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| 1 | Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats显示文摘AIM:To investigate the metabolic changes in skeletal muscle and/or adipose tissue in glucagon-like peptide-1-induced improvement of nonalcoholic fatty liver disease(NAFLD).METHODS:Male Wistar rats were fed either a control diet(control group)or a high-fat diet(HFD).After 4wk,the HFD-fed rats were subdivided into two groups;one group was injected with exenatide[HFD-Ex(+)group]and the other with saline[HFD-Ex(-)group]every day for 12 wk.The control group received saline and were fed a control diet.Changes in weight gain,energy intake,and oxygen consumption were analyzed.Glucose tolerance tests were performed after 8 wk of treatment.Histological assessments were performed in liver and adipose tissue.RNA expression levels of lipid metabolism related genes were evaluated in liver,skeletal muscle,and adipose tissue.RESULTS:Exenatide attenuated weight gain[HFDEx(-)vs HFD-Ex(+)]and reduced energy intake,which was accompanied by an increase in oxygen consumption and a decrease in the respiratory exchange ratio[HFD-Ex(-)vs HFD-Ex(+)].However,exenatide did not affect glucose tolerance.Exenatide reduced lipid content in the liver and adipose tissue.Exenatide did not affect the expression of lipid metabolism-related genes in the liver or skeletal muscle.In adipose tissue,exenatide significantly upregulated lipolytic genes,including hormone-sensitive lipase,carnitine palmitoyltransferase-1,long-chain acyl-CoA dehydrogenase,and acyl-CoA oxidase 1[HFD-Ex(-)vs HFD-Ex(+)].Exenatide also upregulated catalase and superoxide dismutase 2[HFD-Ex(-)vs HFD-Ex(+)].CONCLUSION:In addition to reducing appetite,enhanced lipid use by exenatide in adipose tissue may reduce hepatic lipid content in NAFLD,most likely by decreasing lipid influx into the liver. | Kosuke Tanaka Yuko Masaki Masatake Tanaka Masayuki Miyazaki Munechika Enjoji Makoto Nakamuta Masaki Kato Masatoshi Nomura Toyoshi Inoguchi Kazuhiro Kotoh Ryoichi Takayanagi | 2014 | World Journal of Gastroenterology2014，20，10： | 6 |
| 2 | 臂间血压差与脑卒中的关系显示文摘为了检测同时测量的双臂血压差值是否可识别踝臂血压指数〈0.90的受试者,及是否能预测未来心血管事件,Hirofumi等收集来自10个队列的日本受试者13 317人的数据(基于一般人群的队列,既往有心血管事件病史的队列及有心血管病危险因素的队列)进行荟萃分析。 | 刘青 叶鹏 Hirofumi T Toshiaki O Toshiharu N Chisa M Kazuomi K Satoshi H Yoshikuni K Toyoshi I Yasutaka M Katsuhiko K Yasuharu T Motoyuki N Takayoshi O Hirotaka W Masanori M Mitsuru O Norihisa I Michinari N Tetsuo S Charalambos V Akira Y | 2018 | 中华高血压杂志2018，26，6： | 3 |
| 3 | The Effect of Postoperative Analgesia with Continuous Epidural Bupivacaine After Cesarean Section on the Amount of Breast Feeding and Infant Weight Gain显示文摘 | Munetaka Hirose Yumi Hara Toyoshi Hosokawa Yoshifumi Tanaka | 1996 | Anesthesia & Analgesia1996，，6： | 2 |
| 4 | Antieonflict effects of lavender oil and identification of its active constituents显示文摘 | Toyoshi Umezu Kimiyo Nagano Hiroyasu Ito | 2006 | Pharmacol Biochem Behav2006，85，： | 1 |
| 5 | Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic β-cell line, MIN6—a role of NAD(P)H oxidase in β-cells显示文摘 | Hirotaka Tsubouchi Toyoshi Inoguchi Mieko Inuo Maiko Kakimoto Toshiyo Sonta Noriyuki Sonoda Shuji Sasaki Kunihisa Kobayashi Hideki Sumimoto Hajime Nawata | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 6 | Antihypertensive effect of a 'y-aminobutyric acid rich tomato cultivar 'DG03-9'in sponta- neously hypertensive rats显示文摘 | Yoshimura M Toyoshi T Sano A | 2009 | Journal of agricultural and food chem- istry2009，58，1： | 1 |
| 7 | Anti-conflict effects of lavender oil and identification of its active constituent显示文摘 | Toyoshi Umezu Kimiyo Nagano Hiroyasu Ito | 2006 | Pharmacology Biochemistry and Behavior2006，85，： | 1 |
| 8 | Antihypertensive effect of a γ-aminobutyric acid rich tomato cultivar 'DG03-9' in spontaneously hypertensive rats显示文摘 | Yoshimura M Toyoshi T Sano A | 2010 | J Agric Food Chem2010，58，： | 1 |
| 9 | Adenovirus-mediated high expression of resistin causes dyslipidemia in mice显示文摘 | Naoichi S Kunihisa K Toyoshi I | 2005 | Endocrinology2005，146，1： | 1 |
| 10 | The meaning of serum levels of advanced glycosylation end products in diabetic nephropathy显示文摘 | Tomoko S Toyoshi I Fumio U | 2000 | Metabolism2000，49，8： | 1 |
| 11 | Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women显示文摘 | Keizo Ohnaka Suminori Kono Toyoshi Inoguchi Guang Yin Makiko Morita Masahiro Adachi Hisaya Kawate Ryoichi Takayanagi | 2010 | Diabetes Research and Clinical Practice2010，，： | 1 |
| 12 | The meaning of serum levels of advanced glycosy lation end products in diabetic nephropathy显示文摘 | Tomoko S Toyoshi I FumioU | 2000 | Metabonsm2000，49，8： | 1 |
| 13 | Antihypertensive activity of purple corn color in spontaneously hypertensive rats 显示文摘 | TOYOSHI T KOHDA T | 2004 | Foods & Food Ingredients Journal of Japan2004，209，8： | 1 |
| 14 | Evalution of oxidative stress in diabetic animals by in vivo electron spin resonance measurementroleof protein kinase C显示文摘 | Toshiyo S Toyoshi I Hirotaka T | | 0，，： | 1 |
| 15 | Antieonflict effects of lavender oil and identification of its active constituents显示文摘 | Toyoshi U Kimiyo N Hiroyasu I | 2006 | Pharmacology Biochemistry and Behavior2006，85，4： | 1 |
| 16 | Development of Gauge Change Bogies显示文摘 | Noriaki Tokuda Isao Okamoto Toyoshi Fujita | 2003 | QR of RTRI2003，44，3： | 1 |
| 17 | Solid-liquid flows simulation for debris avalanche analysis 显示文摘 | KIKUCHI M WADA Y TOYOSHI T | 2011 | Key Engineering Materials2011，，： | 1 |
| 18 | Calcium oscillation linked to pacemaking of interstitial cells of Cajal: requirement of calcium influx and localization of TRP4 in caveolae显示文摘 | Torihashi Shigeko Fujimoto Toyoshi Trost Claudia | 2002 | J Biol Chem2002，277，19： | 1 |
| 19 | Heat shock protein-antigen presenting cell interactions显示文摘 | Toyoshi M | 2004 | Methods2004，32，1： | 1 |
| 20 | Antihypertensive effect of a gamma - aminobutyric acid rich tomato cuhivar 'DG03 - 9' in spontaneously hypertensive rats 显示文摘 | Yoshimura M Toyoshi T Sano A | 2010 | Journal of Agricultural and Food Chemistry2010，58，1： | 1 |
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