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| 1 | Regulation of NKG2D ligand gene expression 显示文摘 | EAGLE RA TRAHERNE JA ASHIRU O | 2006 | Hum Immunol2006，67，3： | 1 |
| 2 | Singlenucleotide polymorphism and linkagedisequilibrium within the TCR alpha / deltalocus 显示文摘 | Moffatt MF Traherne JA Abecasis GR et a 1 | 2009 | Hum Mo 1 Genet2009，9，： | 1 |
| 3 | ULBP6/RAET1L is an additional human NKG2D ligand 显示文摘 | Eagle RA Traherne JA Hair JR Jafferji I Trowsdale J | 2009 | Eur J Immunol2009，39，12： | 1 |
| 4 | ULBP6/RAET1L is an additional human NKG2D ligand显示文摘 | Eagle RA Traherne JA Hair JR | 2009 | Eur J Immunol2009，39，11： | 1 |
| 5 | Cutting edge:expansion of the KIR locus by unequal crossing over显示文摘 | Martin MP Bashirova A Traherne J | 2003 | J Immunol2003，171，： | 1 |
| 6 | Regulation of NKG2D ligand gene expression 显示文摘 | Eagle RA Traherne JA Ashiru O Wills MR Trowsdale J | 2006 | Hum Immunol2006，67，3： | 1 |
| 7 | Mechanisms of copy number variation and hybrid gene formation in the KIR immune gene complex 显示文摘 | Traherne J A Martin M Ward R | 2010 | Hum Mol Genet2010，19，： | 1 |
| 8 | Natural-killer cell ligands at the maternal-fetal interface UL-16 binding proteins MHC class-I chain related molecules HLA-F and CD48显示文摘 | Apps R Gardner L Traherne J | | 0，，： | 1 |
| 9 | Natural-killer cell ligands at the maternal-fetal interface: UL-16 binding proteins, MHC class-Ⅰ chain related inoleeulcs, HLA-F and CD48 显示文摘 | Apps R Ganlner L Traherne J | 2008 | Hum Reprod2008，23，11： | 1 |
| 10 | KIR haplotypes are associated with late-onset type I diabetes in European-American families显示文摘 | Traherne JA Jiang W Valdes AM | 2016 | Genes Immun2016，17，1： | 1 |
| 11 | Is the effective Lagrangian for quantum chromodynamics a a model? 显示文摘 | Rosenzweig C Schechter J Trahern C G | 1980 | Phys RevD1980，21，： | 1 |
| 12 | Single nucleotide polymorphism and linkage disequilibrium within the TCR alpha/delta locus显示文摘 | Moffatt MF Traherne JA Abecasis GR | 2009 | Hum Mol Genet2009，9，： | 1 |
| 13 | Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria显示文摘Malaria is one of the deadliest infectious diseases in the world. Immune responses to Plasmodium falciparum malaria vary among individuals and between populations. Human genetic variation in immune system genes is likely to play a role in this heterogeneity. Natural killer (NK) cells produce inflammatory cytokines in response to malaria infection, kill intraerythrocytic Plasmodium falciparum parasites by cytolysis, and participate in the initiation and development of adaptive immune responses to plasmodial infection. These functions are modulated by interactions between killer-cell immunoglobulin-like receptors (KIRs) and human leukocyte antigens (HLAs). Therefore, variations in KIR and HLA genes can have a direct impact on NK cell functions. Understanding the role of KIRs and HLAs in immunity to malaria can help to better characterize antimalarial immune responses. In this review, we summarize the different KIRs and HLAs associated with immunity to malaria thus far. | Stephen Tukwasibwe Annettee Nakimuli James Traherne Olympe Chazara Jyothi Jayaraman John Trowsdale Ashley Moffett Prasanna Jagannathan Philip JRosenthal Stephen Cose Francesco Colucci | 2020 | Cellular & Molecular Immunology2020，17，8： | 0 |
| 14 | HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation显示文摘AIM:To investigate influence of human leukocyte antigen(HLA)and killer immunoglobuline-like receptor(KIR)genotypes on risks of acute rejection(AR)after liver transplantation(LTX).METHODS:In this retrospective study we included143 adult donor-recipient pairs with a minimum of 6mo follow-up after LTX for whom DNA was available from both donor and recipients.Clinical data,all early complications including episodes and severity of AR and graft/patient survival were registered.The diagnosis of AR was based on clinical,biochemical and histological criteria.All suspected episodes of AR were biopsy confirmed.Key classical HLA loci(HLA-A,HLA-B,HLA-C and HLA-DRB1)were genotyped using Sanger sequencing.16 KIR genes were genotyped using a novel real time PCR approach which allows for determination of the diploid copy number of each KIR gene.Immunohistochemical staining for T(CD3),B(CD20)and natural killer(NK)cells(CD56 and CD57)were performed on liver biopsies from 3 different patient groups[primary sclerosing cholangitis(PSC),primary biliary cirrhosis and non-autoimmune liver disease],10 in each group,with similar grade of AR.RESULTS:Fourty-four(31%)patients were transplanted on the basis of PSC,40%of them had AR vs 24%in the non-PSC group(P=0.04).No significant impact of donor-recipient matching for HLA and KIR genotypes was detected.In the overall recipient population an increased risk of AR was detected for HLA-B*08(P=0.002,OR=2.5;95%CI:1.4-4.6),HLA-C*07(P=0.001,OR=2.4;95%CI:1.4-4.0)and HLA-DRB1*03(P=0.03,OR=1.9;95%CI:1.0-3.3)and a decreased risk for HLA-DRB1*04(P=0.001,OR=0.2;95%CI:0.1-0.5).For HLA-B*08,HLA-C*07 and DRB1*04 the associations remained evident in a subgroup analysis of non-PSC recipients(P=0.04,P=0.003 and P=0.02,respectively).In PSC recipients corresponding P values were 0.002,0.17 and 0.01 for HLA-B*08,HLA-C*07and DRB1*04,respectively.A dosage effect of AR prevalence according to the PSC associated HLA alleles was also notable in the total recipient population.For HLA-B*08 the frequency of AR was 56%in HLA-B*08homozygous recipients,39%in heterozygous recipients and 21%in recipients lacking HLA-B*08(P=0.02).The same was observed for the HLA-C*07 allele with AR in 57%,27%and 18%in recipients being homozygous,heterozygous and lacking HLA-C*07 respectively(P=0.003).Immunohistochemical analysis showed similar infiltration of T,B and NK cells in biopsies with AR in all three groups.CONCLUSION:We found significant associations between the PSC-associated HLA-B*08,HLA-C*07,HLADRB1*03 and HLA-DRB1*04 alleles and risk of AR in liver transplant recipients. | Bjarte Fosby Sigrid Nss Johannes R Hov James Traherne Kirsten M Boberg John Trowsdale Aksel Foss Pl-Dag Line Andre Franke Espen Melum Helge Scott Tom H Karlsen | 2014 | World Journal of Gastroenterology2014，20，14： | 0 |
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