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| 1 | Leptin: a multifunctional hormone显示文摘Leptin is the protein product encoded by the obese (ob)gene. It is a circulating hormone produced primarily by the adipose tissue. ob/ob mice with mutations of the gene encoding leptin become morbidly obese, infertile, hyperphagic, hypothermic,and diabetic. Since the cloning of leptin in 1994, our knowledge in body weight regulation and the role played by leptin has increased substantially. We now know that leptin signals through its receptor, OB-R, which is a member of the cytokine receptor superfamily. Leptin serves as an adiposity signal to inform the brain the adipose tissue mass in a negative feedback loop regulating food intake and energy expenditure. Leptin also plays important roles in angiogenesis, immune function, fertility and bone formation. Humans with mutations in the gene encoding leptin are also morbidly obese and respond to leptin treatment,demonstrating that enhancing or inhibiting leptin’s activities in vivo may have potential therapeutic benefits. | HUANG Lu, CAI LI(Tel: (214)-648-3340 Fax: (214)-648-9191 E-mail: li03@utsw.swmed.edu)(1 Touchstone Center for Diabetes Research1 Departments of Physiology and,2 Departments of Internal MedicineThe University of Texas Southwestern Medical Center5323 H. | 2000 | Cell Research2000，10，2： | 35 |
| 2 | The power of efficiency显示文摘 | Touchstone CA | 2006 | Dent Equip and Mat2006，，： | 1 |
| 3 | Mechanism of Ischemic Mitral Regurgitation: An Experimental Evaluation显示文摘 | Sanjiv Kaul William D. Spotnitz William P. Glasheen Dale A. Touchstone | 1991 | Circulation1991，，： | 1 |
| 4 | Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa:superoxide dismutase as major enzyme protectant against oxygen toxicity显示文摘 | Alvarez J G Touchstone J C Blasco L | 1987 | J Androl1987，8，： | 1 |
| 5 | Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa显示文摘 | Alvarez J G Touchstone J C Blasco L | 1987 | J Androl1987，8，： | 1 |
| 6 | Effects of successful intravenous reperfusion therapy on reginal myocardiad fumction and geometry in humans: Tomographic asessment using two-demensional echocardiography显示文摘 | Beller GA Beller GA | 1989 | J Am Coll Cardiol1989，13，： | 1 |
| 7 | Image and reality:Banking in Los Angeles显示文摘 | Kaplan R B Touchstone E E Hagstrom C L | 1995 | Text1995，15，： | 1 |
| 8 | Improved separation of phospholipids in thin - layer chromatography显示文摘 | TOUCHSTONE J C CHEN J C BEAVER K M | 1980 | Lipids1980，15，1： | 1 |
| 9 | Digital transition:the collaboration between dentists and laboratory technicians on CAD/CAM restorations显示文摘 | Touchstone A Nieting T Ulmer N | 2010 | J Am Dent Assoc2010，1412，： | 1 |
| 10 | Digital transition:The collaboration between dentists and laboratory technicians on CAD/CAM restorations显示文摘 | Touchstone A Nieting T Ulmer N | 2010 | Journal of American Dental Association2010，141，2： | 1 |
| 11 | Digital transition: The collaboration between dentists and laboratory technicians on CAD/CAM restorations显示文摘 | Touchstone A Nieting T Ulmer N | 2010 | J Am Dent Assoc2010，141，2： | 1 |
| 12 | Value of regional wall motion abnormality in the emergency room diagnosis of acute myocardial mfarction-a prospective study using two-dimensional echocardiography显示文摘 | Afrookteh A Touchstone D A | 1991 | Circulation1991，84，： | 1 |
| 13 | A population-based job exposure matrix for power-frequency magnetic fields 显示文摘 | BOWMAN J D TOUCHSTONE J A YOST M G | 2007 | J Occup Environ Hyg2007，4，9： | 1 |
| 14 | Effects of successful intravenous reperfusion therapy on regional myocardial functiion and geometry in humans:Tomographic assessment using two-dimensional echocardiography显示文摘 | Beller GA Nygaaed TW | 1989 | J AM Coll Carkiol1989，13，： | 1 |
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