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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Accumulation and crop uptake of soil mineral nitrogen as influenced by tillage,cover crops,and nitrogen fertilization显示文摘 | Upendra M S Bharat P S Wayne F W | 2007 | Agronomy Journal2007，99，： | 1 |
| 3 | Carbon and nitrogen pools in soil aggregates ~eparated by dry and wet sieving methods显示文摘 | Sainju Upendra M | 2006 | Soil Science2006，171，12： | 1 |
| 4 | Ultrafine metal particle formation in reverse micellar systems: effects of intermicellar exchange on the formation of particles显示文摘 | Upendra N Kalyan H Anurag M | 1996 | Langmuir1996，12，： | 1 |
| 5 | Soil Carbon Dioxide Emission and Carbon Content as Affected by Irrigation, Tillage, Cropping System, and Nitrogen Fertilization显示文摘 | Sainju Upendra M Jabro Jalal D Stevens William B | 2008 | Journal of Environmental Quality2008，，1： | 1 |
| 6 | Tillage, Cropping Systems, and Nitrogen Fertilizer Source Effects on Soil Carbon Sequestration and Fractions显示文摘 | Sainju Upendra M Senwo Zachary N Nyakatawa Ermson Z Tazisong Irenus A Reddy K Chandra | 2008 | Journal of Environmental Quality2008，，3： | 1 |
| 7 | Dryland plant biomass and soil carbon and nitrogen fractions on transient land as influenced by tillage and crop rotation显示文摘 | Sainju U M Upendra M Thecan C T | 2007 | Soil and Tillage Research2007，93，2： | 1 |
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