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| 1 | An eighteen-month follow-up study on the effects of Intravitreal Dexamethasone Implant in diabetic macular edema refractory to anti-VEGF therapy显示文摘AIM: To evaluate the long-term efficacy and safety of dexamethasone implants in subjects affected by diabetic macular edema(DME) resistant to anti-vascular endothelial growth factor(VEGF) therapy.METHODS: Thirty-two DME patients were enrolled.A700 microgram slow release Intravitreal Dexamethasone Implant(Ozurdex~) was placed in the vitreous cavity.All patients were followed for 18 mo.Best-corrected visual acuity(BCVA) measured with Early Treatment Diabetic Retinopathy Study(ETDRS) and central macular thickness(CMT) exams were carried out at baseline(T0)and after 1(T1),3(T3),4(T4),6(T6),9(T9),12(T12),15(T15),and 18mo(T18) post injection. RESULTS: Repeated measures ANOVA showed an effect of treatment on ETDRS(P<0.0001).Post hoc analyses revealed that ETDRS values were significantly increased at T1,T3,T4,T9,and T15(P <0.001) as compared to baseline value(T0).At T6,T12,and T18,ETDRS values were still statistically higher than baseline(P<0.001 vs T0).However,at these time points,we observed a trend to return to baseline conditions.ANOVA also showed an effect of treatment(P <0.0001).CMT decreased significantly at T1,T3,T4,T9,and T15(P<0.001).At T6(P<0.01),T12 and T18(P<0.001) CMT was also significantly lower than T0 although a trend to return to the baseline conditions was also observed.CONCLUSION: Our findings demonstrate that Intravitreal Dexamethasone Implant is a good option to improveBCVA and CMT in DME patients resistant to anti-VEGF therapy.Our data also show that the use of drugs administered directly into the vitreous allows achieving appropriate and long-lasting concentration at the site of disease without systemic side effects. | Fernanda Pacella Maria Rosaria Romano Paolo Turchetti Giovanna Tarquini Anna Carnovale Antonella Mollicone Alessandra Mastromatteo Elena Pacella | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 5 |
| 2 | Productivity and Technical Efficiency in the Italian Industry显示文摘 | CUMMINS J D TURCHETTI G WEISS M A | 1996 | Working paper1996，，： | 1 |
| 3 | The socialcost of rheumatoid arthritis in Italy : the results of anestimation exercise 显示文摘 | TURCHETTI G BELLELLI S MOSCA M | 2014 | Reumatismo2014，65，6： | 1 |
| 4 | Numerical Convergence of the Block-Maxima Approach to the Gener- alized Extreme Value Distribution显示文摘 | Davide Faranda Valerio Lucarini Giorgio Turchetti Sandro Vaienti | 2011 | Journal of Statistical Physics2011，，145： | 1 |
| 5 | BRCA1 mutations and clinicopathological features in a sample of Italian women with early-onset breast cancer显示文摘 | Turchetti D Cortesi L Federico M | 2000 | Eur J Cancer2000，36，16： | 1 |
| 6 | A non-phenol-chloroform extraction of double-stranded RNA from plant and fungal tissues显示文摘 | Balijja A Kvarnheden A Turchetti T | 2008 | Virol Methods2008，152，12： | 1 |
| 7 | Cryphonectriaparasitica显示文摘 | Jurc D Turchetti T | 2005 | EPPO Bulletin2005，35，2： | 1 |
| 8 | Lp (a) and lipid disorder in a group of secondary school students selected according to their family anamnesis 显示文摘 | POSTORINO G ALTAVILLA R TURCHETTI V | 1994 | Minerva Med1994，859，10： | 1 |
| 9 | A macromodel for integrated all-mos operationalamplifier显示文摘 | turchetti C Massett G | 1983 | IEEE Journal of solid-state circuits1983，18，4： | 1 |
| 10 | The chemotactic and mitogenic effects of platelet-derived growth factor-BB on rat aorta smooth muscle cells are inhibited by basic fibroblast growth factor显示文摘 | Facchiano A De Marchis F Turchetti E | 2000 | J Cell Sci2000，113，16： | 1 |
| 11 | Psychrophilic yeasts in glacial environments of Alpine glaciers 显示文摘 | TURCHETTI B BUZZINI P GORETTI M | 2008 | FEMS Microbiol Ecoi2008，63，1： | 1 |
| 12 | On the singularities of divergent majorant series arising from normal form theory显示文摘 | D Bessis S Marmi G Turchetti | 1989 | Rendiconti di Matematica1989，9，： | 1 |
| 13 | Parametric yield optimization of MOS VLSI circuits based on simulated annealing and its parallel implementation显示文摘 | Orcioni S Turchetti C | 1994 | Circuits Devices and Systems IEE Proceedings1994，141，5： | 1 |
| 14 | A macromodel for integrated all-MOSoperational amplifiers显示文摘 | Turchetti C Masetti G | 1983 | Solid-State Circuit1983，18，4： | 1 |
| 15 | Catalyst development for steam reforming of methane and model biogas at low temperature 显示文摘 | Angeli S D Turchetti L Monteleone G | 2016 | Applied Catalysis B : Environmental2016，181，： | 1 |
| 16 | On the Approximation of Stochastic Processes by Approximate Identity Neural Networks显示文摘 | Claudio Turchetti Massimo Conti | 1998 | IEEE TRANSACTIONS ON NEURAL NETWORKS1998，9，6： | 1 |
| 17 | Haemorheological and endothelial-dependent alterations in heart failure after ACE inhibitor, calcium antagonist and βblocker显示文摘 | Turchetti V Bellini MA Boschi L | 2002 | Clin Hemorheol Microcirc2002，27，： | 1 |
| 18 | Gastric emptying time in cyclic vomiting syndrome in children 显示文摘 | Turchetti A Guglielmi S Fossati C | 2004 | Eur Rev Med Pharmacol Sci2004，8，6： | 1 |
| 19 | Treat-to-target in rheumatoid arthritis:clinical and pharmaco-economic considerations显示文摘 | Turchetti G Smolen JS Kavanaugh A | | 0，，73： | 1 |
| 20 | Catechins and proanthocyanidins: naturally occurring O-heterocycles with antimicrobial activity 显示文摘 | Buzzini P Turchetti B Ieri F | 2007 | Topics in Heterocyclic Chemistry2007，，10： | 1 |
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