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| 1 | Vertical hepatitis C virus transmission:Main questions and answers显示文摘Hepatitis C virus(HCV) affects about 3% of the world's population and peaks in subjects aged over 40 years. Its prevalence in pregnant women is low(1%-2%) in most western countries but drastically increases in women in developing countries or with high risk behav-iors for blood-transmitted infections. Here we review clinical, prognostic and therapeutic aspects of HCV in-fection in pregnant women and their offspring infected through vertical transmission. Pregnancy-related im-mune weakness does not seem to affect the course of acute hepatitis C but can affect the progression of chronic hepatitis C. In fact, postpartum immune res-toration can exacerbate hepatic inflammation, thereby worsening the liver disease, particularly in patients with liver cirrhosis. HCV infection increases the risk of gestational diabetes in patients with excessive weight gain, premature rupture of membrane and caesarean delivery. Only 3%-5% of infants born to HCV-positive mothers have been infected by intrauterine or perinatal transmission. Maternal viral load, human immunode-ficiency virus coinfection, prolonged rupture of mem-branes, fetal exposure to maternal infected blood con-sequent to vaginal or perineal lacerations and invasive monitoring of fetus increase the risk of viral transmis-sion. Cesarean delivery and breastfeeding increases the transmission risk in HCV/human immunodeficiency virus coinfected women. The consensus is not to offer antivi-ral therapy to HCV-infected pregnant women because it is based on ribavirin(pregnancy category X) because of its embryocidal and teratogenic effects in animal spe-cies. In vertically infected children, chronic C hepatitis is often associated with minimal or mild liver disease and progression to liver cirrhosis and hepatocarcinoma is lower than in adults. Infected children may be treated after the second year of life, given the adverse effects of current antiviral agents. | Grazia Tosone Alberto Enrico Maraolo Silvia Mascolo Giulia Palmiero Orsola Tambaro Raffaele Orlando | 2014 | World Journal of Hepatology2014，6，8： | 5 |
| 2 | Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women?显示文摘Hepatitis C virus(HCV) affects about 3% of the world'spopulation, with the highest prevalence in individuals under 40. The prevalence in pregnant women varies with geographical distribution(highest in developing countries). Prevalence also increases in sub-populations of women at high risk for blood-transmitted infections. HCV infection in pregnancy represents a non-negligible problem. However, most of the past antiviral regimens cannot be routinely offered to pregnant or breastfeeding women because of their side effects. We briefly reviewed the issue of treatment of HCV infection in pregnant/breastfeeding women focusing on the effects of the new direct-acting antivirals on fertility, pregnancy and lactation in animal studies and on the potential risk for humans based on the pharmacokinetic properties of each drug. Currently, all new therapy regimens are contraindicated in this setting because of lack of sufficient safety information and adequate measures of contraception are still routinely recommended for female patients of childbearing potential. | Anna Maria Spera Tarek Kamal Eldin Grazia Tosone Raffaele Orlando | 2016 | World Journal of Hepatology2016，8，12： | 4 |
| 3 | Tissue factor-activated thromboelastograms in children undergoing cardiac surgery:baseline values and comparisons显示文摘 | Miller BE Guzzetta NA Tosone SR | 2003 | Anesth Analg2003，97，5： | 1 |
| 4 | Overview of extracorporeal liver support systems and clinical results显示文摘 | Mclaughlin BE Tosone CM Custer LM | 1999 | Ann NY Acad Sci1999，875，： | 1 |
| 5 | Pharmacology of lacidipine -A vasoselectivecalcium antagonist显示文摘 | Michcli D Ritti E Toson G | | 0，，4： | 1 |
| 6 | Dual inn beam sputtering va- nadium dioxide microbolometers by surface micromachining显示文摘 | ZINTU D TOSONE G MERCURI A | 2002 | In- frared Phys Technol2002，43，： | 1 |
| 7 | Dual ion beam sputtering vanadium dioxide microbolometers by surface micromachining 显示文摘 | ZINTU D TOSONE G MERCURI A | 2002 | Infrared Physics & Technology2002，5，43： | 1 |
| 8 | Movement of Aldicarb in different soil types显示文摘 | Toson M A Wendell W K Wrag W | 1984 | Bull Environ Contain Toxicol1984，，： | 1 |
| 9 | A case of pegylated interferon alpha-related diabetic ketoacidosis: can this complication be avoided?显示文摘 | G. Tosone G. Borgia I. Gentile R. Cerini M. C. D. Conte R. Orlando M. Piazza | 2007 | Acta Diabetologica2007，，3： | 1 |
| 10 | Overview of extracorporesl liver support systems and clinical results显示文摘 | McLaughlin BE Tosone CM Custer LM | | 0，，： | 1 |
| 11 | Overview of ex- tracorporeal liver support systems and clinical results显示文摘 | McLaughlin BE Tosone CM Custer LM | 1999 | Ann NY Acad Sci1999，8，75： | 1 |
| 12 | Fibrinogen in children undergoing cardiac surgery:is it effective?显示文摘 | Miller BE Tosone SR Guzzetta NA | 2004 | Anesth Analg2004，99，5： | 1 |
| 13 | Farmer' s lung precipitins in doubs (a department of France) : prevalence and diagnostic value显示文摘 | Dalphin JC Toson B Monet E et' al | 1994 | Allergy1994，49，： | 1 |
| 14 | Renal ultrastruc- rural findings in Anderson-Fabry disease显示文摘 | Sessa A Toson A Nebuloni M | 2002 | J Nephrol2002，15，2： | 1 |
| 15 | Gemcitabine-based in- duction chemotherapy and concurrent with radiation in advanced head and neck cancer显示文摘 | E1 Deen DA Toson EA E1 Morsy SM | 2012 | Mad Oncol2012，29，5： | 1 |
| 16 | A case of pegylated interferon alpha-related diabetic ketoacidosis: can this complication be avoided?显示文摘 | G. Tosone G. Borgia I. Gentile R. Cerini M. C. D. Conte R. Orlando M. Piazza | 2007 | Acta Diabetologica2007，，3： | 1 |
| 17 | Overview of extracorporeal liver support systems and clinical results显示文摘 | Tosone CM Custer LM | 1999 | Ann N Y Acad Sci1999，875，： | 1 |
| 18 | A reassessment of diag-nostic criteria and treatment of idiopathic urticarial vasculitis: a ret-rospective study of 47 patients 显示文摘 | TosoniC Lodi-Rizzini F Cinquini M | 2009 | Clin Exp Dermatol2009，34，2： | 1 |
| 19 | Pharmacology of lacidipine-A vasoselective calcium antagonist显示文摘 | Emiliangelo R Toson G | 1991 | Cardiovascular Pharmacol1991，17，4： | 1 |
| 20 | Rapid evaluation of coagulopathies after caudiopulmonary bypass in children using modified thrombolastogrphy 显示文摘 | ller BE Guzzetta NA Tosone SR | 2000 | Anesth - Analg2000，90，6： | 1 |
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