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| 1 | Promoting genetics in non-alcoholic fatty liver disease: Combined risk score through polymorphisms and clinical variables显示文摘Non-alcoholic fatty liver disease(NAFLD) has a prevalence of approximately 30% in western countries, and is emerging as the first cause of liver cirrhosis and hepatocellular carcinoma(HCC). Therefore, risk stratification emerges as fundamental in order to optimize human and economic resources, and genetics displays intrinsic characteristics suitable to fulfill this task. According to the available data, heritability estimates for hepatic fat content range from 20% to 70%, and an almost 80% of shared heritability has been found between hepatic fat content and fibrosis. The rs738409 single nucleotide polymorphism(SNP) in patatin-like phospholipase domain-containing protein 3 gene and the rs58542926 SNP in transmembrane 6 superfamily member 2 gene have been robustly associated with NAFLD and with its progression, but promising results have been obtained with many other SNPs. Moreover, there has been proof of the additive role of the different SNPs in determining liver damage, and there have been preliminary experiences in which risk scores created through a few genetic variants, alone or in combination with clinical variables, were associated with a strongly potentiated risk of NAFLD, non-alcoholic steatohepatitis(NASH), NASH fibrosis or NAFLD-HCC. However, to date, clinical translation of genetics in the field of NAFLD has been poor or absent. Fortunately, the research we have done seems to have placed us on the right path: We should rely on longitudinal rather than on cross-sectional studies; we should focus on relevant outcomes rather than on simple liver fat accumulation; and we should put together the genetic and clinical information. The hope is that combined genetic/clinical scores, derived from longitudinal studies and built on a few strong genetic variants and relevant clinical variables, will reach a significant predictive power, such as to have clinical utility for risk stratification at the single patient level and even to esteem the impact of intervention on the risk of disease-related outcomes. Well-structured future studies would demonstrate if this vision can become a reality. | Umberto Vespasiani-Gentilucci Paolo Gallo Chiara Dell' Unto Mara Volpentesta Raffaele Antonelli-Incalzi Antonio Picardi | 2018 | World Journal of Gastroenterology2018，24，43： | 2 |
| 2 | Validity and eliability of Resource Utilization Groups(RUG-Ⅲ )in finnish long-term care facilities显示文摘 | Magnus AB Unto H Harriet U | 1999 | Scand J Public Health1999，27，： | 1 |
| 3 | Measuring cost efficiency in the Nordic Hospitals-a cross-sectional comparison of public hospitals in 2002 显示文摘 | Miika Linna Unto Hakkinen Mikko Pehola | 2010 | Health Care Manag Sci2010，13，4： | 1 |
| 4 | Thyroid colorflow Doppler sonography and radio iodine up take in 55 consecutive patients with amiodarone-indouced thyrotoxicosis显示文摘 | Bogazzi F Martino E Dell'Unto E | 2003 | J Endo- crine Invest2003，26，7： | 1 |
| 5 | in press,'Archeological excavation monitoring using dense stereo matching techniques显示文摘 | Dellepiane M Dell' Unto N Callieri M Lindgren S Scopigno R | | 0，，： | 1 |
| 6 | Aging, health expenditure, proximity to death, and income in Finland显示文摘 | UNTO HAKKINEN PEKKA MARTIKAINEN ANJA NORO MIKKO PELTOLA | 2008 | Health Economies Policy and Law2008，，3： | 1 |
| 7 | Splitting the unit delay:Tools for fractional delay filter design显示文摘 | Laakso TIMO I Valimaki Vesa Karjalainen Matti Laine Unto K | 1996 | IEEE Signal Processing Mag1996，，13： | 1 |
| 8 | HCV carriers with normal alanine aminotransferase levels: Healthy persons or severely ill patients?显示文摘 | Claudio Puoti Lia Bellis Riccardo Guarisco Orlando Dell’ Unto Lucia Spilabotti Olga Mitidieri Costanza | 2009 | European Journal of Internal Medicine2009，，： | 1 |
| 9 | Malignant giant cell tumor of the tendon sheaths and joints(malignant pigmented villouodular synovitis)显示文摘 | Bertoni F Unto KK Beabout JW | 1997 | Am J surg Pathol1997，21，2： | 1 |
| 10 | Cigarette smoking and treatment outcomes in Graves ' ophthalmopathy显示文摘 | Bartalena L Marcocci C Tanda M L Manetti L Dell' Unto E Bartolomei M P | 1998 | Ann Intern Med1998，129，： | 1 |
| 11 | Splitting The Unit Delay-Tools For Fractional Delay Filter Design显示文摘 | Timo I Vesa m Unto K | 1996 | IEEE Signal Processing Magazine1996，13，1： | 1 |
| 12 | Thyroid color flow Doppler sonography and radioiodine up-take in 55 consecutive patients with amiodarone-induced thyrotoxicosis显示文摘 | Bogazzi F Martino E Dell'Unto E | 2003 | J Endocrinol Invest2003，26，： | 1 |
| 13 | Relation between therapy for hyperthyroidism and the course of Graves ophthalmopathy显示文摘 | Bartalena L Marcoeci C Bogazzi F Manetti L Tanda M L Dell'Unto E | 1998 | N Engl J Med1998，338，： | 1 |
| 14 | Proportion of type 1 and type 2 amiodarone-induced thyrotoxicosis has changed over a 27-year period in Italy显示文摘 | Bogazzi F Bartalena L Dell'Unto E | 2007 | Clin Endocrinol(Oxf)2007，67，4： | 1 |
| 15 | Long-term outcome of thyroid function after amiodarone-induced thyrotoxicosis,as compared to subacute thyroiditis显示文摘 | Bogazzi F Dell'Unto E Tanda ML | 2006 | J Endocrinol Invest2006，29，8： | 1 |
| 16 | Maize yield and physical-chemical fertility mapping for the management of the soil 显示文摘 | Servadio P Bergonzoli S Dell' Unto D | 2011 | Journal of Information Technology in Agriculture2011，4，1： | 1 |
| 17 | 芬兰百分百显示文摘芬兰SAANA JA OLLI的包袋、桌布以及抱枕上的图案,都充满了北欧自然和人文风情,让人感觉到人与自然的亲近。不但设计的灵感来自芬兰的自然生活和人文传统,这些作品从设计,印花,到缝制,产品也全部在芬兰制作完成。 | msright Saana ja Olli Unto Rautio | 2014 | 设计2014，27，5： | 0 |
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