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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 3 | Expression of surfactant associ-ated protein-A and Clara cell 10 kilodahon mRNA in neoplastic and non-neoplastichuman lung tissue as detected by in situ hybridization 显示文摘 | Broers J L Jensen S M Travis W D | 1992 | Lab Invest1992，66，3： | 1 |
| 4 | An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias显示文摘 | Travis W D Costabel U Hansell D M | 2013 | Am J Respir Crit Care Med2013，188，6： | 1 |
| 5 | Cushing syndrome due to primary pigmented nodular adrenocortical disease:findings at CT and MR imaging显示文摘 | Doppman J L Travis W D Nieman L | 1989 | Radiology1989，172，2： | 1 |
| 6 | Lung cancer 显示文摘 | Travis W D Travis L B Devesa S S | 1995 | Cancer1995，75，1： | 1 |
| 7 | Pathology of lung cancer 显示文摘 | Travis W D | 2002 | Clin Chest Med2002，23，1： | 1 |
| 8 | The new world health organization classification of lung tumours 显示文摘 | Brambilla E Travis W D Colby T V | 2001 | Europ Respirat J2001，18，6： | 1 |
| 9 | The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification显示文摘 | TRAVIS W D BRAMBILLA E NICHOLSON A G | 2015 | J Thorae Oneol2015，10，9： | 1 |
| 10 | Numerical analysis of hydrogen risk mitigation measures lbr support of ITER licensing 显示文摘 | Xiao J Travis J R Breitung W | 2010 | Fusion Engineering and Design2010，85，2： | 1 |
| 11 | The influ ence of latex type and concentration显示文摘 | Douglas W Bousfield Travis P Glatter | 2000 | Progress in Organic Coatings2000，38，： | 1 |
| 12 | Lung cancer 显示文摘 | Travis W D Travis L B Devesa S S | 1995 | Cancer1995，75，1： | 1 |
| 13 | Differential effect of amino acid on nitrate uptake and reduction systems in barley roots显示文摘 | Aslam M Travis R L Rains D W | 2001 | Plant Science2001，160，： | 1 |
| 14 | Modeling Spe-cies′ Range Shifts in a Changing Climate:the Impacts of Biotic In-teractions,Dispersal Distance and the Rate of Climate Change显示文摘 | BROOKER R W TRAVIS J M J CLARK E J | 2007 | Journal of Theoretical Biology2007，245，1： | 1 |
| 15 | Ranchland ownership change in the Greater Yellowstone ecosystem,1990-2001:implications for conservation显示文摘 | Gosnell H Haggerty J Travis W | | 0，，： | 1 |
| 16 | New pathologic classification of lung cancer: relevance for clinical practice and clinical trials 显示文摘 | Travis W D Brambilla E Riely G J | 2013 | J Clin Oncol2013，31，8： | 1 |
| 17 | Surgical pathology of the lung Wegener's granulomatosis: review of 87 open lung biopsies from 67 patients显示文摘 | Travis W D G Hoffman S Leavitt R Y | 1991 | Surg Pathol1991，15，1： | 1 |
| 18 | Rootstock effects on gene expression patterns in apple tree scions显示文摘 | JENSEN P J RYTTER J DETWILER E A TRAVIS J W MCNELLIS T W | 2003 | Plant Molecular Biology2003，53，4： | 1 |
| 19 | SciAutonics-Auburn engi- neering's low-cost high-speed ATV for the 2005 DARPA grand challenge显示文摘 | Travis W Daily R Bevly D M | 2006 | Journal of Field Robotics2006，23，8： | 1 |
| 20 | Nitric oxide synthase cyclooxygenase-2,and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma显示文摘 | Marrogi A J Travis W D Welsh J A | 2000 | Clin Cancer Res2000，6，12： | 1 |
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