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| 1 | Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases显示文摘Anti-tumor necrosis factor(TNF) antibodies are successfully used in the therapy of inflammatory bowel diseases(IBD). However, the molecular mechanism of action of these agents is still a matter of debate. Apart from neutralization of TNF, influence on the intestinal barrier function, induction of apoptosis in mucosal immune cells, formation of regulatory macrophages as well as other immune modulating properties have been discussed as central features. Nevertheless, clinically effective anti-TNF antibodies were shown to differ in their mode-of-action in vivo and in vitro. Furthermore, the anti-TNF agent etanercept is effective in the treatment of rheumatoid arthritis but failed to induce clinical response in Crohn's disease patients, suggesting different contributions of TNF in the pathogenesis of these inflammatory diseases. In the following, we will review different aspects regarding the mechanism of action of anti-TNF agents in general and analyze comparatively different effects of each antiTNF agent such as TNF neutralization, modulation of the immune system, reverse signaling and induction of apoptosis. We discuss the relevance of the membranebound form of TNF compared to the soluble form for the immunopathogenesis of IBD. Furthermore, we review reports that could lead to personalized medicine approaches regarding treatment with antiTNF antibodies in chronic intestinal inflammation, by predicting response to therapy. | Ulrike Billmeier Walburga Dieterich Markus F Neurath Raja Atreya | 2016 | World Journal of Gastroenterology2016，22，42： | 19 |
| 2 | 中国第四纪晚期孢粉记录整理显示文摘孢粉数据库是重建过去植被格局以及研究古气候变化和大气圈-生物圈-人类活动相互关系的基础,而孢粉取样信息的记录和整理是建立孢粉数据库的重要前提。该文在收集我国1960–2008年发表的孢粉研究文献的基础上,整理分析了第四纪晚期,尤其是2万年以来(全新世为主)全国孢粉采样点的信息,包括采样地点名称、详细采样位置、省份、采样点经纬度和海拔高度、样品类型、取样深度、孢粉样品数量、14C测年数量及年代记录、覆盖的时间段和参考文献。总结发现,我国目前共有2324个表土/湖泊表层花粉采样点和987个第四纪晚期的地层沉积剖面和钻孔,其中高质量的地层孢粉采样点714个。虽然我国以及部分国际上从事第四纪研究的科学家尽了最大努力开展中国疆域的孢粉学研究,但由于人力、物力以及地形条件的限制,在我国仍然存在部分孢粉采样的'地理空隙',比如北方和西北荒漠地区、青藏高原无人区、中南部山区和东部人类活动频繁区域。然而,该数据信息库的不断完善,将为中国第四纪孢粉数据库的建立奠定良好基础。 | 倪健 陈瑜 Ulrike HERZSCHUH 董丹 | 2010 | 植物生态学报2010，34，8： | 17 |
| 3 | 鼻腔鼻窦嗅神经母细胞瘤的手术径路探讨显示文摘目的 总结鼻腔鼻窦嗅神经母细胞瘤 (esthesioneuroblastoma,ENB)的临床经验。方法 对Fulda医院耳鼻咽喉 头颈及面部整形外科 1 988年 7月~ 2 0 0 1年 1 2月经治的 1 7例ENB的临床资料、手术治疗的径路、方法及预后进行回顾性分析。结果 据Morita等的临床分期标准 ,1 7例中A期1例 ,B期 6例 ,C期 9例 ,D期 1例。术后 8~ 1 63个月 (平均 44个月 )的随访观察结果表明 :2年既无复发、亦无转移的总生存率 90 90 % (1 0 / 1 1 ) ,其中A期为 1 / 1、B期为 6/ 6、C期为 3/ 3、D期为 0 / 1。所有经鼻内径路手术的 6例患者至今均存活 ,临床和影像学检查都无复发和转移迹象 ,存活最长者已达1 30个月 ;2例经额下径路手术的C期患者在随访的 8、2 7个月内均未发现复发和转移 ;经面正中掀翻径路手术的B、C期患者各 1例已分别存活 1 63个月和 82个月 ,均无复发和转移。 6例在此观察期间死于ENB :其中C期 5例、D期 1例 ;Ⅱ级 1例、Ⅲ级 1例、Ⅳ级 3例 (另 1例未行分级诊断 )。 1例 (C期/Ⅱ级 )于ENB术后 7年死于星形细胞瘤 ,此间一直无ENB复发。结论 联合应用手术和放射治疗ENB的效果最佳。前颅底恶性肿瘤的手术治疗径路选择应按照以下原则 :若病变组织没有浸润至颅内或眶内 ,采用鼻内径路 ; | 游学俊 Wolfgang Draf Ulrike Bockmühl | 2003 | 中华耳鼻咽喉科杂志2003，38，3： | 12 |
| 4 | 产业技术研究院的创新管理显示文摘本刊上期刊登了冷民等人的《公共产业技术研究院促进区域创新发展》一文,总结了此类研发机构的创新特点,以及在市场经济体系下高层次产业技术研究院对区域经济社会发展的重要促进作用。本文进一步以德国弗劳恩霍夫应用研究促进协会、日本独立行政法人产业技术综合研究所、台湾财团法人工业技术研究院三家具有相当代表性的产业技术研发机构为例,讨论分析公共产业技术研究院创新管理的三条重要经验。 | 冷民 Ulrike Tagscherer 刘海波 韩小丁 | 2011 | 科技潮2011，，5： | 11 |
| 5 | Breath and string test: A diagnostic package for the identification of treatment failure and antibiotic resistance of Helicobacter pylori without the necessity of upper gastrointestinal endoscopy显示文摘AIM: Helicobacter pylori ( H pylofi) resistance after failed eradication has a major impact on the outcome of a further treatment regimen. The aim of this study was to assess the validity of a non-invasive strategy using the 13C-urea breath test (UBT) and the gastric string test in identifying post-treatment resistance of Hpylori.METHODS: The UBT was routinely performed 4 to 6 wk after H pylorieradication therapy. Forty-two patients (24 females, 18 males, mean age 48 years) with a positive UBT were included in the study. A gastric string test using a capsule containing a 90 cm-long nylon fiber was performed.Before the capsule was swallowed, the free end of the string was taped to the cheek. After one hour in the stomach, the string was withdrawn. The distal 20 cm of the string was inoculated onto an agar plate and processed under microaerophilic conditions. Following the string test, upper gastrointestinal endoscopy was performed to obtain gastric biopsies for conventional culture.RESULTS: H pyloriwas successfully cultured from the gastric string in 34 patients (81%), but not in 5 patients due to contamination with oropharyngeal flora. Hpyloriwas cultured from the gastric biopsies obtained at endoscopy in 39 patients (93%).CONCLUSION: The UBT followed by the gastric string test in the case of treatment failure is a valid diagnostic strategy with the aim of determining the post-therapeutic antibiotic resistance of Hpyloriwith little inconvenience to the patient.Upper GI-endoscopy can be avoided in several cases by applying consequently this diagnostic package. | Andreas Leodolter Kathlen Wolle Ulrike von Arnim Stefan Kahl Gerhard Treiber Matthias P.Ebert Ulrich Peitz Peter Malfertheiner | 2005 | World Journal of Gastroenterology2005，11，4： | 10 |
| 6 | Incidence trends and survival prediction of hepatoblastoma in children:a population-based study显示文摘Background:Hepatoblastoma is a rare disease that nevertheless accounts for the majority of liver malignancies in children.Due to limited epidemiological data,therapy for hepatoblastoma tends to be individualized.This study aimed to evaluate incidence trends of hepatoblastoma and to develop a nomogram to predict the survival of children with newly diagnosed hepatoblastoma on a population-based level.Methods:Individuals up to 18 years of age with hepatoblastoma recorded in 18 registries of the Surveillance,Epi-demiology,and End Results(SEER)database between 2004 and 2015 were examined.Joinpoint regression analyses were applied to assess incidence trends in annual percentage change(APC).Multivariable Cox regression was used to identify factors associated with overall survival(OS).A nomogram was constructed to predict OS in individual cases based on independent predictors.Concordance index(C-index)and calibration curves were used to evaluate predic-tive performance.Results:Between 2004 and 2015,hepatoblastoma incidence increased significantly(APC,2.2%;95%confidence interval[CI]0.5%to 3.8%,P<0.05).In particular,this increase was observed among 2-to 4-year-old patients,males,and African-Americans.The 5-and 10-year OS rates were 81.5%and 81.0%,respectively.Age of 2 to 4 years,Afri-can-American ethnicity,and no surgery were independent predictors for short OS.Distant disease at presentation was found not to be an independent factor of survival.The nomogram had a C-index of 0.79(95%CI 0.74-0.84)with appropriate calibration curve fitting.Conclusions:We constructed a nomogram that integrates common factors associated with survival for hepatoblas-toma patients.It provides accurate prognostic prediction for children with hepatoblastoma. | Jincheng Feng Georgios Polychronidis Ulrike Heger Giovanni Frongia Arianeb Mehrabi Katrin Hoffmann | 2019 | Cancer Communications2019，39，1： | 10 |
| 7 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 8 | Long-term results of endoscopic balloon dilatation of lower gastrointestinal tract strictures in Crohn's disease:A prospective study显示文摘AIM:To examine the long-term results of endoscopic treatment in a prospective study conducted over a period of 10 years,1997 to January 2007.METHODS:A total of 25 patients(20 female and five male:aged 18-75 years),with at least one symptom of stricture not passable with the standard colonoscope and with a confirmed scarred Crohn's stricture of the lower gastrointestinal tract,were included in the study.The main symptom was abdominal pain.The endoscopic balloon dilatation was performed with an 18 mm balloon under endoscopic and radiological control.RESULTS:Eleven strictures were located in the colon,13 at the anastomosis after ileocecal resection,three at the Bauhin valve and four in the ileum.Four patients had two strictures and one patient had three strictures.Of the 31 strictures,in 30 was balloon dilatation successful in a single endoscopic session,so that eventually the strictures could be passed easily with the standard colonoscope.In one patient with a long stricture of the ileum involving the Bauhin valve and an additional stricture of the ileum which were 15 cm apart,sufficient dilatation was not possible.This patient therefore required surgery.Improvement of abdominal symptoms was achieved in all cases which had technically successful balloon dilatation,althoughin one case perforation occurred after dilatation of a recurrent stricture.Available follow-up was in the range of 54-118 mo(mean of 81 mo).The relapse rate over this period was 46%,but 64% of relapsing strictures could be successfully dilated again.Only in four patients was surgery required during this follow-up period.CONCLUSION:We conclude from these initial results that endoscopic balloon dilatation,especially for short strictures in Crohn's disease,can be performed with reliable success.Perforation is a rare complication.It is our opinion that in the long-term,the relapse rate is probably higher than after surgery,but usually a second endoscopic treatment can be performed successfully,leading to a considerable success rate of the endoscopic procedure. | Klaus Stienecker Daniel Gleichmann Ulrike Neumayer H Joachim Glaser Carolin Tonus | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 9 | 河北安固里淖孢粉记录的晚冰期以来的植被演替与气候变化显示文摘河北安固里淖地处东南季风的边缘地区,是研究古气候环境演化的理想地区之一。文章以安固里淖的沉积岩芯(长18.4 m)为研究对象,利用AMS 14C测年和孢粉数据,重建了安固里淖湖区14.3 cal.ka B.P.以来的植被与气候演化历史。结果表明:14.3~11.0 cal.ka B.P.期间,湖区以疏林草原植被为主,气候偏干;11.0~6.0 cal.ka B.P.以森林草原植被为主,气候湿润;6.0~3.2 cal.ka B.P.以疏林草原植被为主,气候偏湿;3.2~0 cal.ka B.P.以荒漠草原植被为主,气候干旱。总体而言,自晚冰期以来安固里淖的气候经历了由干变湿再逐渐变干的过程,全新世适宜期出现在早中全新世。通过区域对比发现,安固里淖揭示的晚冰期以来东南季风的气候演化特征与西南季风的演化具有很大的相似性,表明晚冰期以来东南季风与西南季风在轨道尺度上的演化并无太大差异,太阳辐射是二者演化的共同驱动力。 | 齐惠慧 刘兴起 李华淑 李峻峰 曹现勇 Ulrike Herzschuh | 2018 | 第四纪研究2018，38，5： | 9 |
| 10 | Dental and periodontal phenotype in sclerostin knockout mice显示文摘Sclerostin is a Wnt signalling antagonist that controls bone metabolism.Sclerostin is expressed by osteocytes and cementocytes;however,its role in the formation of dental structures remains unclear.Here,we analysed the mandibles of sclerostin knockout mice to determine the influence of sclerostin on dental structures and dimensions using histomorphometry and micro-computed tomography(mCT)imaging.mCT and histomorphometric analyses were performed on the first lower molar and its surrounding structures in mice lacking a functional sclerostin gene and in wild-type controls.mCT on six animals in each group revealed that the dimension of the basal bone as well as the coronal and apical part of alveolar part increased in the sclerostin knockout mice.No significant differences were observed for the tooth and pulp chamber volume.Descriptive histomorphometric analyses of four wild-type and three sclerostin knockout mice demonstrated an increased width of the cementum and a concomitant moderate decrease in the periodontal space width.Taken together,these results suggest that the lack of sclerostin mainly alters the bone and cementum phenotypes rather than producing abnormalities in tooth structures such as dentin. | Ulrike Kuchler Uwe Y Schwarze Toni Dobsak Patrick Heimel Dieter D Bosshardt Michaela Kneissel Reinhard Gruber | 2014 | International Journal of Oral Science2014，6，2： | 7 |
| 11 | Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker显示文摘AIM: To evaluate the diagnostic and prognostic value of circulating Metastasis Associated in Colon Cancer 1(MACC1) transcripts in plasma of gastric cancer patients.METHODS: We provide for the first time a blood-based assay for transcript quantification of the metastasis inducer MACC1 in a prospective study of gastric cancer patient plasma.MACC1 is a strong prognostic biomarker for tumor progression and metastasis in a variety of solid cancers.We conducted a study to define the diagnostic and prognostic power of MACC1 transcripts using 76 plasma samples from gastric cancer patients,either newly diagnosed with gastric cancer,newly diagnosed with metachronous metastasis of gastric cancer,as well as follow-up patients.Findings were controlled by using plasma samples from 54 tumor-free volunteers.Plasma was separated,RNA was isolated,and levels of MACC1 as well as S100A4 transcripts were determined by quantitative RT-PCR.RESULTS: Based on the levels of circulating MACC1 transcripts in plasma we significantly discriminated tumorfree volunteers and gastric cancer patients(P < 0.001).Levels of circulating MACC1 transcripts were increased in gastric cancer patients of each disease stage,compared to tumor-free volunteers: patients with tumors without metastasis(P = 0.005),with synchronous metastasis(P = 0.002),with metachronous metastasis(P = 0.005),and patients during follow-up(P = 0.021).Sensitivity was 0.68(95%CI: 0.45-0.85) and specificity was 0.89(95%CI: 0.77-0.95),respectively.Importantly,gastric cancer patients with high circulating MACC1 transcript levels in plasma demonstrated significantly shorter survival whencompared with patients demonstrating low MACC1 levels(P = 0.0015).Furthermore,gastric cancer patients with high circulating transcript levels of MACC1 as well as of S100A4 in plasma demonstrated significantly shorter survival when compared with patients demonstrating low levels of both biomarkers or with only one biomarker elevated(P = 0.001).CONCLUSION: Levels of circulating MACC1 transcripts in plasma of gastric cancer patients are of diagnostic value and are prognostic for patient survival in a prospective study. | Susen Burock Pia Herrmann Ina Wendler Markus Niederstrasser Klaus-Dieter Wernecke Ulrike Stein | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 12 | 公共产业技术研究院促进区域创新发展显示文摘在新世纪的第二个十年,北京要实现以"创新驱动发展"转变经济发展方式、建设成为国家创新中心的重大目标,一定需要一批以应用研究与创新为核心目标、产学研紧密结合、充分发挥业界"技术支援机构"作用的公共产业技术研究院。本系列文章基于全球视野,总结了其他国家和地区较具代表性的此类机构的创新驱动作用和管理模式,对当前建立和完善首都区域创新体系具有重要的参考意义。 | 冷民 Ulrike Tagscherer 徐秋慧 | 2011 | 科技潮2011，，4： | 7 |
| 13 | Correlation analysis of dual-energy CT iodine maps with quantitative pulmonary perfusion MRI显示文摘AIM:To correlate dual-energy computed tomography(DECT) pulmonary angiography derived iodine maps with parameter maps of quantitative pulmonary perfusion magnetic resonance imaging(MRI).METHODS:Eighteen patients with pulmonary perfusion defects detected on DECT derived iodine maps were included in this prospective study and additionally underwent time-resolved contrast-enhanced pulmonary MRI [dynamic contrast enhanced(DCE)-MRI].DCE-MRI data were quantitatively analyzed using a pixel-by-pixel deconvolution analysis calculating regional pulmonary blood flow(PBF),pulmonary blood volume(PBV) and mean transit time(MTT) in visually normal lung parenchyma and perfusion defects.Perfusion parameterswere correlated to mean attenuation values of normal lung and perfusion defects on DECT iodine maps.Two readers rated the concordance of perfusion defects in a visual analysis using a 5-point Likert-scale(1 = no correlation,5 = excellent correlation).RESULTS:In visually normal pulmonary tissue mean DECT and MRI values were:22.6 ± 8.3 Hounsfield units(HU);PBF:58.8 ± 36.0 mL/100 mL per minute;PBV:16.6 ± 8.5 mL;MTT:17.1 ± 10.3 s.In areas with restricted perfusion mean DECT and MRI values were:4.0 ± 3.9 HU;PBF:10.3 ± 5.5 mL/100 mL per minute,PBV:5 ± 4 mL,MTT:21.6 ± 14.0 s.The differences between visually normal parenchyma and areas of restricted perfusion were statistically significant for PBF,PBV and DECT(P < 0.0001).No linear correlation was found between MRI perfusion parameters and attenuation values of DECT iodine maps(PBF:r = 0.35,P = 0.15;PBV:r = 0.34,P = 0.16;MTT:r = 0.41,P = 0.08).Visual analysis revealed a moderate correlation between perfusion defects on DECT iodine maps and the parameter maps of DCE-MRI(mean score 3.6,k 0.45).CONCLUSION:There is a moderate visual but not statistically significant correlation between DECT iodine maps and perfusion parameter maps of DCE-MRI. | Jan Hansmann Paul Apfaltrer Frank G Zoellner Thomas Henzler Mathias Meyer Gerald Weisser Stefan O Schoenberg Ulrike I Attenberger | 2013 | World Journal of Radiology2013，5，5： | 6 |
| 14 | Rheumatic fever reappraised显示文摘Rheumatic fever is a complication following an episode of group A streptococcal pharyngitis. It is an acute immunologically mediated, multisystem inflammatory disorder. Acute rheumatic heart disease during the active phase of rheumatic fever sometimes progresses to chronic rheumatic heart disease. Despite its declining importance in industrialised countries rheumatic fever remains the leading cause of death from heart disease in children and young adults in less developed regions. Fifteen to twenty million new cases emerge every year in developing countries. | Ulrik Baandrup | 2005 | Chinese Medical Journal2005，，5： | 6 |
| 15 | Species of the Colletotrichum gloeosporioides complex associated with anthracnose diseases of Proteaceae显示文摘Anthracnose disease of Proteaceae has in the past chiefly been attributed to infections by C.acutatum,C.boninense and C.gloeosporioides.In the present study,a multi-locus phylogenetic analysis(ACT,CAL,CHS-1,GAPDH,GS,ITS,TUB2)revealed that strains of the C.gloeosporioides complex associated with Proteaceae belong to at least six species.These include C.alienum,C.aotearoa,C.kahawae(subsp.ciggaro),C.siamense,and two new taxa,C.proteae and C.grevilleae.The most economically important pathogen of Proteaceae seems to be C.alienum,and not C.gloeosporioides as previously reported.All taxa associated with Proteaceae are morphologically described on different media in culture,except strains of C.siamense,which proved to be sterile.Furthermore,C.populi is synonymised with C.aenigma. | Fang Liu Ulrike Damm Lei Cai Pedro W.Crous | 2013 | Fungal Diversity2013，，4： | 6 |
| 16 | First case report of exacerbated ulcerative colitis after anti-interleukin-6R salvage therapy显示文摘We present the case of a 53-year-old woman with long-standing ulcerative colitis and severe, steroid-dependent disease course unresponsive to treatment with azathioprine, methotrexate, anti-TNF antibodies(infliximab, adalimumab) and tacrolimus, who refused colectomy as a therapeutic option. As the pro-inflammatory cytokine interleukin-6(IL-6) had been identified as a crucial regulator in the immunopathogenesis of inflammatory bowel diseases, we treated the patient with biweekly intravenous infusions of an anti-IL-6R antibody(tocilizumab) for 12 wk. However, no clinical improvement of disease activity was noted. In fact, endoscopic, histological and endomicroscopic assessment demonstrated exacerbation of mucosal inflammation and ulcer formation upon anti-IL-6R therapy. Mechanistic studies revealed that tocilizumab treatment failed to suppress intestinal IL-6 production, impaired epithelial barrier function and induced production of pro-inflammatory cytokines such as TNF, IL-21 and IFN-γ. Inhibition of IL-6 by tocilizumab had no clinical benefit in this patient with intractable ulcerative colitis and even led to exacerbation of mucosal inflammation. Our findings suggest that anti-IL-6R antibody therapy may leadto aggravation of anti-TNF resistant ulcerative colitis. When targeting IL-6, the differential responsiveness of target cells has to be taken into account, as IL-6 on the one side promotes acute and chronic mucosal inflammation via soluble IL-6R signaling but on the other side also strongly contributes to epithelial cell survival via membrane bound IL-6R signaling. | Raja Atreya Ulrike Billmeier Timo Rath Jonas Mudter Michael Vieth Helmut Neumann Markus F Neurath | 2015 | World Journal of Gastroenterology2015，21，45： | 5 |
| 17 | 中国现代花粉数据集显示文摘孢粉是重建古植被、古气候的重要基础数据。孢粉数据库对研究样点至区域和全球尺度上的古环境演变规律、古气候变化特征反演和古生物地球化学循环模拟等具有重要意义。该文收集整理了中国1960–2020年间发表和部分未发表的现代花粉数据记录,包括样品编号、采样位置、采样地经纬度和海拔高度、样品类型、数据来源、数据类型、周边植被信息、参考文献、花粉类群及其含量等信息;并对数据进行筛选和标准化等处理,由此整合为中国现代花粉数据集。该数据集由4 497个现代花粉采样点的数据信息组成,包括660个来自中国第四纪孢粉数据库数据,1 763个前期整理发表的数据和2 074个近期收集的数据,涵盖772个花粉类群。样品类型以土壤表层样品(3 332个)为主,苔藓样品以及湖泊、海洋表层样品等为辅,广泛分布于全国不同地理区域和植被类型中,其中以温带荒漠区域(24.91%)和亚热带常绿阔叶林区域(24.02%)最丰富,其次为温带草原区域(16.14%)和青藏高原高寒植被区域(15.83%)。数据按照来源可分为原始数据(58%)和数值化数据(42%);按照数据类型可分为原始统计粒数的样点(59%)和以花粉百分比表达的样点(41%)。半个多世纪以来,科研人员开展了大量的表层现代花粉取样和研究。本数据集虽然仅获取部分记录,但样点覆盖了我国绝大多数地区,可有效地用于古植被与古气候重建的现代孢粉与现代植被校验,并将为中国孢粉数据库的建立与更深入的孢粉研究提供数据支撑。 | 陈海燕 徐德宇 廖梦娜 李凯 倪健 曹现勇 程波 郝秀东 孔昭宸 李升峰 李小强 刘光琇 刘平妹 刘兴起 孙湘君 唐领余 魏海成 许清海 阎顺 羊向东 杨振京 于革 张芸 张志勇 赵克良 郑卓 Ulrike HERZSCHUH | 2021 | 植物生态学报2021，45，7： | 5 |
| 18 | Feasibility study of computed vs measured high b-value(1400 s/mm2) diffusion-weighted MR images of the prostate显示文摘AIM: To evaluate the impact of computed b = 1400 s/mm2(C-b1400) vs measured b = 1400 s/mm2(M-b1400) diffusion-weighted images(DWI) on lesion detection rate, image quality and quality of lesion demarcation using a modern 3T-MR system based on a small-field-of-view sequence(sFOV). METHODS: Thirty patients(PSA: 9.5 ± 8.7 ng/mL; 68 ± 12 years) referred for magnetic resonance imaging(MRI) of the prostate were enrolled in this study. All measurements were performed on a 3T MR system.For DWI, a single-shot EPI diffusion sequence(b = 0, 100, 400, 800 s/mm2) was utilized. C-b1400 was cal-culated voxelwise from the ADC and diffusion images. Additionally, M-b1400 was acquired for evaluation and comparison. Lesion detection rate and maximum lesion diameters were obtained and compared. Image quality and quality of lesion demarcation were rated accord-ing to a 5-point Likert-type scale. Ratios of lesion-to-bladder as well as prostate-to-bladder signal intensity(SI) were calculated to estimate the signal-to-noise-ratio(SNR). RESULTS: Twenty-four lesions were detected on M-b1400 images and compared to C-b1400 images. C-b1400 detected three additional cancer suspicious lesions. Overall image quality was rated significantly better and SI ratios were significantly higher on C-b1400(2.3 ± 0.8 vs 3.1 ± 1.0, P < 0.001; 5.6 ± 1.8 vs 2.8 ± 0.9, P < 0.001). Comparison of lesion size showed no significant differences between C- and M-b1400(P = 0.22). CONCLUSION: Combination of a high b-value extrap-olation and sFOV may contribute to increase diagnostic accuracy of DWI without an increase of acquisition time, which may be useful to guide targeted prostate biopsies and to improve quality of multiparametric MRI(mMRI) especially under economical aspects in a pri-vate practice setting. | Leonardo K Bittencourt Ulrike I Attenberger Daniel Lima Ralph Strecker Andre de Oliveira Stefan O Schoenberg Emerson L Gasparetto Daniel Hausmann | 2014 | World Journal of Radiology2014，6，6： | 5 |
| 19 | Who makes acquisitions? CEO overconfidence and the market’s reaction显示文摘 | Ulrike Malmendier Geoffrey Tate | 2008 | Journal of Financial Economics2008，，1： | 5 |
| 20 | 中国旅游发展笔谈——旅游信息技术研究前沿显示文摘信息技术与旅游的关系正在成为旅游研究中的热门话题。认识和厘清这个关系面临着两个主要挑战:一方面,旅游本身是庞大芜杂的行业,也是复杂的社会、经济和文化现象;另一方面,信息技术日新月异,对科研人员来说,是一个'移动的目标'。因此,如何把握信息技术和旅游的重要结合点,既体现旅游的本质和特征,又反映时代脉搏和对未来的展望,值得旅游科研工作者深思。 | Ulrike GRETZEL 向征(译) 丁于思(校) | 2020 | 旅游学刊2020，35，1： | 5 |
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