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| 1 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 2 | Contact lens overrefraction variability in corneal power estimation after refractive surgery显示文摘 | Joslin CE Koster J Tu EY | | 0，，： | 1 |
| 3 | Huntingtin and Huntingtin-assoeiated protein 1 influence neuronal calcium signaling mediated by inoxitol- ( 1,4,5 ) triphosphate receptor type 显示文摘 | Tang TS Tu H Chan EY | 2003 | Neuron2003，39，2： | 1 |
| 4 | Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-( 1, 4,5) triphosphate receptor type 1显示文摘 | Tang TS Tu H Chart EY | 2003 | Neuron2003，39，2： | 1 |
| 5 | Huntingtin and huntingtin-associated protein 1influence neuronal calcium signaling mediatedby inositol-(1,4,5)triphosphate receptor type 1显示文摘 | TANG T-s TU H Chan EY | 2003 | Neuron2003，39，2： | 1 |
| 6 | Successful treat- ment of resistant ocular fusariosis with posaconazole ( SCH-56592 ) 显示文摘 | Tu EY McCartney DL Bcatty RF | 2007 | Am J Ophthalmol2007，143，2： | 1 |
| 7 | Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1显示文摘 | Tang TS Tu H Chan EY | 2003 | Neuron2003，39，2： | 1 |
| 8 | Corneal first surface optical aberrations and visual performance显示文摘 | Applegate RA Hilmantel G Howland HC Tu EY Starck T Zayac EJ | | 0，，05： | 1 |
| 9 | Efficacy of contact lens systems against recent clinical and tap water Acanthamoeba isolates显示文摘 | Shoff ME Joslin CE Tu EY | 2008 | Cornea2008，27，： | 1 |
| 10 | Corneal first surface optical aberrations and visual performance显示文摘 | Applegate RA Hilmantel G Howland H Tu EY Starck T Zayac EJ | 2000 | J Refract Surg2000，15，5： | 1 |
| 11 | Epidemiological characteristics of a Chicago-area Acan-thamoeba keratitis outbreak 显示文摘 | Joslin CE Tu EY McMahon TT Passaro DJ Stayner LT SugarJ | 2006 | Am J Ophthalmol2006，142，2： | 1 |
| 12 | Prognostic factors affecting visual outcome in Acanthamoeba keratitis显示文摘 | Tu EY Joslin CE Sugar J | 2008 | Ophthalmolgy2008，115，： | 1 |
| 13 | The relative value of confocal microscopy and superficial corneal scrapings in the diagncsis of Acanthamoeba keratitis显示文摘 | Tu EY Joslin CE Sugar J | 2008 | Cornea2008，27，： | 1 |
| 14 | Successful treatment of chronic stromal Acanthamoeba keratitis with oral voriconazole monotherapy 显示文摘 | Tu EY Joslin CE Shoff ME | 2010 | Cornea2010，29，： | 1 |
| 15 | The association of contact lens solution use and Acan-thamoeba keratitis 显示文摘 | Joslin CE Tu EY Shoff ME Booton GC Fuerst PA McMahonTT | 2007 | Am J Ophthalmol2007，144，2： | 1 |
| 16 | Successful treat ment of resistant ocular fusariosis with posaconazole (SCH 56592) 显示文摘 | Tu EY McCartney DL Beatty RF | 2007 | AmJ Ophthalmol2007，143，2： | 1 |
| 17 | Contact lens over refraction variability in corneal power estimation after refractive surgery显示文摘 | Joslin CE Kester J Tu EY | 2005 | J Cataract Refract Surg2005，31，12： | 1 |
| 18 | The relative value of confocal microscopy and superficial corneal scrapiugs in the diagnosis of Acanthamoeba keratitis显示文摘 | Tu EY Joslin CE Sugar J | 2008 | Cornea2008，27，7： | 1 |
| 19 | Recalcitrant Beauveria bassiana keratitis:confocal microscopy findings and treatment with posaconazole(Noxafil)显示文摘 | Tu EY Park AJ | 2007 | Cornea2007，26，8： | 1 |
| 20 | Intrastromal antifungal injection with secondary lamellar interface infusion for late-onset infectious keratitis after DSAEK显示文摘 | Tu EY Hou J | 2014 | Cornea2014，33，9： | 1 |
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