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| 1 | Inhalation of nanoparticle-based drug for lung cancer treatment:Advantages and challenges显示文摘Ever since the success of developing inhalable insulin,drug delivery via pulmonary administration has become an attractive route to treat chronic diseases.Pulmonary delivery system for nanotechnology is a relatively new concept especially when applicable to lung cancer therapy.Nano-based systems such as liposome,polymeric nanoparticles or micelles are strategically designed to enhance the therapeutic index of anti-cancer drugs through improvement of their bioavailability,stability and residency at targeted lung regions.Along with these benefits,nano-based systems also provide additional diagnostic advantages during lung cancer treatment,including imaging,screening and drug tracking.Nevertheless,delivery of nanobased drugs via pulmonary administration for lung cancer therapy is still in its infancy and numerous challenges are expected.Pharmacology,immunology,toxicology and largescale manufacturing(stability and activity of drugs)are some aspects in nanotechnology that should be taken into consideration for the development of inhalable nano-based chemotherapeutic drugs.This review will focus on the current inhalable nano-based drugs for lung cancer treatment. | Wing-Hin Lee Ching-Yee Loo Daniela Traini Paul M.Young | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，6： | 6 |
| 2 | Muscle RING-finger protein-1 (MuRFl) functions and cellular localization are regulated by SUMOl post-translational modification显示文摘The muscle RING-finger protein-1 (MuRFl) is an E3 ubiquitin ligase expressed in skeletal and cardiac muscle tissues and it plays important roles in muscle remodeling. Upregulation of MuRFl gene transcription participates in skeletal muscle atrophy, on contrary downregulation of protein expression leads to cardiac hypertrophy. MuRFl gene point mutations have been found to generate protein aggregate myopathies defined as muscle disorder characterized by protein accumulation in muscle fibers. We have discovered that MuRFl turned out to be also a target for a new post-translational modification arbitrated by conjugation of SUM01 and it is mediated by the SUMO ligases E2 UBC9 and the E3 PIASy/4. SUMOylation takes place at lysine 238 localized at the second coiled-coil protein domain that is required for efficient substrate interaction for polyubiquitination. We provided evidence that SUMOylation is essential for MuRFl nuclear translocation and its mitochondria accumulation is enhanced in hyper? glycemic conditions delivering a stabilization of the overall SUMOylated proteins in cultured myocytes. Thus, our findings add this SUM01 post-translational modification as a new concept to understand muscle disorders related to the defect in MuRFl activity. | Gabriel Heras Arvind Venkat Namuduri Leonardo Traini Ganna Shevchenko Alexander Falk Sara Bergstrom Lind Mi Jia Geng Tian Stefano Gastaldello | 2019 | Journal of Molecular Cell Biology2019，11，5： | 4 |
| 3 | Direct laser metal sintering as a new approach to fabrication of an isoelastic functionally graded material for manufacture of porous titanium dental implants显示文摘 | T. Traini C. Mangano R.L. Sammons F. Mangano A. Macchi A. Piattelli | 2008 | Dental Materials2008，，11： | 2 |
| 4 | A novel apparatus for the determination of solubility in pressurized metered dose inhalers显示文摘 | Traini D Young PM Price R | | 0，，10： | 1 |
| 5 | Single--dose, randomized,crossover bioequivalence study of amlodipine maleate versus amlodipine besylate in healthy volunteers 显示文摘 | Mignini F Tomassoni D Traini E | 2007 | Clin Exp Hypertens2007，29，8： | 1 |
| 6 | The influence of dose on the performance of dry powder inhalation system显示文摘 | YOUNG P M EDGE S TRAINI D | 2005 | Inter J Pharm2005，2005，： | 1 |
| 7 | Comparative study of erythritol and lactose monohydrate as carriers for inhala- tion: atomic force microscopy and in vitro correlation 显示文摘 | Traini D Young P M Jones M Edge S Price R | 2006 | Eur J Pharm Sci2006，27，： | 1 |
| 8 | Multiple dosing of simvastatin inhibits airway mucus production of epithelial ceils : implications in the treatment of chronic obstructive airway pathologies 显示文摘 | Marin L Traini D Bebawy M | 2013 | Eur J Pharrn Biopharm2013，84，3： | 1 |
| 9 | Lipid droplets and adipose metabo-lism: a novel role for FSP27/CIDEC 显示文摘 | Traini M Jessup W | 2009 | Curr Opin Lipi- dol2009，20，： | 1 |
| 10 | Morphological and cytofluorimetric analysis of adult mesenchymal stem cells expanded exvivo from periodontal ligament显示文摘 | Trubiani O Di Primio R Traini T | 2005 | Int J Immunopathol Pharmacol2005，18，2： | 1 |
| 11 | Influence of interimplant distance on bone microstrueture: a histomorphometric study in dogs显示文摘 | Traini T Novaes AB Jr Papalexious V | 2008 | Clin Implant Dent Relat Res2008，10，1： | 1 |
| 12 | Direct Laser Metal Sintering as a New Approach to Fabrication of an Isoelastic Functionally Graded Material for Manufacture of Porous Titanium Dental Implants显示文摘 | Traini T Manganob C Sammons R L | 2008 | Dental Materials2008，24，： | 1 |
| 13 | In vitro, and ex vivo, methods predict the enhanced lung residence time of liposomal ciprofloxacin formulations for nebulisation 显示文摘 | Hui XO Benaouda F Traini D | 2014 | Eur J Pharm Biopharm2014，86，1： | 1 |
| 14 | A histologic and histomorphometric evaluation of anorganic bovine bone retrieved 9 years after a sinus augmentation procedure显示文摘 | Traini T Valentini P Iezzi G | 2007 | J Periodontol2007，78，5： | 1 |
| 15 | Micro-particle corrugation, adhesion and inhalation aerosol efficiency显示文摘 | Santoso Adi Handoko Adi Patricia Tang Daniela Traini Hak-kim Chan Paul M. Young | 2008 | European Journal of Pharmaceutical Sciences2008，，1： | 1 |
| 16 | Morphologlca and cytolurimetric analysis of adult mesenchymal stem cells expand ex vivo from periodontal ligament显示文摘 | Trabiani O Di Primio R Traini T | 2005 | Int J Immunpathol Pharmaeol2005，18，2： | 1 |
| 17 | Direct laser metal sintering as a new approach to fabrication of an isoelastic functionally graded material for manufacture of porous titanium dental implants 显示文摘 | Traini T Mangano C Sammons RL | 2008 | Dent Mater2008，24，11： | 1 |
| 18 | Nicardipine:a hy-potensive dihydropyridine-type calcium antagonist with apeculiar cerebrovascular profile 显示文摘 | Amenta F Tomassoni D Traini E | 2008 | Clin Exp Hypertens2008，30，8： | 1 |
| 19 | Single-dose, randomized, crossover, bioequivalence study of amlodipine maleate versus am- lodipine besylate in healthy volunteers显示文摘 | Mignini F Tomassoni D Traini E | 2007 | Clin Exp Hypertens2007，29，8： | 1 |
| 20 | Morphological and cytofluorimetric analysis of adult mesenchyamal stem cells expanded ex vivo from periodontal ligament显示文摘 | Trubiani O Di primio R Traini T | 2005 | Int J Immunopathol Pharmacol2005，18，2： | 1 |
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