|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 单核细胞产生IL-1、IL-6和肿瘤坏死因子的动态观察显示文摘采用生物活性测定法和免疫细胞化学染色法.观察了内毒素诱导正常人单核细胞产生白细胞介素(?).白细胞介素6和肿瘤环死因子的动态过程.以及彼此之间的相互关系。结果表明,三种细胞因子的胞浆内累积和释放均有各自不同的时相变化.反映出这三种细胞因子基因活化、转录、翻译和释放过程的差异.此外.仅部分单核细胞合成这三种细胞因子. | 王明海 何南洋 Hans-Dieter Flad Artur J Ulmer | 1990 | 中国免疫学杂志1990，6，6： | 16 |
| 2 | Grade of donor liver microvesicular steatosis does not affect the postoperative outcome after liver transplantation显示文摘BACKGROUND:The potential effect of graft steatosis on the postoperative liver function is discussed controversially. The present study aimed to evaluate the effect of the donor liver microvesicular steatosis on the postoperative outcome after liver transplantation.METHODS:Ninety-four patients undergoing liver transplantation at the University Hospital Aachen were included in this study. The patient cohort was divided into three groups according to the grade of microvesicular steatosis(MiS):MiS <30%(n=27), MiS 30%-60%(n=41) and MiS >60%(n=26).The outcomes after liver transplantation were evaluated, including the 30-day and 1-year patient and graft survival rates and the incidences of early allograft dysfunction(EAD) and primary nonfunction(PNF). RESULTS:The incidences of EAD and PNF did not differ significantly between the groups. We observed 5 cases of PNF,one occurred in the MiS <30% group and 4 in the MiS 30%-60% group. The 30-day and 1-year graft survivals did not differ significantly between groups. The 30-day patient survival rates were 100% in all groups. The 1-year patient survival rates were 94.4% in the MiS <30% group, 87.9% in the MiS 30%-60% group and 90.9% in the MiS >60% group.CONCLUSION:Microvesicular steatosis of donor livers has no negative effect on the postoperative outcome after liver transplantation. | Anne Andert Tom Florian Ulmer Wenzel Schoning Daniela Kroy Marc Hein Patrick Hamid Alizai Christoph Heidenhain Ulf Neumann Maximilian Schmeding | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，6： | 7 |
| 3 | Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients显示文摘Background: Hepatocellular carcinoma is the most common innate liver tumor. Due to improved surgical techniques, even extended resections are feasible, and more patients can be treated with curative intent. As the liver is the central metabolic organ, preoperative metabolic assessment is crucial for risk stratification. Sarcopenia, obesity and sarcopenic obesity characterize body composition and metabolic status. Here we present the impact of body composition on survival after liver resection in patients with hepatocellular carcinoma. Methods: A retrospective database analysis of 70 patients who were assigned for liver resection due to hepatocellular carcinoma was conducted. For assessment of sarcopenia and obesity, skeletal muscle surface area was measured at lumbar vertebra 3 level(L3) in preoperative four-phase contrast enhanced abdominal CT scans, and L3 muscle index and body fat percentage were calculated. Results: Univariate analysis comparing the survival curves using the score test demonstrated superior postoperative overall survival for sarcopenic( P = 0.035) and sarcopenic obese( P = 0.048) patients as well as a trend favoring obese( P = 0.130) subjects. Whereas multivariate analysis could not identify significant difference in postoperative survival regarding sarcopenia, obesity or sarcopenic obesity. Only large tumor size, multifocal disease and male gender were risk factors for long-term survival. Conclusions: Sarcopenia, obesity and sarcopenic obesity are indeed no risk factors for poor postoperative survival in this study. Our data do not support the evaluation of sarcopenia, obesity and sarcopenic obesity before liver resection in hepatocellular carcinoma patients. | Andreas Kroh Diane Uschner Toine Lodewick Roman M Eickhoff Wenzel Sch?ning Florian T Ulmer Ulf P Neumann Marcel Binneb?sel | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，1： | 5 |
| 4 | Intraoperative perfusion magnetic resonance imaging: Cutting-edge improvement in neurosurgical procedures显示文摘The goal in brain tumor surgery is to remove the maxi-mum achievable amount of the tumor, preventing damage to 'eloquent' brain regions as the amount of brain tumor resection is one of the prognostic factors for time to tumor progression and median survival. To achieve this goal, a variety of technical advances have been in-troduced, including an operating microscope in the late 1950 s, computer-assisted devices for surgical navigation and more recently, intraoperative imaging to incorporate and correct for brain shift during the resection of the lesion. However, surgically induced contrast enhancement along the rim of the resection cavity hampers interpretation of these intraoperatively acquired magnetic resonance images. To overcome this uncertainty, perfusion techniques [dynamic contrast enhanced magnetic resonance imaging(DCE-MRI), dynamic susceptibility contrast magnetic resonance imaging(DSC-MRI)] have been introduced that can differentiate residual tumor from surgically induced changes at the rim of the resec-tion cavity and thus overcome this remaining uncer-tainty of intraoperative MRI in high grade brain tumor resection. | Stephan Ulmer | 2014 | World Journal of Radiology2014，6，8： | 3 |
| 5 | 初级运动皮质:健康志愿者被动成像的fMRI效用的初步结果显示文摘目的采用BOLD—fMRI评价肢体主动和被动运动时初级运动皮质激活的一致性。方法本研究得到了当地伦理委员会的批准,所有参加本研究的志愿者均签署知情同意书。在11名健康志愿者(4名女性,7名男性,年龄范围24~42岁)手、肘、肩、踝、膝及髋进行主动和被动运动过程中进行fMRI检查。采集的数据叠加到三维解剖影像上。采用交叉相关分析,阈值在0.4水平(P〈0.01)的基础上分析激活的容积。根据解剖学标准,感兴趣区放置在中央前后回。 | M. Kocak J.L. Ulmer M. Sahin Ugurel W. Gaggl R. W. Prost 夏爽(译) 祁吉(校) | 2009 | 国际医学放射学杂志2009，32，4： | 3 |
| 6 | Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats显示文摘BACKGROUND: Post-hepatectomy liver failure as a result of insufficient liver remnant is a feared complication in liver surgery. Efforts have been made to find new strategies to support liver regeneration. The aim of this study was to investigate the effects of terlipressin versus splenectomy on postoperative liver function and liver regeneration in rats undergoing 70%partial hepatectomy. METHODS: Seventy-two male Wistar rats were randomly assigned into three groups(n=24 in each group): 70% partial hepatectomy as control(PHC), 70% partial hepatectomy with splenectomy(PHS) or 70% partial hepatectomy with a micropump for terlipressin administration(PHT). Eight rats in each group were sacrificed on postoperative day(POD) 1,3 and 7. To assess liver regeneration, immunohistochemical analysis of liver tissue using bromodeoxyuridine(BrdU) and Ki-67 labeling was performed. Portal venous pressure, serum concentrations of creatinine, urea, albumin, bilirubin and prothrombin time as well as liver-, body-weight and their ratio were determined on POD 1, 3 and 7.RESULTS: The liver-, body-weight and their ratio were not statistically different among the groups. On POD 1, 3 and 7 portal venous pressure in the intervention groups(PHT:8.13 ±1.55, 10.38±1.30, 6.25±0.89 cm H_2O and PHS: 7.50±0.93,8.88 ±2.42, 5.75±1.04 cm H_2O) was lower compared to the control group(PHC: 8.63±2.06, 10.50±2.45, 6.50±2.67 cmH_2O). Hepatocyte proliferation in the intervention groups was delayed, especially after splenectomy on POD 1(Brd U: PHS vs PHC, 20.85% ±13.05% vs 28.11%±10.10%; Ki-67, 20.14%±14.10% vs 23.96% ±11.69%). However, none of the differences were statistically significant.CONCLUSIONS: Neither the administration of terlipressin nor splenectomy improved liver regeneration after 70% partial hepatectomy in rats. Further studies assessing the regulation of portal venous pressure as well as extended hepatectomy animal models and liver function tests will help to further investigate mechanisms of liver regeneration. | Tom Florian Ulmer Anne Weiland Georg Lurje Christian Klink Anne Andert Hamid Alizai Christoph Heidenhain Ulf Neumann | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，5： | 3 |
| 7 | Heterologous protection against influenza by injection of DNA encod ing a viral protein显示文摘 | Ulmer J B Donnelly J J Parker S | 1993 | Science1993，259，5102： | 2 |
| 8 | Biochemical Effects of Mercury, Cadmium, and Lead显示文摘 | B L Vallee D D Ulmer | 1972 | Annual Review of Biochemistry1972，，： | 2 |
| 9 | FISH analysis in chromophobe renal cell carcinoma显示文摘 | IQBAL M A AKHTAR M ULMER C | 2000 | Diagn Cytopathol2000，22，1： | 1 |
| 10 | Functional MR of the primary auditory cortex: an analysis of pure tone activation and tone discrimination 显示文摘 | STRAINER J C ULMER J L YETKIN F Z | 1997 | AJNR1997，18，： | 1 |
| 11 | Vaccine manufacturing: challenges and solutions 显示文摘 | Ulmer J B Valley U Rappuoli R | 2006 | Nature Biotechnology2006，24，11： | 1 |
| 12 | DNA vaccines 显示文摘 | Donnelly JJ Ulmer JB Shiver JW | 1997 | Annu Rev Immunol1997，15，4： | 1 |
| 13 | Association,commissural,and projection pathways and their functional deficit reported in the literature显示文摘 | Aralasmak A Ulmer JL Kocak M | | 0，，05： | 1 |
| 14 | Heterologous protection a- gainst influenza by injection of DNA encoding a viral protein显示文摘 | Ulmer JB Donnelly JJ Parker SE | 1993 | Sci- ence1993，259，5102： | 1 |
| 15 | Endosonography of upper gastrointestinal tract cancer on demand using miniprobes or endoscopic ultrasound 显示文摘 | Hunerbein M Ulmer C Handke J | 2003 | Surg Endosc2003，17，4： | 1 |
| 16 | A role for Community Health Corp members in youth HIV/AIDS prevention education显示文摘 | MORRIS LA ULMER C CHIMNANI J | 2003 | J Seh Health2003，73，4： | 1 |
| 17 | Arginine vasopressin in advanced vasodilatory shock: a prospective,randomized,controlled study显示文摘 | Dunser MW Mayr AJ Ulmer H | 2003 | Circulation2003，107，： | 1 |
| 18 | Consistent questions of ambiguity in organizational crisis communication: Jack in the box as a case stndy显示文摘 | Ulmer R R Sel]now T L | 2000 | Jonrnal of Business Ethics2000，，25： | 1 |
| 19 | Superimposing ultrasonic waves on the dies in tube and wire drawing显示文摘 | SIEGERT K ULMER J | 2001 | Journal of Engineering Materials and Technology2001，123，4： | 1 |
| 20 | A CMOS voltage reference 显示文摘 | TSIVIDIS Y P ULMER R W | 1978 | IEEEJ Sol Sta Circ1978，13，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员