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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | The role of macrophages in the protection of mice against leptospirosis: in vitro and in vlvo studies 显示文摘 | Tu V Adler B Faine S | 1982 | Pathology1982，14，4： | 1 |
| 3 | Hydrogen peroxide dose dependent induction of cell death or hypertrophy incardiomyocytes显示文摘 | Chen Q M Tu V C Wu Y | 2000 | Arch Biochem Biophys2000，373，1： | 1 |
| 4 | A brushing method of lnoculation for screening tomatoes seedlings for resistance to Septoria Lycopersici 显示文摘 | Poysa V Tu J C | 1990 | Plant Disease1990，74，： | 1 |
| 5 | Prevalence, Predictors, and Outcomes of Primary Nonadherence after Acute Myocardial Infarction显示文摘 | Jaekevicius C A Li P Tu J V | 2008 | Circulation2008，117，8： | 1 |
| 6 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 7 | Androgen-induced neurite out growth is mediated by neuritin in motomeurones 显示文摘 | Marron TU Guerini V RusminiP | 2005 | J Neurochem2005，92，1： | 1 |
| 8 | Techniques of at- lantoaxial fixation and the resection of C2 nerve root显示文摘 | Wu J C Tu T H Mummaneni P V | 2012 | World Neurosurg2012，78，6： | 1 |
| 9 | Structure-function analyses of a caffeic acid O-methyltransferase from perennial ryegrass reveal the molecular basis for substrate preference显示文摘 | Louie G V Bowman M E Tu Y | | 0，，： | 1 |
| 10 | Outcome of heart failure with preserved ejection fraction in a population-based study显示文摘 | Bhatia R S Tu J V Lee D S | 2006 | N Engl J Med2006，355，3： | 1 |
| 11 | A multi-wall carbon nanotube tower electrochemical actuator 显示文摘 | Yun Y Shanov V Tu Y | 2006 | Nano Letters2006，6，4： | 1 |
| 12 | Effect of pressure on the luminescence properties of Nd^(3+) doped SrWO4 laser crystal显示文摘 | Errandonea D Tu Chaoyang Jia Guohua Martin I R Rodrlguez-Mendoza U R Lahoz F Tortes M E Lavin V | 2008 | Journal of Alloys and Compounds2008，451，： | 1 |
| 13 | Development of HS-RT-LAMP (loop-mediated isothermal amplification) system for rapid diagnosis of H5 avian influenza virus infection 显示文摘 | Imai M Ninomiya A Minekawa H Notomi T Ishizaki T Tu P V Tien N T K Tashiro M and Odagiri T | 2006 | Journal of Virological Methods2006，24，44： | 1 |
| 14 | Using quality of life to predict hospitalization and mortality in patients with obstructive lung diseases显示文摘 | Fan V S Curtis J R Tu S P | 2002 | Chest2002，122，2： | 1 |
| 15 | The interaction of protein--modified nanodiamond with bacterial cells显示文摘 | Perevedentseva E V Tu J S Cheng C Y | 2006 | Nanotechnology2006，，2： | 1 |
| 16 | Sequence of dielectric anomalies and high temperature relaxation behavior of Na1/2Bi1/2TiO3显示文摘 | Tu C S Sniy I G Schmid V H | 1994 | Physics Review B1994，49，11： | 1 |
| 17 | Cervical cancer screening among Chinese Americans显示文摘 | Taylor V M Jackson J C Tu S P | 2002 | Cancer Detect Prev2002，26，2： | 1 |
| 18 | Characteristics of a Heat Exchanger Based on a Collector Heat Pipe显示文摘 | KONEV S V WANG J L TU C J | 1995 | Heat Recovery Systems & CHP1995，15，5： | 1 |
| 19 | Wall Pressure and Shear Stress Measurements Beneath an Impinging Jet显示文摘 | TU C V WOOD D H | 1996 | Experimental Thermal and Fluid Science1996，13，4： | 1 |
| 20 | CorrosiveSulpur in Mineral Oils: Its Detection and Correlated Transfor-maer Failures显示文摘 | TU MIATTI V MAINA R SCATIGGIO F | 2006 | IEEE International Symposium on ElectricalInsulation2006，，7： | 1 |
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