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| 1 | Introducing an enhanced recovery after surgery program in colorectal surgery:A single center experience显示文摘AIM:To study the implementation of an enhanced recovery after surgery(ERAS)program at a large University Hospital from'pilot study'to'standard of care'.METHODS:The study was designed as a prospective single centre cohort study.A prospective evaluation of compliance to a protocol based on full application of all ERAS principles,through the progressive steps of its implementation,was performed.Results achieved in the initial pilot study conducted by a dedicated team(n=47)were compared to those achieved in the shared protocol phase(n=143)three years later.Outcomes were length of postoperative hospital stay,readmission rate,compliance to the protocol and morbidity.Primary endpoint was the description of the results and the identification of critical issues of large scale implementation of an ERAS program in colorectal surgery emerged in the experience of a single center.Secondary endpoint was the identification of interventions that have been proven to be effective for facilitating the transition from traditional care pathways to a multimodal management protocol according to ERAS principles in colorectal surgery at a single center.RESULTS:During the initial pilot study(March 2009 to December 2010;47 patients)conducted by a dedicated multidisciplinary team,compliance to the items of ERAS protocol was 93%,with a median length of hospital stay(LOS)of 3 d.Early anastomotic fistulas were observed in 2 cases(4.2%),which required reoperation(Clavien-Dindo gradeⅢb).None of the patients had been discharged before the onset of the complication,which could therefore receive prompt treatment.There were also four(8.5%)minor complications(ClavienDindo gradeⅡ).Thirty days readmission rate was 4%.Perioperative mortality was nil.After implementation of the protocol throughout the Hospital in unselected patients(May 2012 to December 2012;147 patients)compliance was 74%,with a median LOS of 6 d.Early anastomotic fistulas were observed in 11 cases(7.7%),5(3.5%)of which required reoperation(Clavien-Dindo gradeⅢb).Two early anastomotic fistulas were treated by radiologic/endoscopic manoeuvres and 4 were treated conservatively.There were also 36(25.2%)minor complications,21(14.7%)of which were Clavien-Dindo gradeⅡand 15(10.5%)of which were Clavien-Dindo gradeⅠ.Only two patients whose course was adversely affected by the development of an anastomotic leak had been discharged before the onset of the complication itself,requiring readmission.Readmission rate within 30 d was 4%.Perioperative mortality was 1%.CONCLUSION:Our results confirm that introduction of an ERAS protocol for colorectal surgery allows quickerpostoperative recovery and shortens the length of stay compared to historical series. | Stefano Bona Mattia Molteni Riccardo Rosati Ugo Elmore Pietro Bagnoli Roberta Monzani Monica Caravaca Marco Montorsi | 2014 | World Journal of Gastroenterology2014，20，46： | 30 |
| 2 | Gastric cancer: Current status of lymph node dissection显示文摘D2 procedure has been accepted in Far East as the standard treatment for both early(EGC) and advanced gastric cancer(AGC) for many decades. Recently EGC has been successfully treated with endoscopy by endoscopic mucosal resection or endoscopic submucosal dissection, when restricted or extended Gotoda's criteria can be applied and D1+ surgery is offered only to patients not fitted for less invasive treatment. Furthermore, two randomised controlled trials(RCTs) have been demonstrating the non inferiority of minimally invasive technique as compared to standard open surgery for the treatment of early cases and recently the feasibility of adequate D1+ dissection has been demonstrated also for the robot assisted technique. In case of AGC the debate on the extent of nodal dissection has been open for many decades. While D2 gastrectomy was performed as the standard procedure in eastern countries, mostly based on observational and retrospective studies, in the west the Medical Research Council(MRC), Dutch and Italian RCTs have been conducted to show a survival benefit of D2 over D1 with evidence based medicine. Unfortunately both the MRC and the Dutch trials failed to show a survival benefit after the D2 procedure, mostly due to the significant increase of postoperative morbidity and mortality, which was referred to splenopancreatectomy. Only 15 years after the conclusion of its accrual, the Dutch trial could report a significant decrease of recur-rence after D2 procedure. Recently the long term survival analysis of the Italian RCT could demonstrate a benefit for patients with positive nodes treated with D2 gastrectomy without splenopancreatectomy. As nowadays also in western countries D2 procedure can be done safely with pancreas preserving technique and without preventive splenectomy, it has been suggested in several national guidelines as the recommended procedure for patients with AGC. | Maurizio Degiuli Giovanni De Manzoni Alberto Di Leo Domenico D'Ugo Erica Galasso Daniele Marrelli Roberto Petrioli Karol Polom Franco Roviello Francesco Santullo Mario Morino | 2016 | World Journal of Gastroenterology2016，22，10： | 29 |
| 3 | International consensus statement on robotic hepatectomy surgery in 2018显示文摘The robotic surgical system has been applied in liver surgery. However,controversies concerns exist regarding a variety of factors including the safety,feasibility, efficacy, and cost-effectiveness of robotic surgery. To promote the development of robotic hepatectomy, this study aimed to evaluate the current status of robotic hepatectomy and provide sixty experts' consensus and recommendations to promote its development. Based on the World Health Organization Handbook for Guideline Development, a Consensus Steering Group and a Consensus Development Group were established to determine the topics, prepare evidence-based documents, and generate recommendations. The GRADE Grid method and Delphi vote were used to formulate the recommendations. A total of 22 topics were prepared analyzed and widely discussed during the 4 meetings. Based on the published articles and expert panel opinion, 7 recommendations were generated by the GRADE method using an evidence-based method, which focused on the safety, feasibility, indication,techniques and cost-effectiveness of hepatectomy. Given that the current evidences were low to very low as evaluated by the GRADE method, further randomized-controlled trials are needed in the future to validate these recommendations. | Rong Liu Go Wakabayashi Hong-Jin Kim Gi-Hong Choi Anusak Yiengpruksawan Yuman Fong Jin He Ugo Boggi Roberto I Troisi Mikhail Efanov Daniel Azoulay Fabrizio Panaro Patrick Pessaux Xiao-Ying Wang Ji-Ye Zhu Shao-Geng Zhang Chuan-Dong Sun Zheng Wu Kai-Shan Tao Ke-Hu Yang Jia Fan Xiao-Ping Chen | 2019 | World Journal of Gastroenterology2019，25，12： | 23 |
| 4 | Neo-adjuvant chemo(radio)therapy in gastric cancer: Current status and future perspectives显示文摘In the last 20 years, several clinical trials on neoadjuvant chemotherapy and chemo-radiotherapy as a therapeutic approach for locally advanced gastric cancer have been performed. Even if more data are necessary to define the roles of these approaches, the results of preoperative treatments in the combined treatment of gastric adenocarcinoma are encouraging because this approach has led to a higher rate of curative surgical resection. Owing to the results of most recent randomized phase III studies, neoadjuvant chemotherapy for locally advanced resectable gastric cancer has satisfied the determination of level I evidence. Remaining concerns pertain to the choice of the optimal therapy regimen, strict patient selection by accurate pre-operative staging, standardization of surgical procedures, and valid criteria for response evaluation. New well-designed trials will be necessary to find the best therapeutic approach in pre-operative settings and the best way to combine old-generation chemotherapeutic drugs with new-generation molecules. | Alberto Biondi Maria C Lirosi Domenico D'Ugo Valeria Fico Riccardo Ricci Francesco Santullo Antonia Rizzuto Ferdinando CM Cananzi Roberto Persiani | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 13 |
| 5 | 经尺动脉途径介入治疗冠心病术后半年平板运动试验评估心功能显示文摘目的:观察经尺动脉途径介入治疗冠心病术后半年平板运动试验对心功能的评估结果,比较经尺动脉途径和经桡动脉途径介入治疗的可行性。方法:在10例患者中应用经尺动脉途径成功7例,其中5例为冠脉造影,2例为支架植入,与经桡动脉途径病例105例进行比较,并对两组患者中接受经皮腔内冠状动脉成形术(percutaneoustransluminalcoronaryangioplasty,PTCA)及支架植入者进行随访,同时应用活动平板运动试验评估患者心功能情况。结果:经桡动脉途径与经尺动脉途径穿刺及导管操作的平均时间犤冠状动脉造影(60±30)min,PCI(83±24)min犦差异无显著性意义。冠状动脉造影及支架植入的成功率经两种途径差异无显著性意义。7例患者中没有并发症发生,术后随访平板运动试验评价的心功能均得到改善。结论:尺动脉可作为另一个可行的冠状动脉诊断和治疗途径,同时可保留桡动脉用于做外科冠脉搭桥。经尺动脉途径介入治疗冠心病后通过活动平板运动试验检测发现,此种术式能显著改善患者术后的心功能。 | 孙玲 郭群萍 李艳华 王玲 孙晓东 张迪 Limbruno Ugo | 2003 | 中国临床康复2003，7，24： | 11 |
| 6 | 全球法与掠夺:法治的阴暗面显示文摘'法治'(rule of law),习惯上已被当作一个具有积极本质、政治中立的'工具',且效力普适,放之四海而皆准。作为Ugo Mattei与Laura Nadar教授合著的Plunder:When the Ruleof Law is Illegal(Blackwell Publishing,Oxford 2008)一书观点的综述,本文认为,作为一个歧义丛生的概念,'法治'具有光明与阴暗的两面性,而'法治'的阴暗面长期以来一直被排除在公众讨论的范围之外。'法治'作为一个华丽辞藻,已被西方强势者所挟持,用来论证其(主要)对'发展中'国家的干涉及其最终演变成的掠夺(plunder)实践的合法性,并使西方经济势力对'非西方世界'(the rest)的扩张成为可能。基于此,我们得出了这样的结论:'法治'已被'非法地'(illegally)利用。目前国际金融机构——当今的全球立法者——在用'法治'观念包裹着其提供给'发展中世界'的各种改革方案的背后,隐藏着智识短视、种族中心主义和帝国主义立场。'技术性'概念对'法'概念的偷换,美国法所独享的全球性支配地位以及当今西方跨国公司的帝国主义态度等作为其中的一些指标,向我们展示了殖民主义与当今新自由主义政策之间的沆瀣一气。 | Ugo Mattei Marco de Morpurgo 刘光华(译) | 2010 | 兰州大学学报(社会科学版)2010，38，3： | 10 |
| 7 | Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase显示文摘Mitogen-activated protein kinases(MAPKs)are a family of proteins that constitute signaling pathways involved in processes that control gene expression,cell division, cell survival,apoptosis,metabolism,differentiation and motility.The MAPK pathways can be divided into conventional and atypical MAPK pathways.The first group converts a signal into a cellular response through a relay of three consecutive phosphorylation events exerted by MAPK kinase kinases,MAPK kinase,and MAPK.Atypical MAPK pathways are not organized into this three-tiered cascade.MAPK that belongs to both conventional and atypical MAPK pathways can phosphorylate both non-protein kinase substrates and other protein kinases.The latter are referred to as MAPK-activated protein kinases.This review focuses on one such MAPK-activated protein kinase,MAPK-activated protein kinase 5(MK5)or p38-regulated/activated protein kinase(PRAK).This protein is highly conserved throughout the animal kingdom and seems to be the target of both conventional and atypical MAPK pathways.Recent findings on the regulation of the activity and subcellular localization,bona fide interaction partners and physiological roles of MK5/PRAK are discussed. | Sergiy Kostenko Gianina Dumitriu Kari Jenssen Lgreid Ugo Moens | 2011 | World Journal of Biological Chemistry2011，2，5： | 8 |
| 8 | 温室白粉虱的生物学研究显示文摘本文报道了有关温室白粉虱Trialeurodes vaporariorum Westwood的生特学特性。根据我们的初步观察,温室白粉虱的变态类型更近于完全变态,因此,其幼虫期称为“幼虫”要比“若虫”更合适。在20℃温度下完成一个世代需要33d,25℃条件下为19d。植物的生育期对产卵量的影响显著,但对从卵孵化后发育至成虫的成活率无明显影响,温室白粉虱的交尾频率在早晨与傍晚较高,扩散方向受温室灯光影响。 | 黄耀阁 鄢淑琴 史树森 UGO CIRIO | 1993 | 吉林农业大学学报1993，15，2： | 6 |
| 9 | Cystic echinococcosis of the liver and lung treated by radiofrequency thermal ablation:An ex-vivo pilot experimental study in animal models显示文摘AIM:To evaluate radiofrequency thermal ablation (RTA) for treatment of cystic echinococcosis in animal models (explanted organs).METHODS:Infected livers and lungs from slaughtered animals,10 bovine and two ovine,were collected.Cysts were photographed,and their volume,cyst content,germinal layer adhesion status,wall calcification and presence of daughter or adjacent cysts were evaluated by ultrasound.Some cysts were treated with RTA at 150 W,80℃,7 min.Temperature was monitored inside and outside the cyst.A second needle was placed inside the cyst for pressure stabilization.After treatment,all cysts were sectioned and examined by histology.Cysts were defined as alive if a preserved germinal layer at histology was evident,and as successfully treated if the germinal layer was necrotic.RESULTS:The subjects of the study were 17 cysts (nine hepatic and eight pulmonary),who were treated with RTA.Pathology showed 100% success rate in both hepatic (9/9) and lung cysts (8/8);immediate volume reduction of at least 65%;layer of host tissue necrosis outside the cyst,with average extension of 0.64 cm for liver and 1.57 cm for lung;and endocyst attached to the pericystium both in hepatic and lung cysts with small and focal de novo endocyst detachment in just 3/9 hepatic cysts.CONCLUSION:RTA appears to be very effective in killing hydatid cysts of explanted liver and lung.Bile duct and bronchial wall necrosis,persistence of endocyst attached to pericystium,should help avoid or greatly decrease in vivo post-treatment fistula occurrence and consequent overlapping complications that are common after surgery or percutaneous aspiration,injection and reaspiration.In vivo studies are required to confirm and validate this new therapeutic approach. | Vincenzo Lamonaca Antonino Virga Marta Ida Minervini Roberta Di Stefano Alessio Provenzani Pietro Tagliareni Giovanna Fleres Angelo Luca Giovanni Vizzini Ugo Palazzo Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，26： | 6 |
| 10 | Rethinking the Barcelona clinic liver cancer guidelines:Intermediate stage and Child-Pugh B patients are suitable for surgery?显示文摘According to Barcelona Clinic Liver Cancer recommendations,intermediate stage hepatocellular carcinomas(stage B)are excluded from liver resection and are referred to palliative treatment.Moreover,Child-Pugh B patients are not usually candidates for liver resection.However,many hepatobiliary centers in the world manage patients with intermediate stage hepatocellular carcinoma or Child-Pugh B cirrhosis with liver resection,maintaining that hepatic resection is not contraindicated in selected patients with non–early-stage hepatocellular carcinoma and without normal liver function.Several studies demonstrate that resection provides the best survival benefit for selected patients in very early/early and even in intermediate stages of Barcelona Clinic Liver Cancer classification,and this treatment gives good results in the setting of multinodular,large tumors in patients with portal hypertension and/or Child-Pugh B cirrhosis.In this review we explore this controversial topic,and we show through the literature analysis how liver resection may improve the short-and long-term survival rate of carefully selected Barcelona Clinic Liver Cancer B and Child-Pugh B hepatocellular carcinoma patients.However,other large clinical studies are needed to clarify which patients with intermediate stage hepatocellular carcinoma are most likely to benefit from liver resection. | Fabrizio Romano Marco Chiarelli Mattia Garancini Mauro Scotti Mauro Zago Gerardo Cioffi Matilde De Simone Ugo Cioffi | 2021 | World Journal of Gastroenterology2021，27，21： | 5 |
| 11 | R0 resection in the treatment of gastric cancer:Room for improvement显示文摘Gastric carcinoma is one of the most frequent malignancies in the world and its clinical behavior especially depends on the metastatic potential of the tumor.In particular,lymphatic metastasis is one of the main predictors of tumor recurrence and survival,and current pathological staging systems reflect the concept that lymphatic spread is the most relevant prognostic factor in patients undergoing curative resection.This is compounded by the observation that two-thirds of gastric cancer in the Western world presents at an advanced stage,with lymph node metastasis at diagnosis.All current therapeutic efforts in gastric cancer are directed toward individualization of therapeutic protocols,tailoring the extent of resection and the administration of preoperative and postoperative treatment.The goals of all these strategies are to improve prognosis towards the achievement of a curative resection(R0 resection) with minimal morbidity and mortality,and better postoperative quality of life. | Alberto Biondi Roberto Persiani Ferdinando Cananzi Marco Zoccali Vincenzo Vigorita Andrea Tufo Domenico D'Ugo | 2010 | World Journal of Gastroenterology2010，16，27： | 4 |
| 12 | 3D additive-manufactured nanocomposite magnetic scaffolds: Effect of the application mode of a time-dependent magnetic field on hMSCs behavior显示文摘Over the past few years,the influence of static or dynamic magnetic fields on biological systems has become a topic of considerable interest.Magnetism has recently been implicated to play significant roles in the regulation of cell responses and,for this reason,it is revolutionizing many aspects of healthcare,also suggesting new opportunities in tissue engineering.The aim of the present study was to analyze the effect of the application mode of a time-dependent magnetic field on the behavior of human mesenchymal stem cells(hMSCs)seeded on 3D additivemanufactured poly(3-caprolactone)/iron-doped hydroxyapatite(PCL/FeHA)nanocomposite scaffolds. | Ugo D'Amora Teresa Russo Antonio Gloria Virginia Rivieccio Vincenzo D'Anto Giacomo Negri Luigi Ambrosio Roberto De Santis | 2017 | Bioactive Materials2017，2，3： | 3 |
| 13 | Changing trends in corneal graft surgery: a ten-year review显示文摘AIM:To review indications and corneal tissue use for penetrating and lamellar surgery between 2002 and 2011.·METHODS:The surgical reports of corneal grafts performed during 2002-2011,using tissues supplied by the Eye Bank of Piedmont(Italy),were reviewed retrospectively.Patient demographic data,date of intervention,indication for surgery,and surgical technique used were recorded.Surgical techniques included penetrating keratoplasty(PK),deep anterior lamellar keratoplasty(DALK)and endothelial keratoplasty(EK).Theχ2test was used to compare the distribution of indications and types of surgical technique used,for corneal grafts done during 2002-2006 versus those done during 2007-2011.·RESULTS:The number of corneal grafts increased by30.7%from 2002-2006 to 2007-2011(from 1567 to 2048).Comparing the two periods,both main indications and surgical techniques changed significantly.In 2007-2011,the proportion of interventions for aphakic/pseudophakic bollous keratopathy(from 16.8%to 21.3%),graft failure(from 16.4%to 19.1%)and Fuchs endothelial dystrophy(from 12.8%to 16.7%)all increased significantly(P<0.05),while those for keratoconus decreased significantly(from35.6%to 27.3%;P<0.001).In 2007-2011,the proportion of PK decreased significantly(from 92.4%to 57.2%;P<0.001)while that of EK and DALK went from 0.4%to30.2%(P<0.001)and from 7.2%to 12.6%(P<0.001)respectively.·CONCLUSION:During 2002-2011 the number of interventions increased significantly for corneal endothelial diseases and graft failure.The growing demand for interventions for these diseases corresponded to the widespread adoption of EK techniques.The use of DALK also increased,but more moderately than EK procedures. | Ugo de Sanctis camilla alovisi Luigi Bauchiero Guido Caramello Gianfranco Girotto Claudio Panico Luisa Vinai Federico Genzano Antonio Amoroso federico grignolo | 2016 | International Journal of Ophthalmology(English edition)2016，9，1： | 3 |
| 14 | Capital account liberalization, financial development and industry growth: A synthetic view显示文摘 | Barry Eichengreen Rachita Gullapalli Ugo Panizza | 2011 | Journal of International Money and Finance2011，，6： | 3 |
| 15 | Laparoscopic splenectomy for a littoral cell angioma of the spleen: Case report显示文摘A littoral cell angioma(LCA) is a primary vascular tumor of the spleen, that can have malignant potential and may present association with other malignancies. This is a case of LCA that was discovered incidentally in a 79-year-old woman who presented with a polycythemia at the time of consultation. The neoplasm was evaluated by ultrasound and computed tomography. The patient underwent a splenectomy that revealed LCA by pathological evaluation. The post-operative outcome was favorable with no complications or recurrent disease. This case presentation, clinical, radiographic, and pathological features of an uncommon splenic tumor can be studied in order to advance our knowledge in our understanding of LCA. | Alice Marzetti Federico Messina Daniela Prando Luca A Verza Ugo Vacca Alireza Azabdaftari Leonardo Rubinato Domenico Reale Massimo Favat Mario Barbujani Ferdinando Agresta | 2015 | World Journal of Clinical Cases2015，3，11： | 3 |
| 16 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 17 | 冠心病介入操作途径对比研究显示文摘目的:经桡动脉途径(TRA)近来已被作为一种冠心病介入治疗的新途径,现将在欧洲的TRA的病例与在中国经股动脉途径(TFA)的病例进行可行性、安全性和有效性比较,同时将两组人群的病变程度进行比较。方法:选择在比萨大学心胸科的病例1300人作为A组[包括195名因TRA失败而经肱动脉和股动脉的病例(15%)]。B组由400名来自中国北方某一城市TFA行冠心病介入诊断和治疗的病例。A组中应用了冠脉血管内超声、压力导丝、切割球囊和放射治疗等技术。C组包括50例中国该城市2003年TRA冠脉介入诊断和治疗的病例。结果:冠心病介入诊断和治疗人群发生率A组明显高于B组(P<0.01)。A组病人病变较B组严重,手术过程也较B组复杂。平均操作时间在B组和A组分别为冠脉造影(30±5)和(50±5)min,介入治疗(65±2)和(81±4)min(P<0.01)。在A组病例中,有20例急性心肌梗死的病人成功地接受了直接PTCA和支架植入。A组中有1名中国人成功地接受了TRA的介入治疗。在TRA的病例中90%术后当日下床活动。在C组中。平均手术时间与TRA者相似。在B组中有几例住院期间并发症,多数为局部穿刺血管的并发症。两组病人出院后随访2个月均无与穿刺血管相关的并发症。结论:TRA的冠心病诊断和治疗具有较高的成功率,和较低的并发症发生率。下床早,出院早,住院费? | 孙玲 Limbruno Ugo | 2003 | 中国医药导刊2003，5，3： | 2 |
| 18 | Preoperative chemotherapy in gastric cancer: expanding the indications, limiting the overuse显示文摘 | Ferdinando C. M. Cananzi Alberto Biondi Luca Cozzaglio Domenico D’Ugo Roberto Persiani Vittorio Quagliuolo | 2015 | Gastric Cancer2015，，1： | 2 |
| 19 | Response to neoadjuvant chemotherapy and effects of tumor regression in gastric cancer显示文摘 | D. D’Ugo R. Persiani S. Rausei A. Biondi V. Vigorita S. Boccia R. Ricci | 2006 | European Journal of Surgical Oncology2006，，10： | 2 |
| 20 | Preoperative treatment and surgery in gastric cancer: friends or foes?显示文摘 | Domenico D’Ugo Stefano Rausei Alberto Biondi Roberto Persiani | 2009 | Lancet Oncology2009，，2： | 2 |
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