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| 1 | Recurrent miscarriage Are three miscarriages one too many? Analysis of a Scottish populationbased database of 151, 021 pregnancies显示文摘 | Sohinee Bhattacharya John Townend Siladitya Bhattacharya | 2010 | European Journal of Obstetrics & Gynecology and Reproductive Biology2010，15，： | 7 |
| 2 | Current management of gastro-oesophageal reflux disease—treatment costs,safety profile,and effectiveness:a narrative review显示文摘Background The purpose of this study was to review the current management of gastro-oesophageal reflux disease(GORD),including treatment costs,safety profile and effectiveness.Methods A literature review was performed of randomized-controlled trials,systematic reviews,Cochrane reports and National/Societal guidelines of themedical,endoscopic and surgicalmanagement of GORD.Proton pump inhibitor(PPI)prescribing patterns and expenditure were reviewed in different countries,including Australia,Canada,New Zealand,UK and USA.Results Proton pump inhibitors(PPIs)are primarily indicated for control of GORD,Helicobacter pylori eradication(combined with antibiotics),preventing NSAID-induced gastrointestinal bleeding and treating peptic ulcer disease.There is widespread overprescribing of PPIs in Western and Eastern nations in terms of indication and duration,with substantial expense for national health providers.Despite a favourable short-term safety profile,there are observational associations of adverse effects with long-term PPIs.These include nutrient malabsorption,enteric infections and cardiovascular events.The prevalence of PPI use makes their long-termsafety profile clinically relevant.Cost-benefit,symptom control and quality-oflife outcomes favour laparoscopic fundoplication rather than chronic PPI treatment.Laparoscopic fundoplication in long-termmanagement of PPI-responsive GORD is supported by SAGES,NICE and ACG,and PPI-refractory GORD by AGA and SAGES guidelines.The importance of establishing a definitive diagnosis prior to invasive management is emphasized,especially in PPI-refractory heartburn.Conclusions We examined evidence-based guidelines for PPI prescribing and deprescribing in primary care and hospital settings and the need for PPI stewardship and education of health professionals.This narrative review presents the advantages and disadvantages of surgical,endoscopic and medical management of GORD,which may assist in shared decision making and treatment choice in individual patients. | Tahmina Lata Jodie Trautman Philip Townend Robert B.Wilson | 2023 | Gastroenterology Report2023，11，1： | 3 |
| 3 | Seasonal variation of tidal prism and energy in the Changjiang River estuary: a numerical study显示文摘Tidal rivers are intrinsically complex because tidal propagation is influenced by river discharge. This study aims to examine the seasonal variation of tidal prism and energy variance in the tidal river of the Changjiang(Yangtze) River estuary in China. In order to quantify the behaviour of river and tide,we use numerical modelling that has been validated using measured data. We conduct our analysis by quantifying the discharge and energy variance in separate components for both the river and the tide,during wet and dry seasons. We note various definitions of tidal prism and explore the difference between tidal discharge on the flood and ebb and tidal storage volume. The results show that the river discharge attenuates the tidal motion and reduces the tidal flood discharge but the tidal storage volume is approximately constant with different riverine discharge since part of the fresh water discharge is intercepted and captured in the estuary due to the backwater effect. It appears that the tidal discharge adjusts according to the variation of river discharge to keep a constant tidal storage volume. An analysis of the hydraulics shows that the transition from tidal dominance(at the mouth) to river dominance(upstream) depends on the location of tidal current reversal which varies from wet season to dry season. Duringthe wet season,the Changjiang River estuary is totally dominated by energy from fresh water discharge. | 张敏 Ian Howard TOWNEND 蔡华阳 周云轩 | 2016 | Chinese Journal of Oceanology and Limnology2016，34，1： | 2 |
| 4 | An Automatic Intrusion Diagnosis Approach for Clouds显示文摘Virtual machines have attracted significant attention especially within the high performance computing community. However, there remain problems with respect to security in general and intrusion detection and diagnosis in particular which underpin the realization of the potential offered by this emerging technology. In this paper, one such problem has been highlighted, i.e., intrusion severity analysis for large-scale virtual machine based systems, such as clouds. Furthermore, the paper proposes a solution to this problem for the first time for clouds. The proposed solution achieves virtual machine specific intrusion severity analysis while preserving isolation between the security module and the monitored virtual machine. Furthermore, an automated approach is adopted to significantly reduce the overall intrusion response time. The paper includes a detailed description of the solution and an evaluation of our approach with the objective to determine the effectiveness and potential of this approach. The evaluation includes both architectural and experimental evaluation thereby enabling us to strengthen our approach at an architectural level as well. Finally, open problems and challenges that need to be addressed in order to make further improvements to the proposed approach have been highlighted. | Junaid Arshad Paul Townend | 2011 | International Journal of Automation and computing2011，8，3： | 2 |
| 5 | A clinical study of child dental anxiety显示文摘 | Townend E Dimigen G Fang D | 2000 | Behav Res Ther2000，38，1： | 1 |
| 6 | Job satisfaction,stress and burnout in Australian specialist anaesthetists显示文摘 | Kluger MT Townend K Laidlaw T | 2003 | Anaesthesia2003，58，4： | 1 |
| 7 | Relaxations in double base propellants 显示文摘 | Townend D J Warren R C | 1985 | Polymer1985，26，： | 1 |
| 8 | Changes in soil structure and hydraulic properties in regenerating rain forest显示文摘 | Deuchras S A Townend J Aitkenhead M J | 1999 | Soil Use and Management1999，15，： | 1 |
| 9 | Respiratory sinus arrhythmia and central respiratory drive in humans显示文摘 | Al-Ani M Forkins AS Townend JN | 1996 | Clin Sci (London)1996，90，3： | 1 |
| 10 | Homocysteine and atherothrombosis-mechanisms for injury显示文摘 | Thambyrajah J Townend JN | 2000 | Eur Heart J2000，21，： | 1 |
| 11 | Respiratory si- nus arrhythmia and central respiratory drive in humans 显示文摘 | A1-Ani M Forkins AS Townend JN | 1996 | Clin Sci(Lond)1996，90，3： | 1 |
| 12 | Feeling sad and useless:an investigation into personal acceptance of disability and its association withdepression following stroke显示文摘 | Townend E Tinson D Kwan J | 2010 | Clin Rehabil2010，24，6： | 1 |
| 13 | Relaxation in double base propellants 显示文摘 | Townend D J Warren R C | 1985 | Polymer1985，26，1： | 1 |
| 14 | Feeling sad and useless: an investigation into personal acceptance of disability and its association with depression following strok显示文摘 | Townend E Tinson D Kwan J | 2010 | Clin Rehabil2010，24，6： | 1 |
| 15 | Fundus autofluorescence in exudative age-related macular degeneration显示文摘 | McBain VA Townend J Lois N | 2007 | Br J Ophthalmol2007，91，4： | 1 |
| 16 | Mapping QTLs associated with drought avoidance in upland rice grown in the Philippines and West Africa显示文摘 | PRICE A H TOWNEND J JONES M P | 2002 | Plant Molecular Biolo- gy2002，48，5： | 1 |
| 17 | Hibernating myocardium:morphological correlates of inotropic stimulation and glucose uptake显示文摘 | Pagano D Townend JN Parums DV | 2000 | Heart2000，83，4： | 1 |
| 18 | Relaxation in double base propellants显示文摘 | Townend D J Warren R C | 1985 | Polymer1985，26，： | 1 |
| 19 | An empirical analysis of credit default swaps显示文摘 | Frank S. Skinner Timothy G. Townend | 2002 | International Review of Financial Analysis2002，，3： | 1 |
| 20 | The effects of hypothermia on human left ventricular contractile function during cardiac surgery显示文摘 | Lewis ME Al-Khalidi AH Townend JN | 2002 | J Am Coll Cardiol2002，39，1： | 1 |
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