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| 1 | Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests显示文摘AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. METHODS: Blood flow(BF) was analyzed by arterial spin labeling(ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy(MHE). Images were collected using a 3 Tesla MR scanner(Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score(PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins(IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated.RESULTS: In patients with MHE, BF was increased in cerebellar hemisphere(P = 0.03) and vermis(P = 0.012) and reduced in occipital lobe(P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE(P = 0.02). Bimanual coordination was impaired in patients without MHE(P = 0.05) and much more in patients with MHE(P < 0.0001). Visuo-motor coordination was impaired only in patients with MHE(P < 0.0001). Attention was slightly affected in patients without MHE and more strongly in patients with MHE(P< 0.0001). BF in cerebellar hemisphere and vermis correlated with performance in most tests of PHES [(number connection tests A(NCT-A), B(NCT-B)and line tracing test] and in the congruent task of Stroop test. BF in frontal lobe correlated with NCT-A. Performance in bimanual and visuomotor coordination tests correlated only with BF in cerebellar hemisphere. BF in occipital lobe correlates with performance in the PHES battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide(NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe.CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum. | Vicente Felipo Amparo Urios Carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu | 2014 | World Journal of Gastroenterology2014，20，33： | 12 |
| 2 | Contribution of hyperam- monemia and inflammatory factors to cognitive impairment in mini- mal hepatic encephalopathy 显示文摘 | Felipo V Urios A Montesinos E | 2012 | Metab Brain Dis2012，27，1： | 1 |
| 3 | Urinary KIM-1,NGALand L-FABP for the diagnosis of AKI in patients with acute coronarysyndrome or heart failure undergoing coronary angiography 显示文摘 | Torregrosa I Montoliu Cf Urios A | 2015 | Heart Vessels2015，306，： | 1 |
| 4 | Urinary KIM-1,NGAL and L-FABP for the diagnosis of AKI in patients withacute coronary syndrome or heart failure undergoing coronaryangiography显示文摘 | Torregrosa I Montoliu C Urios A | 2015 | Heart Vessels2015，30，6： | 1 |
| 5 | Urinary KIM - 1, NGAL and L - FABP for the diagnosis of AKI in patients with a- cute coronary syndrome or heart failure undergoing coronary angiog- raphy显示文摘 | TORREGROSA I MONTOLIU C URIOS A | 2014 | Heart Vessels2014，，： | 1 |
| 6 | Screening formetabolites from Penicillium novae-zeelandiae displaying radical-scavenging activity and oxidative mutagenicity: Isolation of genti-syl alcohol显示文摘 | ALFARO C URIOS A GONZALEZ M C ei al | 2003 | Mutat Res2003，539，12： | 1 |
| 7 | 3-nitro-tyrosine as a peripheral biomarker of minimal hepatie eneephalopathy in patients with liver eirrhosis 显示文摘 | Montoliu C Cauli O Urios A | 2011 | Am J Gastroenterol2011，106，9： | 1 |
| 8 | Is cognitive impairment in cirrhotic patients due to increased peroxynitrite and oxidative stress?显示文摘 | Gimenez C C Urios A AgustíA | 2015 | Antioxid Redox Sig2015，22，10： | 1 |
| 9 | Urinary KIM-1,NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography显示文摘 | Torregrosa I Montoliu C Urios A | 2014 | Heart Vessels2014，3，： | 1 |
| 10 | 3-nitro-tyrosine as a peripheral biomarker of minimal hepatic encephalopathy in patients with livercirrhosis 显示文摘 | Montoliu C Cauli O Urios A | 2011 | Am J Gastroenterol2011，106，9： | 1 |
| 11 | Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coro- nary syndrome or heart failure undergoing coronary angiography 显示文摘 | Torregrosa I Montoliu C Urios A | 2015 | Heart Vessels2015，30，6： | 1 |
| 12 | A flavonoid fraction purified from Rutaceae aurantiae(Daflon R)inhibiting AGE formation,reduces urinary albumin clearance and corrects hypoalbuminemia in normotensive and hypertensive diabetic rats显示文摘 | Urios P Kassab I Grigorova-Borsos A M | 2014 | Diabetes Research and Clinical Practice2014，105，3： | 1 |
| 13 | Early biomarkers of a-cute kidney failure after heart angiography or heart surgery in patients with acute coronary syndrome or acute heart failure显示文摘 | Torregrosa I Montoliu C Urios A | | 0，，01： | 1 |
| 14 | Early biomarkers of acute kidney failure after heart angiography or heart surgery in patients with acute coronary syndrome or acute heart failure 显示文摘 | Torregrosa I Montoliu C Urios A | 2012 | Nefrologia2012，32，1： | 1 |
| 15 | Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure 显示文摘 | URIOS P GRIGOROVA-BORSOS A M STERNBERG M | 2007 | Eur J Nutr2007，46，： | 1 |
| 16 | Urinary KIM-1,NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography显示文摘 | Torregrosa I Montoliu C Urios A | 2014 | Heart Vessels2014，，： | 1 |
| 17 | Influence of reck mutationson gyrA dependent quinolone resistance 显示文摘 | Urios A Aleixandre V Blanco M | 1991 | Biochimie1991，73，4： | 1 |
| 18 | Continuous enrichment culture and molecular monitoring to investigate the microbial diversity of thermophiles inhabiting deep-sea hydrother-mal ecosystems 显示文摘 | POSTEC A URIOS L LESONGEUR F | 2005 | Current Microbiology2005，50，3： | 1 |
| 19 | Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy显示文摘 | FELIPO V URIOS A MONTESINOS E | 2012 | Metab Brain Dis2012，27，： | 1 |
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