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| 1 | Cytokine production in patients with cirrhosis and TLR4 polymorphisms显示文摘AIM:To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.METHODS:The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms,and 10 wild-type patients matched for age,sex and degree of liver failure.TLR4 polymorphisms were determined by sequence-based genotyping.Cytokine production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide(LPS)and lipoteichoic acid(LTA)stimulation.RESULTS:Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients(78%vs 20%,P=0.02).Spontaneous production of interleukin(IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients[IL-6:888.7(172.0-2119.3)pg/m L vs 5540.4(1159.2-26053.9)pg/m L,P<0.001;IL-10:28.7(6.5-177.1)pg/m L vs 117.8(6.5-318.1)pg/m L,P=0.02].However,the production of tumor necrosis factor-α,IL-6 and IL-10 after LPS and LTA stimulation was similar in the two groups.CONCLUSION:TLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients,suggesting that they play a role in the development of cirrhosis complications. | Juan Camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente Maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 2 | Income, inequality, and pollution: a reassessment of the environmental Kuznets Curve显示文摘 | Mariano Torras James K Boyce | 1998 | Ecological Economics1998，，2： | 4 |
| 3 | Effect of heavy metals and water content on the strength of magnesium phosphate cements显示文摘 | Irene Buj Josep Torras Daniel Casellas Miquel Rovira Joan de Pablo | 2009 | Journal of Hazardous Materials2009，，1： | 2 |
| 4 | Abdominal sonographic study of autosomal dominant polycystic kidney disease显示文摘 | Nicolau C Torra R Bianchi L | 2000 | J Clin Ultrasound2000，28，6： | 2 |
| 5 | The weighted OWA operator 显示文摘 | Torra V | 1997 | International of Intelligent Systems1997，12，2： | 1 |
| 6 | Ordinal, continuous and heterogeneous k-anonymitythrough microaggreagtion 显示文摘 | DOMING-FERRER J TORRA V | 2005 | Journal of Data Mining and Knowledge Discovery2005，11，2： | 1 |
| 7 | Income,inequality and poilu- tion:a reassessment of the environmental Kuznets curve 显示文摘 | TORRAS M BOYCE J K | 1998 | Ecological Economics1998，25，： | 1 |
| 8 | Income,inequality,and pollution:a reassessment of the environmental Kuznets curve 显示文摘 | TORRAS M BOYCE J K | 1998 | Ecological Economics1998，25，2： | 1 |
| 9 | High-temperature dilute-acid hydrolysis of olive stones for furfural production显示文摘 | Montane D Salvado J Torras C | 2002 | Biomass and Bioenergy2002，22，： | 1 |
| 10 | Hesitant fuzzy sets显示文摘 | Torra V | 2010 | International Journal of Intel- ligent Systems2010，25，： | 1 |
| 11 | The Weighted OWA Operator 显示文摘 | Torra V | 1997 | International Journal of Intelligent Systems1997，12，： | 1 |
| 12 | A loss of function model for cystogenesis in human autosomal dominant polycystic kidney disease type2显示文摘 | Torra R Badenas C San Millan JL | 1999 | Am J Hum Genet1999，65，： | 1 |
| 13 | Regression of advanced diabetie nephropathy by hepatocyte growth factor gene therapy in rats显示文摘 | Cruzado J M LIoberas N Torras J | 2004 | Diabetes2004，53，： | 1 |
| 14 | 3D collision detection:a survey显示文摘 | Jime Hnez P Thomas F Torras C | 2001 | Computers & Graphics2001，25，： | 1 |
| 15 | C:3D collision detection:a survey显示文摘 | Jimenez P Thomas F Torras | 2001 | Computers&Graphics2001，25，2： | 1 |
| 16 | Surgical Resection of Colorectal Liver Metastases in Patients with Expanded Indications: A Single-Center Experience with 501 Patients显示文摘 | Juan Figueras M.D. Jaume Torras M.D. Carlos Valls M.D. Laura Llado M.D. Emilio Ramos M.D. Joan Marti-Ragué M.D. Teresa Serrano M.D. Juan Fabregat M.D | 2007 | Diseases of the Colon & Rectum2007，，4： | 1 |
| 17 | Income, Inequality, and Pollution: A Reassessment of the Environmental Kuznets Curve 显示文摘 | Torras M Boyce J | 1998 | Ecological Economics1998，，25： | 1 |
| 18 | 3D collision detection: a survey 显示文摘 | Jimenez P Thomas F Torras C | 2001 | Computers & Graphics2001，25，2： | 1 |
| 19 | Ordinal,continuous and heterogeneous kanonymity through microaggregation显示文摘 | DOMINGO F J TORRA V | | 0，，02： | 1 |
| 20 | Liver transplantation across Rh blood group barriers Increases the risk of biliary complications显示文摘 | Busquets J Castellote J Torras J | | 0，，04： | 1 |
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