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| 1 | Thymosin alpha 1:A comprehensive review of the literature显示文摘Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying,enhancing,and restoring immune function.Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies,as an enhancer of vaccine response,and as a means of curbing morbidity and mortality in sepsis and numerous infections.Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells.In this review,we discuss key literature on the background knowledge and current clinical uses of thymosin alpha 1.Considering the known biochemical properties including antibacterial and antiviral properties,timehonored applications,and the new promising findings regarding the use of thymosin,we believe that thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2. | Asimina Dominari Donald Hathaway III Krunal Pandav Wanessa Matos Sharmi Biswas Gowry Reddy Sindhu Thevuthasan Muhammad Adnan Khan Anoopa Mathew Sarabjot Singh Makkar Madiha Zaidi Michael Maher Mourad Fahem Renato Beas Valeria Castaneda Trissa Paul John Halpern Diana Baralt | 2020 | World Journal of Virology2020，9，5： | 11 |
| 2 | 查看详情显示文摘 | Suman S Trissa J Halligudi S.B | | 0，，： | 1 |
| 3 | Br?nsted acidic ionic liquid:A green,efficientand reusable catalyst system and reaction medium for Fischer esterification显示文摘 | Trissa J Suman S Halligudi S B | 2005 | J Mol Catal2005，234，： | 1 |
| 4 | 显示文摘 | Sajanikumari C S | 1999 | Indian J Chem Sect A:Inorg Bio - inorg Phys Theor Anal Chem1999，8，： | 1 |
| 5 | Oxyfunctionalization of limonene using vanadium complex anchored on functionalized SBA-15 显示文摘 | Trissa J Halligudi SB | 2005 | Journal of Molecular Catalysis A:Chemical2005，229，： | 1 |
| 6 | Zeolite encapsulated ruthenium and cobalt schiff base complexes catalyzed alllic oxidation of α-pinene 显示文摘 | Trissa J Pawant S D Gopinath H | 2002 | J Mol Catal A Chemicals2002，154，： | 1 |
| 7 | Bronsted acidic ionic iiquids~ A green efficient and reusable catalyst system and reaction medium for Fisher esterification 显示文摘 | Trissa J Suman S Halligudi S | 2005 | Mol Catal A:Chem2005，，234： | 1 |
| 8 | Brnsted acidic ionic liquid: a green, effieientand reusable catalyst system and reaction medium for Fischer esterification显示文摘 | Trissa J Suman S Halligudi SB | 2005 | J Mol Catal2005，234，5： | 1 |
| 9 | BrΦnsted acidic ionic liquid: A green, emcientand reusable catalyst system and reaction medium for Fischer esterification显示文摘 | Trissa J Suman S Halligudi S B | 2005 | J Mol Catal2005，234，： | 1 |
| 10 | Bronsted acidic ionic liquids:A green,efficient and reusable catalyst system and reaction medium for Fischer esterification显示文摘 | Trissa J Suman S Halligudi S B | 2005 | Journal of Molecular Catalysis A:Chemical2005，234，12： | 1 |
| 11 | The Human Microbiome and Surgical Disease显示文摘 | Michael J. Morowitz Trissa Babrowski Erica M. Carlisle Andrea Olivas Kathleen S. Romanowski John B. Seal Donald C. Liu John C. Alverdy | 2011 | Annals of Surgery2011，，6： | 1 |
| 12 | Bronsted acidic Sonic liquids: A green, efficient and reusable catalyst system and reaction medium for Fischer esterification显示文摘 | Trissa J Suman S Halligudi S | 2005 | J Mol Catal A : Chemical2005，234，： | 1 |
| 13 | Brtnsted acidic ionic liquid: a green, efficientand reusable catalyst system and reaction medium for Fischer esterification显示文摘 | Trissa J Suman S Halligudi SB | 2005 | J Mol Catal2005，234，5： | 1 |
| 14 | Br0nsted acidic ionic liquid:A green,efficientand reusable catalyst system and reaction medium for Fischer esterification显示文摘 | Trissa J Suman S Halligudi SB | 2005 | J Mol Catal2005，234，： | 1 |
| 15 | Mannich reaction in Brφnsted acidic ionic liquid: A facile synthesis of β - amino carbonyl compounds 显示文摘 | Suman Sahoo Trissa Joseph Trissa Joseph | 2006 | Journal of Molecular Catalysis A : Chemical2006，244，： | 1 |
| 16 | Bottom-up analysis of emergent properties of N-acetylcysteine as an adjuvant therapy for COVID-19显示文摘N-acetylcysteine(NAC)is an abundantly available antioxidant with a wide range of antidotal properties currently best studied for its use in treating acetaminophen overdose.It has a robustly established safety profile with easily tolerated side effects and presents the Food and Drug Administration's approval for use in treating acetaminophen overdose patients.It has been proven efficacious in offlabel uses,such as in respiratory diseases,heart disease,cancer,human immunodeficiency virus infection,and seasonal influenza.Clinical trials have recently shown that NAC's capacity to replenish glutathione stores may significantly improve coronavirus disease 2019(COVID-19)outcomes,especially in high risk individuals.Interestingly,individuals with glucose 6-phosphate dehydrogenase deficiency have been shown to experience even greater benefit.The same study has concluded that NAC's ability to mitigate the impact of the cytokine storm and prevent elevation of liver enzymes,C-reactive protein,and ferritin is associated with higher success rates weaning from the ventilator and return to normal function in COVID-19 patients.Considering the background knowledge of biochemistry,current uses of NAC in clinical practice,and newly acquired evidence on its potential efficacy against COVID-19,it is worthwhile to investigate further whether this agent can be used as a treatment or adjuvant for COVID-19. | Asimina Dominari Donald Hathaway III Abdulhusein Kapasi Trissa Paul Sarabjot Singh Makkar ValeriaCastaneda Sirisha Gara Bishnu Mohan Singh Kuchalambal Agadi Maliha Butt Varadha Retnakumar Spandana Chittajallu Rahima Taugir Muhammad Khawar Sana Manish KC Sarah Razzack Niala Moallem Alina Alvarez Michael Talalaev | 2021 | World Journal of Virology2021，10，2： | 0 |
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