|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | PTEN inhibition and axon regeneration and neural repair显示文摘The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling proteins and transcription factors have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for controlling axon elongation. As a negative regulator of this pathway, the tumor suppressor phosphatase and tensin homolog(PTEN) appears critical to control the regenerative ability of young and adult neurons. This review will focus on recent research progress in axon regeneration and neural repair by PTEN inhibition and therapeutic potential of blocking this phosphatase for neurological disorders. Inhibition of PTEN by deletion in conditional knockout mice, knockdown by short-hairpin RNA, or blockade by pharmacological approaches, including administration of selective PTEN antagonist peptides, stimulates various degrees of axon regrowth in juvenile or adult rodents with central nervous system injuries. Importantly, post-injury PTEN suppression could enhance axonal growth and functional recovery in adult central nervous system after injury. | Yosuke Ohtake Umar Hayat Shuxin Li | 2015 | Neural Regeneration Research2015，10，9： | 14 |
| 2 | Zinc Oxide Nanostructures for NO_2 Gas–Sensor Applications:A Review显示文摘Because of the interesting and multifunctional properties,recently,ZnO nanostructures are considered as excellent material for fabrication of highly sensitive and selective gas sensors.Thus,ZnO nanomaterials are widely used to fabricate efficient gas sensors for the detection of various hazardous and toxic gases.The presented review article is focusing on the recent developments of NO2gas sensors based on ZnO nanomaterials.The review presents the general introduction of some metal oxide nanomaterials for gas sensing application and finally focusing on the structure of ZnO and its gas sensing mechanisms.Basic gas sensing characteristics such as gas response,response time,recovery time,selectivity,detection limit,stability and recyclability,etc are also discussed in this article.Further,the utilization of various ZnO nanomaterials such as nanorods,nanowires,nano-micro flowers,quantum dots,thin films and nanosheets,etc for the fabrication of NO2gas sensors are also presented.Moreover,various factors such as NO2concentrations,annealing temperature,ZnO morphologies and particle sizes,relative humidity,operating temperatures which are affecting the NO2gas sensing properties are discussed in this review.Finally,the review article is concluded and future directions are presented. | Rajesh Kumar O.Al-Dossary Girish Kumar Ahmad Umar | 2015 | Nano-Micro Letters2015，7，2： | 13 |
| 3 | Micro RNAs in colorectal cancer:Role in metastasis and clinical perspectives显示文摘Colorectal cancer(CRC)is the third most common malignancy and the third leading cause of cancer related deaths in the United States.Almost 90%of the patients diagnosed with CRC die due to metastases.Micro RNAs(mi RNAs)are evolutionarily conserved molecules that modulate the expression of their target genes post-transcriptionally,and they may participate in various physiological and pathological processes including CRC metastasis by influencing various factors in the human body.Recently,the role mi RNAs play throughout the CRC metastatic cascade has gain attention.Many studies have been published to link them with CRC metastasis.In this review,we will briefly discuss metastatic steps in the light of mi RNAs,along with their target genes.We will discuss how the aberration in the expression of mi RNAs leads to the formation of CRC by effecting the regulation of their target genes.As mi RNAs are being exploited for diagnosis,prognosis,and monitoring of cancer and other diseases,their high tissue specificity and critical role in oncogenesis make them new biomarkers for the diagnosis and classification of cancer as well as for predicting patients’outcome.Mi RNA signatures have been identified for many human tumors including CRC,and mi RNA-based therapies to treat cancer have been emphasized lately.These will also be discussed in this review. | Shan Muhammad Kavanjit Kaur Rui Huang Qian Zhang Paviter Kaur Hamza Obaid Yazdani Muhammad Umar Bilal Jiang Zheng Liu Zheng Xi-Shan Wang | 2014 | World Journal of Gastroenterology2014，20，45： | 13 |
| 4 | Low-Dimensional Halide Perovskites and Their Advanced Optoelectronic Applications显示文摘Metal halide perovskites are crystalline materials originally developed out of scientific curiosity. They have shown great potential as active materials in optoelectronic applications. In the last 6 years, their certified photovoltaic efficiencies have reached 22.1%. Compared to bulk halide perovskites, low-dimensional ones exhibited novel physical properties. The photoluminescence quantum yields of perovskite quantum dots are close to 100%. The external quantum efficiencies and current efficiencies of perovskite quantum dot light-emitting diodes have reached 8% and 43 cd A^(-1),respectively, and their nanowire lasers show ultralow-threshold room-temperature lasing with emission tunability and ease of synthesis. Perovskite nanowire photodetectors reached a responsivity of 10 A W^(-1)and a specific normalized detectivity of the order of 10^(12 )Jones. Different from most reported reviews focusing on photovoltaic applications, we summarize the rapid progress in the study of low-dimensional perovskite materials, as well as their promising applications in optoelectronic devices. In particular, we review the wide tunability of fabrication methods and the state-of-the-art research outputs of low-dimensional perovskite optoelectronic devices. Finally, the anticipated challenges and potential for this exciting research are proposed. | Jian Zhang Xiaokun Yang Hui Deng Keke Qiao Umar Farooq Muhammad Ishaq Fei Yi Huan Liu Jiang Tang Haisheng Song | 2017 | Nano-Micro Letters2017，9，3： | 10 |
| 5 | 酶法生产橄榄混浊汁显示文摘确定了酶法生产橄榄混浊汁的最佳工艺条件 ,研究了果胶酶对橄榄果汁的产量和提取率的影响。当果胶酶的含量大于0 0 1%时 ,果汁的提取率提高但产量下降 ,果汁颜色不理想 ;温度 3 0℃时 ,产率最高 ;酶解时间 1h ,产率和提取效率都最好。由于橄榄中含有大量的果胶 ,果胶酶的加入 ,使果汁的产率提高了 2 0 %~ 3 0 % ,提取率提高了 5 %~ 7% 。 | Umar Ssonko Lule 夏文水 | 2004 | 饮料工业2004，17，6： | 10 |
| 6 | Biological process of soil improvement in civil engineering:A review显示文摘The concept of using biological process in soil improvement which is known as bio-mediated soil improvement technique has shown greater potential in geotechnical engineering applications in terms of performance and environmental sustainability.This paper presents a review on the soil microorganisms responsible for this process,and factors that affect their metabolic activities and geometric compatibility with the soil particle sizes.Two mechanisms of biomineralization,i.e.biologically controlled and biologically induced mineralization,were also discussed.Environmental and other factors that may be encountered in situ during microbially induced calcite precipitation(MICP) and their influences on the process were identified and presented.Improvements in the engineering properties of soil such as strength/stiffness and permeability as evaluated in some studies were explored.Potential applications of the process in geotechnical engineering and the challenges of field application of the process were identified. | Murtala Umar Khairul Anuar Kassim Kenny Tiong Ping Chiet | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，5： | 9 |
| 7 | Recent Advances in Interface Engineering for Electrocatalytic CO_(2) Reduction Reaction显示文摘Electrocatalytic CO_(2) reduction reaction(CO_(2) RR) can store and transform the intermittent renewable energy in the form of chemical energy for industrial production of chemicals and fuels,which can dramatically reduce CO_(2) emission and contribute to carbon-neutral cycle. E cient electrocatalytic reduction of chemically inert CO_(2) is challenging from thermodynamic and kinetic points of view. Therefore,low-cost,highly e cient,and readily available electrocatalysts have been the focus for promoting the conversion of CO_(2). Very recently,interface engineering has been considered as a highly e ective strategy to modulate the electrocatalytic performance through electronic and/or structural modulation,regulations of electron/proton/mass/intermediates,and the control of local reactant concentration,thereby achieving desirable reaction pathway,inhibiting competing hydrogen generation,breaking binding-energy scaling relations of intermediates,and promoting CO_(2) mass transfer. In this review,we aim to provide a comprehensive overview of current developments in interface engineering for CO_(2) RR from both a theoretical and experimental stand-point,involving interfaces between metal and metal,metal and metal oxide,metal and nonmetal,metal oxide and metal oxide,organic molecules and inorganic materials,electrode and electrolyte,molecular catalysts and electrode,etc. Finally,the opportunities and challenges of interface engineering for CO_(2) RR are proposed. | Junjun Li Sulaiman Umar Abbas Haiqing Wang Zhicheng Zhang Wenping Hu | 2021 | Nano-Micro Letters2021，13，12： | 9 |
| 8 | Impact of organic interlayer anions on the CO2 adsorption performance of Mg-Al layered double hydroxides derived mixed oxides显示文摘Herein we report a systematical investigation on the promoting effect of the carbon chain length of the intercalated carboxylic anions on the CO_2 capture performance of Mg-Al layer double hydroxides(LDHs).A series of organo-LDHs were successfully synthesized via co-precipitation and calcination-rehydration methods. All as-prepared samples were characterized by many techniques including XRD, ATR-FTIR, BET,and TGA. The XRD and ATR-FTIR studies indicated that organic anions were successfully intercalated into LDHs. The influence of some important parameters such as calcination temperature, adsorption temperature, and coating with(Li-Na-K)NO_3 molten salt was investigated. The results exhibited that when the number of carbon is greater than 10, the CO_2 capture capacity steadily increased with the increase in carbon number. After coating with 55 mol%(Li-Na-K)NO_3 molten salt, the CO_2 uptake of LDH-C16 sample with high Mg/Al ratios can be increased up to 3.25 mmol/g. The CO_2 adsorption/desorption cycling stability was also studied using temperature swing adsorption, which showed a stable CO_2 capture performance even after 22 cycles. Considering its high CO_2 capture capacity and good cycling stability, this novel CO_2 adsorbent is very promising in the sorption-enhanced water gas shift(SEWGS) processes. | Qingqing Qin Junya Wang Tuantuan Zhou Qianwen Zheng Liang Huang Yu Zhang Peng Lu Ahmad Umar Benoit Louis Qiang Wang | 2017 | Journal of Energy Chemistry2017，26，3： | 8 |
| 9 | Iatrogenic bile duct injuries from biliary tract surgery显示文摘BACKGROUND:Cholecystectomy is the most commonly performed procedure in general surgery.However,bile duct injury is a rare but still one of the most common complications.These injuries sometimes present variably after primary surgery.Timely detection and appropriate management decrease the morbidity and mortality of the operation. METHODS:Five cases of iatrogenic bile duct injury(IBDI) were managed at the Department of Surgery,First Affiliated Hospital,Xi'an Jiaotong University.All the cases who underwent both open and laparoscopic cholecystectomy had persistent injury to the biliary tract and were treated accordingly. RESULTS:Recovery of the patients was uneventful.All patients were followed-up at the surgical outpatient department for six months to three years.So far the patients have shown good recovery. CONCLUSIONS:In cases of IBDI it is necessary to perform the operation under the supervision of an experienced surgeon who is specialized in the repair of bile duct injuries,and it is also necessary to detect and treat the injury as soon as possible to obtain a satisfactory outcome. | Umar Ali | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 8 |
| 10 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 11 | 鸡源产气荚膜梭菌重组酶聚合酶扩增检测方法的建立显示文摘为建立鸡源产气荚膜梭菌(Clostridium perfringens)的快速诊断方法,本研究以产气荚膜梭菌α-毒素的编码基因plc为基础设计、合成引物和探针,并以real-time PCR的方法进行验证,建立了鸡源产气荚膜梭菌的重组酶聚合酶扩增(RPA)检测方法。该方法可在38℃、25 min内对产气荚膜梭菌的α-毒素编码序列进行快速特异性扩增,最低检测限量可达1×10^1copies/μL,灵敏度良好。以此方法检测实验室保存的临床样本,其检测结果与real-time PCR的检测结果一致。上述结果表明,本研究建立的real-time RPA方法在检测鸡源产气荚膜梭菌时具有操作简单、快速灵敏的特点,适用于鸡源产气荚膜梭菌的临床检测。 | 许笑 王艳华 M Umar Zafar Khan 王恒 蔡建平 | 2019 | 中国兽医科学2019，49，12： | 6 |
| 12 | Thermo-diffusion effects on MHD stagnation point flow towards a stretching sheet in a nanofuid显示文摘Thermodiffusion effects on stagnation point flow of a nanofuid towards a stretching surface with applied magnetic field is presented.Similarity transforms are applied to reduce the equations that govem the flow to a system of nonlinear ordinary differential equations.Runge-K utta-Fehlberg method is applied to solve the sy stem.Results are compared with existing solutions that are special cases to our problem.Concrete graphical analysis is carried out to study the effects of different emerging parameters such as stretching ratio A,mag netic infuence parameter M,Prandtl number Pr,Lewis number Le,Brownian motion parameter Nb,thermophoresis parameter Nr,nanofluid Lewis number Ln,modified Dufour parameter Nd and Dufour solutal number Ld coupled with comprehensive discussions.Numerical effects of local Nusselt number,local Sherwood number and nanofluid Sherwood number are also discussed. | Umar Khan Naveed Ahmed Sheikh Irfan Ullah Khan Syed Taluseef Mohyud-din | 2014 | Propulsion and Power Research2014，3，3： | 5 |
| 13 | Molecular study of HCV detection,genotypes and their routes of transmission in North West Frontier Province,Pakistan显示文摘Objective:To determine hepatitis C virus(HCV) genotypes and explore the associated risk factors in chronic HCY patients.Methods:A total of 116 patients with chronic hepatitis C were subjected to polymerase chain reaction(PCR) based detection out of which 112 chronic HCV patients[53 male(47.32%),59 female(52.68%);mean age(43.76±16.40) years;mean BMI(23.8± 3.9)kg]were enrolled in this study.The frequency of 6 HCV genotypes and associated risk factors were evaluated from five districts of North West Frontier Province(NWFP).Results:Genotype 3was the most prevalent in 73 samples(65.17%) followed by genotype 1 in 24(21.42%) and genotype2 in 13(11.60%) samples.Genotype3 had significantly high prevalence(P=0.0002).The results showed that 48(42.85%) samples were infected with HCV 3a:25(22.32%) with 3b;14(12.50%) with 1a;10(8.92%)with 1b;11(9.82%) with 2a;2(1.78%) with 2b;and 2 were untypable.The distribution of HCV genotypes in Murdan.Charsadda,Peshawar.Sawabi and Nowshehra districts was different.Use of unsterile equipment lor medication,barbers and previous history of hospitalization were the main risk factors for HCV transmission.Conclusions:Cenotype 3a and 3b.1a.1b and 2a are the common genotypes in NWFP.Genotype 4.5.and 6 can not be found in a single sample.The level of awareness about various modes ot transmission of HCV among the population is found to be verv low. | Asher Zaman Safi Yasir Waheed Joharia Sadat Solat-Ul-Islam Sadia Salahuddin Umar Saeed Muhammad Ashraf | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，7： | 5 |
| 14 | Fungi as chemical industries and genetic engineering for the production of biologically active secondary metabolites显示文摘Fungi is somewhere in between the micro and macro organisms which is a good source of producing biologically active secondary metabolites.Fungi have been used as tool for producing different types of secondary metabolites by providing different nutrients at different laboratory conditions.The fungi have been engineered for the desired secondary metabolites by using different laboratory techniques,for example,homologous and heterologous expressions.This review reported how the fungi are used as chemical industry for the production of secondary metabolites and how they are engineered in laboratory for the production of desirable metabolites:also the biosynthetic pathways of the bio-organic-molecules were reported. | Abid Ali Khan Nafees Bacha Bashir Ahmad Ghosia Lutfullah Umar Farooq Russell John Cox | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，11： | 5 |
| 15 | Continuous wound infusion of local anaesthetic agents following colorectal surgery:Systematic review and meta-analysis显示文摘AIM:To provide a specifi c review and meta-analysis of the available evidence for continuous wound infusion of local anaesthetic agents following midline laparoto-my for major colorectal surgery. METHODS: Medline, Embase, trial registries, conference proceedings and article reference lists were searched to identify randomised, controlled trials of continuous wound infusion of local anaesthetic agents following colorectal surgery. The primary outcomes were opioid consumption, pain visual analogue scores (VASs), return to bowel function and length of hospital stay. Weighted mean difference were calculated for continuous outcomes. RESULTS: Five trials containing 542 laparotomy wounds were eligible for inclusion. There was a sig- nificant decrease in post-operative pain VAS at rest on day 3 (weighted mean difference: -0.43; 95% CI: -0.81 to -0.04; P = 0.03) but not on post-operative day 1 and 2. Local anaesthetic infusion was associated with a signifi cant reduction in pain VAS on movement on all three post-operative days (day 1 weighted mean difference: -1.14; 95% CI: -2.24 to -0.041; P = 0.04, day 2 weighted mean difference: -0.97, 95% CI: -1.91to -0.029; P = 0.04, day 3 weighted mean difference: -0.61; 95% CI: 1.01 to -0.20; P = 0.0038). Local an- aesthetic wound infusion was associated with a signifi - cant decrease in total opioid consumption (weighted mean difference: -40.13; 95% CI: -76.74 to -3.53; P = 0.03). There was no signifi cant decrease in length of stay (weighted mean difference: -20.87; 95% CI: -46.96 to 5.21; P = 0.12) or return of bowel function (weighted mean difference: -9.40; 95% CI: -33.98 to 15.17; P = 0.45). CONCLUSION: The results of this systematic re- view and meta-analysis suggest that local anaesthetic wound infusion following laparotomy for major color- ectal surgery is a promising technique but do not pro- vide conclusive evidence of benefi t. Further research is required including cost-effectiveness analysis. | Alan Karthikesalingam Stewart R Walsh Sheraz R Markar Umar Sadat Tjun Y Tang Charles M Malata | 2008 | World Journal of Gastroenterology2008，14，34： | 4 |
| 16 | 恙虫病东方体目视LAMP现场化检测方法的建立显示文摘目的建立基于“染料-蜡丸”的目视LAMP检测恙螨中恙虫病东方体的方法,为恙虫病的防治提供新工具。方法选择Ot GroEL基因作为检测靶序列,在线设计并合成LAMP引物。构建r Ot-GroEL重组质粒作为阳性对照。建立基于SYBR Green I的“染料-蜡丸”目视LAMP,并联合便携式LAMP仪使其利于现场应用。结果新设计的引物针对Ot GroEL基因的237 bp靶区域,所构建的重组质粒r Ot-GroEL测序结果正确。在便携式LAMP仪上运用“染料-蜡丸”目视LAMP法,其检测下限为1×10^2拷贝质粒。结论成功建立了一种可与便携式LAMP仪联合使用的检测恙螨体内恙虫病东方体的“染料-蜡丸”目视LAMP法。 | 陶志勇 UMAR Ibrahim 吕樵岚 刘韦萍 张培艺 靳小霞 方强 夏惠 | 2021 | 热带病与寄生虫学2021，19，1： | 4 |
| 17 | Prevalence and risk factors associated with malaria infection among pregnant women in a semi-urban community of north-western Nigeria显示文摘Background:Malaria during pregnancy remains a serious public health problem,with substantial risks for the mother,her foetus and the newborn.The aim of this study was to determine the prevalence of malaria and possible risk factors for malaria infection among pregnant women in a semi-urban area in north-western Nigeria.Pregnant women are among the most susceptible to malaria infection.Knowledge of their malaria infection status is an important yardstick to measure the effectiveness of any malaria control programme.Methods:We conducted a cross sectional study in the semi-urban area of Argungu,Kebbi State Nigeria.Two hundred and fifty five pregnant women were included in the study after informed verbal consent was obtained.For each participant,the socio-demographic profile,stage of pregnancy and attitude to the use of insecticide-treated nets(ITNs)were investigated using a questionnaire.Peripheral blood samples were collected and thick blood smears were prepared and stained with Giemsa stains to check for malaria parasitaemia.The associations between age,education level and use of ITNs with occurrence of malaria infection during pregnancy were analysed using the chi-square test.Results:One hundred and six(41.6%)out of 255 pregnant women were infected with malaria parasites,with a mean parasite density of 800 parasitesμl−1.It was found that prevalence and parasite density decreased as age increased.The chi-square test indicated that a lack of education and non-usage of ITNs were significantly associated with malaria infection.Conclusion:Malaria is still a major public health issue among pregnant women mainly due to illiteracy and non-compliance to using ITNs.Increasing awareness about malaria preventive measures and early attendance of antenatal care services will help to reduce malaria and,consequently,its associated morbidities and mortalities. | Sani Abdullahi Fana Mohammed Danladi Abubakar Bunza Sule Aliyu Anka Asiya Umar Imam Shehu Usman Nataala | 2015 | Infectious Diseases of Poverty2015，4，1： | 4 |
| 18 | Dynamic spillovers between the term structure of interest rates,bitcoin,and safe‑haven currencies显示文摘This study examines the connectedness between the US yield curve components(i.e.,level,slope,and curvature),exchange rates,and the historical volatility of the exchange rates of the main safe-haven fiat currencies(Canada,Switzerland,EURO,Japan,and the UK)and the leading cryptocurrency,the Bitcoin.Results of the static analysis show that the level and slope of the yield curve are net transmitters of shocks to both the exchange rate and its volatility.The exchange rate of the Euro and the volatility of the Euro and the Canadian dollar exchange rate are net transmitters of shocks.Meanwhile,the curvature of the yield curve and the Japanese Yen,Swiss Franc,and British Pound act mainly as net receivers.Our static connectedness analysis shows that Bitcoin is mainly independent of shocks from the yield curve’s level,slope,and curvature,and from any main currency investigated.These findings hint that Bitcoin might provide hedging benefits.However,similar to the static analysis,our dynamic analysis shows that during different periods and particularly in stressful times,Bitcoin is far from being isolated from other currencies or the yield curve components.The dynamic analysis allows us to observe Bitcoin’s connectedness in times of stress.Evidence supporting this contention is the substantially increased connectedness due to policy shocks,political uncertainty,and systemic crisis,implying no empirical support for Bitcoin’s safe-haven property during stress times.The increased connectedness in the dynamic analysis compared with the static approach implies that in normal times and especially in stressful times,Bitcoin has the property of a diversifier.The results may have important implications for investors and policymakers regarding their risk monitoring and their assets allocation and investment strategies. | David Y.Aharon Zaghum Umar Xuan Vinh Vo | 2021 | Financial Innovation2021，7，1： | 4 |
| 19 | Effects of viscous dissipation and slip velocity on two-dimensional and axisymmetric squeezing flow of Cu-water and Cu-kerosene nanofluids显示文摘Squeezing flow of nanofluids has been taken into account under the effects of viscous dissipation and velocity slip.Two types of base fluids are used to study the behavior of Copper nanoparticles between parallel plates.Nonlinear ordinary differential equations governing the flow are obtained by imposing similarity transformations on conservation laws.Resulting equations are solved by using an efficient analytical technique the variation of parameters method(VPM).Influences of nanoparticle concentration and different emerging parameters on flow profiles are presented graphically coupled with comprehensive discussions.A numerical solution is also sought for the sake of comparison.Effect of different parameters on skin friction coefficient and Nusselt number is also discussed. | Umar Khan Naveed Ahmed Mir Asadullah Syed Tauseef Mohyud-din | 2015 | Propulsion and Power Research2015，4，1： | 4 |
| 20 | Macrophages are the primary effector cells in IL-7-induced arthritis显示文摘Synovial macrophages are crucial in the development of joint inflammation and bone damage;however, the pathways that controlmacrophage remodeling in inflammatory M1 cells or bone-eroding osteoclasts are not fully understood. We determined thatelevated IL-7R/CD127 expression is the hallmark of rheumatoid arthritis (RA) M1 macrophages and that these cells are highlyresponsive to interleukin-7 (IL-7)-driven osteoclastogenesis. We established that lipopolysaccharide (LPS), interferon-γ (IFNγ), andtumor necrosis factor-α (TNFα), the classic M1 macrophage mediators, enhance IL-7R expression in RA and murine macrophages.The local expression of IL-7 provokes arthritis, predominantly through escalating the number of F480^(+)iNOS^(+) cells rather than CD3^(+)T cells. Ectopic LPS injection stabilizes IL-7-induced arthritis by increasing myeloid IL-7R expression, in part via IFNγ induction.Hence, in RAG−/− mice, IL-7-mediated arthritis is suppressed because of the reduction in myeloid IL-7R expression due to the lackof IFNγ. Moreover, the amelioration of IL-7-induced arthritis by anti-TNF therapy is due to a decrease in the number of cells in theunique F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) subset, with no impact on the F480^(+)Arginase^(+) cell or CD3^(+) T cell frequency. Consistent with thepreclinical findings, the findings of a phase 4 study performed with RA patients following 6 months of anti-TNF therapy revealedthat IL-7R expression was reduced without affecting the levels of IL-7. This study shifts the paradigm by discovering that IL-7-induced arthritis is dependent on F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) cell function, which activates TH-1 cells to amplify myeloid IL-7Rexpression and disease severity. | Seung-jae Kim Huan J.Chang Michael VVolin Sadiq Umar Katrien Van Raemdonck Aimee Chevalier Karol Palasiewicz John W.Christman Suncica Volkov Shiva Arami Mehrdad Maz Anjali Mehta Ryan K.Zomorrodi David A.Fox Nadera Sweiss Shiva Shahrara | 2020 | Cellular & Molecular Immunology2020，17，7： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员