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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | 世界家庭医生组织(WONCA)研究论文摘要汇编——以家庭为中心的抗抑郁疗法治疗老年男性抑郁患者遇到的挑战和解决方案:一项对利益相关者的研究显示文摘背景家庭成员在老年男性抑郁患者的生活中起到了非常重要的作用,其经常陪同患者去社区医院就诊。然而,对如何最有效地让患者家庭成员参与患者的治疗过程相关研究较少。由于一些原因,如抑郁的'病耻心'与家庭成员间的冲突,导致家庭成员很难参与患者的抗抑郁治疗。本研究旨在探究家庭成员参与老年男性抑郁患者的治疗所遇到的困难及其措施。方法本项横断面定性描述性访谈研究在位于加利福尼亚中央谷地的'安全网'联邦合格健康服务中心进行。37例研究对象中包含15例老年(≥60岁)男性抑郁患者(由邮件招募、候诊室招募和转诊患者组成)、12例患者家庭成员(在参与研究的患者家庭成员中招募),以及10例全科医务人员(通过目的抽样抽取)。对研究对象关于把家庭干预列为治疗老年男性抑郁的全科疗法之一的看法,进行了半结构式的访谈。访谈内容被录音、记录。结果访谈结果表明,家庭成员参与老年男性抑郁患者的治疗所遇到的主要困难有:让患者在适当的时机接受治疗;保持患者的自主性;处理患者个人隐私问题;处理家庭成员之间的冲突。对于如何解决这些困难,研究对象也提出了可行性的建议。结论尽管以家庭为中心的抗抑郁疗法是一项治疗老年男性抑郁患者有效的全科疗法,但是实施起来尚有一定困难。此疗法的继续开展以及临床应用需要研制出解决这些困难的方案和指南。 | HINTON L SCIOLLA A F UNüTZER J 本刊编辑部 | 2017 | 中国全科医学2017，20，32： | 4 |
| 3 | Postoperation symptoms 24 hours after ambulatory anesthesia显示文摘 | Un V Su J | 1996 | Can J Anaesth1996，43，11： | 1 |
| 4 | Crystal structure of mitochon- drial respiratory membrane protein complex Ⅱ 显示文摘 | UN F HUO X ZHAI Y | 2005 | Cell2005，121，： | 1 |
| 5 | Self - Diagnosing Intelligent Motors: a Key Enabler for Next Generation Manufacturing Systems 显示文摘 | Diseenzo F M Un~sworth P J Loparo K A | 2000 | Computing & Control Engineering Journal2000，，5： | 1 |
| 6 | Modulating ICBP90 to suppress human ribonucleotide reductase M2 induction restores sensitivity to hydroxyurea cytotoxicity显示文摘 | Un F Qi C Prosser M | 2006 | Anticancer Res2006，26，4： | 1 |
| 7 | Efficient route to organometallic cage formation via C-H activation-dirocted muff component assembly accompanying aromatic guest encapsulation显示文摘 | HAN Y F UN Y J ANDY HOR T S ct al | 2012 | Organometallics2012，3，3： | 1 |
| 8 | The effect of melatonin on protein oxidation and nitric oxide in the brain tissue of hypoxic neonatal rats显示文摘 | Eskiocak S Tutunculer F Basaran UN | 2007 | Brain Dev2007，29，1： | 1 |
| 9 | Identification and fine map-ping of Pi39 (t) , a major gene conferring the broad - spectrum re-sistance to Magnaporthe oryzae 显示文摘 | LIU X Q YANG QZ UN F | 2007 | Molecular Genetics and Ge-nomics2007，278，40： | 1 |
| 10 | Bcl-2 gene fam ily expressionin the brain of rat offspring after gestational andlactational dioxinexposure显示文摘 | Chang S F S un Y Y Y ang L Y f e ta l | | A nn N Y Acad S ci0，10，42： | 1 |
| 11 | Modulating ICBP90 to sup- press human ribonucleotide reductase M2 induction re- stores sensitivity to hydroxyurea cytotoxicity显示文摘 | Un F Qi C Prosser M | 2006 | Anticancer Res2006，26，4： | 1 |
| 12 | High optical switching speed and flexible electrochromic display based on WOa nano particles with ZnO nanorod arrays' supported electrode显示文摘 | Mingj un W Guojia F Longyan Y | 2009 | Nanotechnology2009，20，18： | 1 |
| 13 | Analysis and design of open-loop multiphase local-oscillation generator for wireless applications显示文摘 | UN K F MAK P I | 2010 | IEEE Transactions On Circuits and Systems2010，57，5： | 1 |
| 14 | The protective role of melatonin in experimental hypoxic brain damage显示文摘 | Tutunculer F Eskiocak S Basaran UN | 2005 | Pediatr Int2005，47，4： | 1 |
| 15 | Adaptive gaussianfiltering and local frequency estimates using local curvatureanalysis 显示文摘 | HODSON E K THAYER D R’UN C F | 1981 | IEEE Transactions on Singal Proceeding1981，29，4： | 1 |
| 16 | Omega- 3 fatty acid concentrates : nutritional aspects and production technologies 显示文摘 | Shahidi F Wanasundara UN | 1998 | Trends in Food Science & Technology1998，，9： | 1 |
| 17 | Postoperation symptoms 24 hours after ambulatory anesthesia显示文摘 | Chung F Un V Su J | 1996 | Can J Anaesth1996，43，： | 1 |
| 18 | Tuberculosis: do we know enough? A study of patients and their families in an outpatient hospital setting in Karachi, Pakistan显示文摘 | Ali SS Rabbani F Siddiqui UN | 2003 | Int J Tuberc Lung Dis2003，7，11： | 1 |
| 19 | Isolation and analysis of purine alkaloids from Camellia ptilophylla Chang显示文摘 | Ye C Un Y Zhou H Cheng F Li X | | 0，，： | 1 |
| 20 | Isolation and characteriza-tion of new lactam compounds that inhibit lung and colon cancercells from adlay bran显示文摘 | LEE M Y UN H Y CHENG F | 2008 | Food and Chemical Toxicology2008，，46： | 1 |
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