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| 1 | Dissolution improvement of fenofibrate by melting inclusion in mesoporous silica显示文摘In this study,using mesoporous silica for the solubility enhancement of poorly watersoluble drug was investigated.Although the incorporating drug into mesoporous silica is generally performed through the solvent method,the new melting method was proposed in the present study.Fenofibrate,a poorly water-soluble drug,was incorporated into mesoporous silica by solvent method and melting method.The obtained samples were observed by SEM and their physicochemical properties were evaluated by PXRD and DSC measurement.The dissolution and supersaturated property were also investigated.The results from SEM,PXRD and DSC measurement showed that drug could be loaded into pore via the melting method as well as by the solvent method.The drug loaded quantity depended on the pore volume.Drug up to 33%could be incorporated into mesoporous silica and existed in amorphous state.When drug was overloaded or difficulty in incorporation into pore was found,recrystallization of drug occurred at the outer surface of mesoporous silica.From the dissolution test,samples prepared by solvent method and melting method gave the supersaturated drug concentration which sample from melting method showed superior dissolution to the one from solvent method.From this study,drug was efficiently incorporated into mesoporous silica by the melting method which is a simple and solvent-free process,and the aqueous solubility enhancement of poorly watersoluble drug was achieved. | Fumiaki Uejo Waree Limwikrant Kunikazu Moribe Keiji Yamamoto | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，6： | 1 |
| 2 | Self-assembly of a silica-surfactant nanocomposite in a porous alumina membrane 显示文摘 | Yamaguchi A Uejo F Yoda T | 2004 | Nature Mater2004，，3： | 1 |
| 3 | Teramae, self-assembly of silica-surfactant nanocomposite in porous alumina membrane 显示文摘 | Yamaguchi A Uejo F Yoda T | 2004 | Nat Mater2004，3，： | 1 |
| 4 | Ultrasound Biomicroscopic Configurations of the Anterior Ocular Segment in a Population-Based Study显示文摘 | Ichiko Medoruma Henzan Atsuo Tomidokoro Chiharu Uejo Hiroshi Sakai Shoichi Sawaguchi Aiko Iwase Makoto Araie | 2010 | Ophthalmology2010，，9： | 1 |
| 5 | Self-assembly of a silica-surfactant nanocomposite in a porous alumina membrane显示文摘 | YAMAGUCHI A UEJO F YODA T | 2004 | Nature Materials2004，3，5： | 1 |
| 6 | Ultrasound Biomicroscopic Configurations of the Ante- rior Ocular Segment in a Population-Based Study显示文摘 | Henzan IM Tomidokoro A Uejo C Sakai H Sawaguchi S Iwase A | 2010 | Ophthal- mology2010，117，9： | 1 |
| 7 | Self-assembly of a silica-surfactant nanocomposite in a porous alumina membrane显示文摘 | Yamaguchi A Uejo F Yoda T | 2004 | Nature Mater2004，3，： | 1 |
| 8 | Ultrasound biomicroscopy configurations of the anterior ocular segment in a population-based study: the Kumejima study 显示文摘 | Henzan IM Tomidokoro A Uejo C | 2010 | Ophthalmology2010，117，9： | 1 |
| 9 | Self-assembly of a silica-surfactant nanocomposite in a porous alumina membrane 显示文摘 | YAMAGUCHI A UEJO F YODA T | 2004 | Nature Materials2004，3，5： | 1 |
| 10 | Self-assembly of a silica-surfactant nanocomposite in a porous alumina membrane显示文摘 | Yamaguchi A Uejo F Yoda T | 2004 | Natuer Mater2004，3，： | 1 |
| 11 | Structural control of surfactant-templated mesoporous silica formed inside columnar alumina pores显示文摘 | Yamaguchi A Uejo F Yoda T | 2004 | Nature Mater2004，5，： | 1 |
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