 | Formation of Ultrafine Metal Partiles by Gas-evaparation显示文摘 | Mihama K Uyeda R | 1980 | Appl Phys1980，19，9： | 1 |
| 10 | Studies of ultrafine particles in Japan:Crystallography,methods of preparation and technological application显示文摘 | UYEDA R | 1991 | Prog in Mater Sci1991，35，： | 1 |
| 11 | Catalyt- ic enantioselective claisen rearrangments of O-Allyl /-Ketoesters显示文摘 | UYEDA C ROTHELI A R JACOBSEN E N | 2010 | Angew Chem Int Ed2010，49，50： | 1 |
| 12 | Effect of culture time on the basal expression levelsof drug transporters in sandwich-cultured primaryrat hepatocytes 显示文摘 | Tchaparian EH Houghton JS Uyeda C | 2011 | Drug Metab Dispos2011，39，12： | 1 |
| 13 | Quantum dot bioconjugates fofimaging, labelling and sensing 显示文摘 | Medintz I L Uyeda H T Goldman E R | 2005 | Nature Materials2005，，6： | 1 |
| 14 | Regulationof growth platechondrogenesis by bone morphogenetic protein-2显示文摘 | De-Luca F Barnes KM Uyeda JA | 2001 | Endocrinology2001，，1： | 1 |
| 15 | Electric and magnetic phenomena observed before the volcano-seismic activity in 2000 in the Izu Island Region, Japan 显示文摘 | Uyeda S | 2002 | PNAS2002，99，： | 1 |
| 16 | 查看详情显示文摘 | Medintz I.L Uyeda H.T Goldman E.R Mattoussi H | | 0，，： | 1 |
| 17 | Integration of 64 de teetor lower extremity CT angiography into whole body trauma imaging: feasibility and early experience显示文摘 | Foster BR Anderson SW Uyeda JW | 2011 | Radiology2011，261，3： | 1 |
| 18 | Quantum dot bioconjugates for imaging,labelling and sensing显示文摘 | Medintz IL Uyeda HT Goldman ER | 2005 | Nat Mater2005，4，6： | 1 |
| 19 | Enhancing the Stability and Biological Functionalities of Qaantum Dots Via Compact Multifunctional Ligands显示文摘 | Susumu K Uyeda H T Medintz I L | 2007 | Journal of the American Chemical Society2007，129，45： | 1 |
| 20 | Visualizing myosin-actin in- teraction with a genetically-encoded fluorescent strain sensor显示文摘 | IWAI S UYEDA T Q P | 2010 | Proceedings of the National Academy of Sciences of the United States of America2010，105，16： | 1 |
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